Search results for "LR"
showing 10 items of 764 documents
Implicación de los receptores TLR4 en el daño cerebral causado por el consumo de alcohol
2012
El abuso de alcohol puede causar daño cerebral y en ciertos casos cursa con neurodegeneración, aunque los mecanismos moleculares de estos efectos se desconocen. El Sistema Nervioso Central (SNC) ha sido considerado, hasta muy recientemente, como un sistema inmunológicamente privilegiado (Galea et al., 2007). Sin embargo, estudios de los últimos años indican que el cerebro coordina y regula numerosos aspectos de la respuesta inmune innata, y que la inflamación representa un factor crítico y esencial para muchas enfermedades del SNC, como son las enfermedades neurodegenerativas (Wild et al., 2008). Igualmente, la respuesta del sistema inmune innato también desempeña un papel crucial en el dañ…
Polises cenas aprēķināšanas lietotnes optimizācija
2019
Šajā dokumentā ir aprakstīts kvalifikācijas darbs “Polises cenas aprēķināšanas lietotnes optimizācija”, kas iekļauj sevī tādus dokumentus kā programmatūras prasību specifikācija, programmatūras projektējuma apraksts un testēšanas dokumentācija. Darba ietvaros ti ka veikta polišu cenas aprēķināšanas lietotnes optimizācija tiešsaites apdrošināšanas platformai Bamboo. Šīs optimizācijas mērķis ir pāatrināt apdrošināšanas polišu cenas aprēķināšanas lietotnē notiekošos procesus. Lai sasniegtu mērķi, tika identificēti iespējamie lietotnes uzlabojumi, izstrādāts jauns kalkulācijas modelis un formulu parsētājs.
Lielvaru (ASV un Ķīnas) sāncensība 21. gadsimtā
2022
Maģistra darba “Lielvaru (ASV un Ķīnas) sāncensība 21. gadsimtā” mērķis ir vairāku lielvaru augšupejas un lejupslīdes teoriju aplūkošana un analīze, saistot tās ar empīriskajiem novērojumiem par šādu sāncensību. Maģistra darbā apskatītās teorijas tiks pretnostatītas ASV un Ķīnas kā lielvaru sāncensībai mūsdienās, tādējādi veicinot izpratni par iespējamo šādas sāncensības izcelsmi un norisi, izrietot no vēsturiskiem gadījumiem, kas saistīti ar lielvaru sāncensību. Darba teorētiskā bāze ietver izklāstu par lielvaru raksturojumu un vairāku citu jēdzienu apskatīšanu, kā arī apskata četras lielvaru sāncensības teorijas. Maģistra darba empīrisko daļu veido lielvaru sāncensības vēsturiskā ietvara …
Ultrasonography (US) in the assessment of pediatric non traumatic gastrointestinal emergencies
2013
AbstractBackgroundNon traumatic gastrointestinal emergencies in the children and neonatal patient is a dilemma for the radiologist in the emergencies room and they presenting characteristics ultrasound features on the longitudinal and axial axis. The most frequent emergencies are : appendicitis, intussusceptions, hypertrophic pyloric stenosis, volvulus due to intestinal malrotation. The aim of this article is to familiarize the reader with the US features.MethodsA retrospective analysis of 200 ultrasound examinations performed in neonatal and children patients with fever, abdominal pain, leukocytosis, vomiting and diarrhea were evaluated.ResultsOf 200 exame 50 cases of intussusceptions, 100…
Acute appendicitis and situs viscerum inversus: radiological and surgical approach—a systematic review
2023
Abstract Introduction Acute appendicitis is one of the most frequent intra-abdominal diseases requiring emergency surgical consult and treatment. The diagnosis of this condition is based on clinical features and radiologic findings. One-third of patients with acute appendicitis present unusual symptoms. There are several circumstances that may cause misdiagnosis and unclear prognostic prediction. Among these, situs viscerum inversus totalis and midgut malrotation can be challenging scenarios, leading to a delay in treatment, especially when these conditions are unknown. We decided to carry on a systematic review of published cases of acute appendicitis in the context of anatomical anomalies…
Lo stadio di Wimbledon: per una teoria dell'adattamento
2013
Se "Lo stadio di Wimbledon" (1983) di Daniele Del Giudice nasce soprattutto come meditazione sulla vocazione creativa, sono certamente le suggestioni sulla scrittura a imporlo all’attenzione della critica. Del Giudice, che ha ribadito più volte nella sua opera la centralità dell’immaginario cinematografico, non ha certamente mai creduto alla presunta “inadattabilità” del suo romanzo: l’incontro con l’attore e regista francese Mathieu Amalric, che ha portato alla realizzazione del film "Le stade de Wimbledon" (2001), è stata un’occasione propizia per ulteriori riflessioni sull’adattamento. Ma è tornando alla pagina scritta che si trova l’intuizione più importante, ben nascosta nella trama de…
Neuroimmune Activation and Myelin Changes in Adolescent Rats Exposed to High-Dose Alcohol and Associated Cognitive Dysfunction: A Review with Referen…
2014
Aims: The aim of the study was to assess whether intermittent ethanol administration to adolescent rats activates innate immune response and TLRs signalling causing myelin disruption and long-term cognitive and behavioural deficits. Methods: We used a rat model of intermittent binge-like ethanol exposure during adolescence. Results: Binge-like ethanol administration to adolescent rats increased the gene expression of TLR4 and TLR2 in the prefrontal cortex (PFC), as well as inflammatory cytokines TNF alpha and IL-1 beta. Up-regulation of TLRs and inflammatory mediators were linked with alterations in the levels of several myelin proteins in the PFC of adolescent rats. These events were assoc…
TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.
2008
ABSTRACT Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that mig…
LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: Biological effects of +896A/G TLR4 polymorphism in…
2011
Toll-like receptors (TLRs) are the principal mediators of rapid microbial recognition: the lipopolysaccharide (LPS) receptor TLR4 seems to have a paradigmatic role. Single nucleotide polymorphisms (SNPs) in the TLR4 gene, such as +896A/G, known to attenuate receptor signaling, have been described. The +896A/G SNP is significantly less frequent in patients with myocardial infarction, Alzheimer's disease or prostate cancer, whereas it is overrepresented in centenarians. To clarify and confirm the biological effects of +896A/G SNP and its role in the pathophysiology of age-related diseases and longevity, we assessed the levels of IL-6, TNF-α, IL-10 and eicosanoids (LTB4 and PGE2) in LPS-stimul…
Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful aging.
2007
The total burden of infection at various sites may affect the progression of atherosclerosis and Alzheimer's disease (AD), the risk being modulated by host genotype. The role of lipopolysaccharide (LPS) receptor TLR4 is paradigmatic. It initiates the innate immune response against gram-negative bacteria, and TLR4 single nucleotide polymorphisms (SNPs), such as +896A/G, known to attenuate receptor signaling, have been described. This SNP shows a significantly lower frequency in patients affected by myocardial infarction or AD. Thus, people genetically predisposed to developing lower inflammatory activity seem to have less chance of developing cardiovascular disease (CVD) or AD. In the presen…