Search results for "LR"

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

2011

Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleot…

2015

Summary A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monocytes (MO), and hyperglycaemia may be able to modulate, in the cytoplasm of these cells, the assembly of a nucleotide-binding domain and leucine-rich repeat containing family pyrin (NLRP3)-inflammosome, a cytosolic multi-protein platform where the inactive pro-IL-1β is cleaved into active form, via caspase-1 activity. In this paper, we evaluated the production of IL-1 β …

Numerical study for a new methodology of flaws detection in train axles

2013

Train loads and travel speeds have increased over time, requiring more efficient non-destructive inspection methods. Railway axles are critical elements; despite being designed to last more than 20 years several cases of premature failure have been recorded. Train axles are inspected regularly, but the limits associated to the traditional inspection technologies create a growing interest towards new solutions. Here a novel non-destructive inspection method of in-service axles based on non-contact data collection is presented. The propagation of surface waves, generated by a thermo-elastic laser source, is investigated using a finite element method based on dynamic explicit integration. Coup…

Réalisation de la rente et généralisation du surplus dans le système de Walras

1986

Pour David Ricardo la rente est un effet de prix, en ce sens que sur la terre non marginale, le prix du marché des produits agricoles est plus élevé que le coût de production. Il précise en outre que le prix courant varie en fonction de l’offre et de la demande. (Principes p. 89 - Ed. Calmann Lévy.). Aussi la raison de l’apparition et de l’augmentation de la rente est-elle l’accroissement de la demande des produits agricoles. En effet, l’augmentation de la demande est la cause de la mise en culture des terres de moins en moins fertiles. Moyennant l’emploi d’un même capital, sur des terres de fertilités différentes, le produit net est nul pour la terre marginale alors qu’il est positif pour …

CLINICAL OUTCOMES OF SELF-EXPAMDABLE METALLIC STENTS IN PALLIATION OF MALIGNANT ANASTOMOTIC STRICTURES: A SINGLE CENTER EXPERIENCE

2015

Background: self-expandable metallic stents (SEMS) are employed as the preferred non surgical palliative treatment for gastric outlet obstruction due to malignancies. Metallic stents are often employed to treat malignant anastomotic obstructions after surgicsl interventions as esophagojejunostomy, gastrojejunostomy and esophagogastrojejunostomy. Methods: this case series reports prospectively the clinical outcomes of SEMS in the palliative care of malignant anastomotic strictures caused by the recurrence gastric cancer follwing gastric surgery as oncological curative treatment, in a series of nine consecutive patients, treated between January 2009 and december 2012 in our center. Results: N…

Diferencialrēķini un integrālrēķini: inženierzinātņu un mehānikas fakultātes studentiem

1941

Integrālie rēķini

1941

Saturs: 1. d. Nenoteiktie integrāli -- 2. d. Noteiktie integrāļi -- Pielikums: Zīmējumi

CpG-DNA loaded multifunctional MnO nanoshuttles for TLR9-specific cellular cargo delivery, selective immune-activation and MRI

2012

Initiation of pathways that lead to a proliferation and chemoresistance by Toll-like receptors (TLRs) are an important factor in cancer progression. Multifunctional magnetic nanoparticles equipped with a pathogen-derived ligand (CpG) functioning as TLR agonists were used to show the impact of immune activation on human HNSCC (head and neck squamous cell carcinoma) cells. The response of human cancer cells to TLR signaling is linked to tumor biology. The magnetic MnO nanoparticles were coated with a multifunctional polymer, displaying no cytotoxicity and being able to enter cells while carrying foreign DNA (unmethylated CpG) to recognize intracellular TLR9. Both the particle and the nucleic …

Equivalences between refractive index and equilibrium water content of conventional and silicone hydrogel soft contact lenses from automated and manu…

2007

PURPOSE: The purpose of the present study was to develop mathematical relationships that allow obtaining equilibrium water content and refractive index of conventional and silicone hydrogel soft contact lenses from refractive index measures obtained with automated refractometry or equilibrium water content measures derived from manual refractometry, respectively. METHODS: Twelve HEMA-based hydrogels of different hydration and four siloxane-based polymers were assayed. A manual refractometer and a digital refractometer were used. Polynomial models obtained from the sucrose curves of equilibrium water content against refractive index and vice-versa were used either considering the whole range…

Isometries of nilpotent metric groups

2016

We consider Lie groups equipped with arbitrary distances. We only assume that the distance is left-invariant and induces the manifold topology. For brevity, we call such object metric Lie groups. Apart from Riemannian Lie groups, distinguished examples are sub-Riemannian Lie groups and, in particular, Carnot groups equipped with Carnot-Carath\'eodory distances. We study the regularity of isometries, i.e., distance-preserving homeomorphisms. Our first result is the analyticity of such maps between metric Lie groups. The second result is that if two metric Lie groups are connected and nilpotent then every isometry between the groups is the composition of a left translation and an isomorphism.…