Search results for "LR"

Proton Transfer and Protein Conformation Dynamics in Photosensitive Proteins by Time-resolved Step-scan Fourier-transform Infrared Spectroscopy

2014

Monitoring the dynamics of protonation and protein backbone conformation changes during the function of a protein is an essential step towards understanding its mechanism. Protonation and conformational changes affect the vibration pattern of amino acid side chains and of the peptide bond, respectively, both of which can be probed by infrared (IR) difference spectroscopy. For proteins whose function can be repetitively and reproducibly triggered by light, it is possible to obtain infrared difference spectra with (sub)microsecond resolution over a broad spectral range using the step-scan Fourier transform infrared technique. With -10(2)-10(3) repetitions of the photoreaction, the minimum num…

Tumor-Derived Small Extracellular Vesicles Induce Pro-Inflammatory Cytokine Expression and PD-L1 Regulation in M0 Macrophages via IL-6/STAT3 and TLR4…

2021

Tumor-associated macrophages play a key role in promoting tumor progression by exerting an immunosuppressive phenotype associated with the expression of programmed cell death ligand 1 (PD-L1). It is well known that tumor-derived small extracellular vesicles (SEVs) affect the tumor microenvironment, influencing TAM behavior. The present study aimed to examine the effect of SEVs derived from colon cancer and multiple myeloma cells on macrophage functions. Non-polarized macrophages (M0) differentiated from THP-1 cells were co-cultured with SEVs derived from a colorectal cancer (CRC) cell line, SW480, and a multiple myeloma (MM) cell line, MM1.S. The expression of PD-L1, interleukin-6 (IL-6), a…

Construction and Implementation of LR(1) Parsers

1990

This chapter is devoted to the practical issues involved in the construction and use of deterministic LR(1) parsers. We shall show how the practical versions of LR (1) parsers, most notably the LALR (1) parsers, can be constructed efficiently, and we shall present methods for encoding LR(1) parsers as efficient RAM programs. Two versions of RAM program implementation are considered: in the first implementation the parsing program is table-driven, that is, the rules of the parser are encoded in a two-dimensional array which is simulated by a program body; in the other implementation the tabular information is further transformed into a set of program statements.

Species and habitat biodiversity measure and conservation at different scale in small Mediterranean islands

2017

Small islands are geographically and ecologically well-defined areas in which biological processes are easier to schematize than in the mainland. There is a vast range of biodiversity measures, due to the large concept of biodiversity and the range of spatial, temporal and taxonomic scales used. Many existing measures are well designed and informative. But, very often they are inadequate for purposes beyond those for which they were specifically designed. Knowledge on trends in biodiversity loss is hindered by the absence of reliable basic data for most groups of organisms as well as habitats. Plants are primary producers and key structural elements for most ecosystems and islands are among…

Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation

2022

Experimental constraints on pre-eruptive conditions of a chemically-zoned peralkaline ignimbrite: the Green Tuff eruption at Pantelleria Island (Ital…

2015

Pantelleria island is the type locality for pantellerite, an iron and alkali-rich rhyolite. The eruptive products outcropping in the island fall in a mafic end member (mildly alkaline basalt) and a felsic end member (metaluminous trachytes and pantellerites). A key event in the volcanological history of the island is the Green Tuff eruption the sole ignimbrite at Pantelleria compositionally zoned from crystal-poor pantellerite at the base to crystal-rich trachyte at the top. We experimentally investigated the phase relations of the pantelleritic end member AI = 1.8 (agpaitic index = molar ratio Na2O+K2O/Al2O3) and trachyte end member AI = 1.05 of the Green Tuff eruption. The intensive varia…

A proposal for improving the elastic behaviour of dogbone

2022

The Reduced Beam Section (RBS) connections are one of the prequalified connections approved by international standards and adopted to improve the seismic behaviour of steel Moment Resisting Frames (MRF) also protecting the joint between beams and columns. This goal is reached by locally reducing the resistance of a selected portion of the beam element by suitably trimming the flanges, to promote in that portion the onset of plastic deformations. In the framework of RBS, the most important typology proposed is the so-called dogbone (DB) connections that are widely diffused in seismic engineering. The essential advantages of DB are related to the protection of the welded cross section between…

The simbolic indication of heraldry as an approach to enrich souvenir(metal Brooch)

2010

The research is based on the benefit ffrom the study of the symbolic indication of heraldry trought well Known civilization on the Mediterranea Sea; the importance of the research comes from its offeringof the study of an important part for the aim of development of innovated design for souvenir metal brooch with the aim of the awareness of the young of the importance of the artistic heritage which may link periods of times and nations together and arguing the young on necessity of keeping it.

L'Alta Velocità in Cina. Politiche, strategie, territori

2014

High Speed railways in China. Policies, strategies and territories. by Marc Guigon The history of High-Speed railways in China is not a linear one, traced in the course of a rigorous planning process. It has on the contrary experienced moments of rapid surge, only to be followed by periods of slower growth. Fervid action, decision-making and euphoria have been accompanied by scathing failures, against a background of corruption and complex relations with the foreign providers of fundamental technology. The ! nal result is noteworthy however, because China currently has the largest High-Speed railroad network in the world, with a very high level of customer satisfaction, though the cost has …

L'infrastruttura scomparsa. Il nuovo suolo della stazione Sagrera Alta Velocità a Barcellona

2014

The vanishing infrastructure. The new ground of the Sagrera High-Speed railway station in Barcelona The current railway station mega-project in Barcelona Sagrera highlights the link between the construction of the new High- Speed station and a vast linear park that will cover the existing railroad tracks. In the framework of one of the largest and most ambitious railway and urban redevelopment projects currently underway in all of Europe, this article focuses on the subordination of the Station to the park, which apart from being a mere issue of location (the station is literally under the park), can be reframed within a theoretical debate on the role of architecture in these truly signific…