Search results for "LRI"
showing 10 items of 81 documents
Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium
1999
This study was aimed at evaluating the in vitro effects of phosphodiesterase inhibitors and beta2-adrenoceptor agonists on spontaneous contractions of human term myometrium. Rolipram, RP 73401 (3-cyclopentyloxy-N-(3,5(-dichloro-4-pyridil)-4-methoxybenzamide) and Ro 20-1724 (1-4-(3-butoxy-4-methoxybenzyl)-2-imidozolidinone) (phosphodiesterase 4 inhibitors) inhibited spontaneous myometrial contractions (Emax approximately 100%; pD2 of 6.80+/-0.28, 6.84+/-0.32 and 6.31+/-0.03, respectively). Salbutamol and formoterol were less effective (Emax=40+/-6% and 35+/-12%, respectively) than phosphodiesterase 4 inhibitors to reduce myometrial contractility. Inhibitors of phosphodiesterase 3 (milrinone …
Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regula…
2015
Background Collagen VI related myopathies encompass a range of phenotypes with involvement of skeletal muscle, skin and other connective tissues. They represent a severe and relatively common form of congenital disease for which there is no treatment. Collagen VI in skeletal muscle and skin is produced by fibroblasts. Aims & Methods In order to gain insight into the consequences of collagen VI mutations and identify key disease pathways we performed global gene expression analysis of dermal fibroblasts from patients with Ullrich Congenital Muscular Dystrophy with and without vitamin C treatment. The expression data were integrated using a range of systems biology tools. Results were validat…
Joseph Conrad-Korzeniowski, an English Writer with a Polish Soul: Joseph Conrad’s Polish Heritage
2018
The article presents a portrait of Joseph Conrad-Korzeniowski, an English writer with a Polish soul. Conrad—the last Polish Romantic—did not only manage to introduce Polish dreams and longings into English (and Western) literature, but also transformed the Polish experience into a universal one. Writing about exotic, faraway places, he disseminated myths concerning Polish national identity, chivalric tradition and the Polish Eastern Borderland atmosphere and ethos. Conrad, a very demanding writer, never presents ready-made answers, nor does he offer simple solutions to the problems of his protagonists. Moreover, everybody can understand Conrad in their own personal way, for he is perceived …
Ulrich bundles on K3 surfaces
2019
We show that any polarized K3 surface supports special Ulrich bundles of rank 2.
Alma Mater: 2014/ Vasara
2014
Andra Čudare. Studentu taisnības bruņinieks Kirils Solovjovs -- Katrīna Žukova. Zinību lauks – atmiņu laiks -- LU māju noslēpumi atklājās Muzeju naktī -- LU Preses centrs. Zinātne – tas ir forši un radoši -- Sarmīte Rutkovska. Futbols kā tikšanās vieta -- LU Zinātnes un tehnikas vēstures muzejs, LU Preses centrs. Fotostāsts. Studentu mode cauri laikiem -- Laine Dobulāne. Atjauno modernākās ērģeles Latvijā -- LU Preses centrs. Praktiķi dalās pieredzē ar topošajiem kolēģiem -- LU Preses centrs. Reportāža. Psihiskas performances un «Ātrā palīdzība» jauno grupu konkursā «Hadrons» -- LU Bibliotēka. Ciparojot šodienai un nākotnei: LU Bibliotēkas pieredze digitalizācijā -- Kārlis Dārznieks. Jau 85…
Species and habitat biodiversity measure and conservation at different scale in small Mediterranean islands
2017
Small islands are geographically and ecologically well-defined areas in which biological processes are easier to schematize than in the mainland. There is a vast range of biodiversity measures, due to the large concept of biodiversity and the range of spatial, temporal and taxonomic scales used. Many existing measures are well designed and informative. But, very often they are inadequate for purposes beyond those for which they were specifically designed. Knowledge on trends in biodiversity loss is hindered by the absence of reliable basic data for most groups of organisms as well as habitats. Plants are primary producers and key structural elements for most ecosystems and islands are among…
Experimental constraints on pre-eruptive conditions of a chemically-zoned peralkaline ignimbrite: the Green Tuff eruption at Pantelleria Island (Ital…
2015
Pantelleria island is the type locality for pantellerite, an iron and alkali-rich rhyolite. The eruptive products outcropping in the island fall in a mafic end member (mildly alkaline basalt) and a felsic end member (metaluminous trachytes and pantellerites). A key event in the volcanological history of the island is the Green Tuff eruption the sole ignimbrite at Pantelleria compositionally zoned from crystal-poor pantellerite at the base to crystal-rich trachyte at the top. We experimentally investigated the phase relations of the pantelleritic end member AI = 1.8 (agpaitic index = molar ratio Na2O+K2O/Al2O3) and trachyte end member AI = 1.05 of the Green Tuff eruption. The intensive varia…
"Par un ennemi qu'on sait digne de soi": la lunga traccia delle coppie antinomiche
2021
The contribution deals with antinomic couples, actual rivalries, symbolic confrontations; it is part of a discussion among scholars about the subject, in a column edited by the author and Niccolò Scaffai
La tradition italienne du roman de chevalerie dans le miroir du "Don Quichotte"
2019
Résumé La tradition italienne du roman de chevalerie et le Don Quichotte ont été mis en relation principalement de deux manières. En premier lieu, la critique moderne a souvent rapproché le Quichotte du Roland furieux de l?Arioste en raison d?un dialogue à la fois textuel et structurel d?une grande complexité, s?étalant sur plusieurs niveaux de composition ; en outre, la réception et la canonisation des deux chefs-d??uvre, successifs mais idéalement conjoints, ont été liées à la dissolution de l?idéal chevaleresque, à la fondation du roman moderne, et même à la naissance de l?idée moderne de l?Homme. En deuxième lieu, le Quichotte représente une sorte de « stade du miroir » du genre après C…
Surfaces of minimal degree of tame representation type and mutations of Cohen–Macaulay modules
2017
We provide two examples of smooth projective surfaces of tame CM type, by showing that any parameter space of isomorphism classes of indecomposable ACM bundles with fixed rank and determinant on a rational quartic scroll in projective 5-space is either a single point or a projective line. For surfaces of minimal degree and wild CM type, we classify rigid Ulrich bundles as Fibonacci extensions. For the rational normal scrolls S(2,3) and S(3,3), a complete classification of rigid ACM bundles is given in terms of the action of the braid group in three strands.