Search results for "LTER"

showing 10 items of 3539 documents

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

2019

Abstract Background Cucurbitacin E (CuE) is an oxygenated tetracyclic triterpenoid isolated from the fruits of Citrullus colocynthis (L.) Schrad. Purpose This study outlines CuE's cytotoxic activity against drug-resistant tumor cell lines. Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated, whose overexpression in tumors is tightly linked to multidrug resistance. Further factors of drug resistance studied were the tumor suppressor TP53 and the epidermal growth factor receptor (EGFR). Methods Cytotoxicity assays (resazurin assays) were used to investigate the activity of Citrullus colocynthis and CuE towar…

Abcg2Drug ResistancePharmaceutical ScienceATP-binding cassette transporterMicroarraySubfamily Gchemistry.chemical_compoundGene Knockout Techniques0302 clinical medicineEpidermal growth factorPhytogenicDrug DiscoveryATP Binding Cassette Transporter Subfamily G Member 2Cancer0303 health sciencesTumorLeukemiabiologyChemistryABCB5TransfectionCell cycleNeoplasm ProteinsGene Expression Regulation NeoplasticErbB ReceptorsMolecular Docking SimulationSubfamily B030220 oncology & carcinogenesisMolecular MedicineCitrullus colocynthiMember 2Member 1ATP Binding Cassette Transporter Subfamily BATP Binding Cassette TransporterAntineoplastic AgentsCell Line03 medical and health sciencesCell Line TumorHumansATP Binding Cassette Transporter Subfamily B Member 1030304 developmental biologyCucurbitacin EPharmacologyNeoplasticTraditional herbal medicineCancer; Citrullus colocynthis; Drug resistance; Microarray; Traditional herbal medicine; ATP Binding Cassette Transporter Subfamily B; ATP Binding Cassette Transporter Subfamily B Member 1; ATP Binding Cassette Transporter Subfamily G Member 2; Antineoplastic Agents Phytogenic; Cell Line Tumor; Citrullus colocynthis; Doxorubicin; Drug Resistance Neoplasm; ErbB Receptors; Gene Expression Regulation Neoplastic; Gene Knockout Techniques; Humans; Leukemia; Molecular Docking Simulation; Neoplasm Proteins; Triterpenes; Tumor Suppressor Protein p53Antineoplastic Agents PhytogenicTriterpenesComplementary and alternative medicineGene Expression RegulationDrug Resistance NeoplasmDoxorubicinCancer cellbiology.proteinCancer researchNeoplasmCitrullus colocynthisTumor Suppressor Protein p53
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Impact of monitoring on detection of arrhythmia recurrences in the ESC-EHRA EORP atrial fibrillation ablation long-term registry

2019

Abstract Aims Monitoring of patients after ablation had wide variations in the ESC-EHRA atrial fibrillation ablation long-term (AFA-LT) registry. We aimed to compare four different monitoring strategies after catheter AF ablation. Methods and results The ESC-EHRA AFA-LT registry included 3593 patients who underwent ablation. Arrhythmia monitoring during follow-up was performed by 12-lead electrocardiogram (ECG), Holter ECG, trans-telephonic ECG monitoring (TTMON), or an implanted cardiac monitoring (ICM) system. Patients were selected to a given monitoring group according to the most extensive ECG tool used in each of them. Comparison of the probability of freedom from recurrences was perfo…

Ablation Techniquesmedicine.medical_specialtymedicine.medical_treatmentAftercareKaplan-Meier EstimateElectrocardiographyRecurrencePhysiology (medical)Internal medicineAtrial FibrillationmedicineHumansTelemetryRegistriescardiovascular diseasesMonitoring methodsbusiness.industryCardiac arrhythmiaAtrial fibrillationmedicine.diseaseAblationTelephoneEcg monitoringCatheterElectrocardiography AmbulatoryCardiologyCardiac monitoringCardiology and Cardiovascular MedicinebusinessHolter ecgEP Europace
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Post-mortem alteration of diet-related enamel surface textures through artificial biostratinomy: A tumbling experiment using mammal teeth

2019

In the fossil record, teeth are often all that remains of a fossil organism. Dental microwear texture analysis (DMTA) is a common proxy for diet using dental wear features at the μm-scale, enabling comparative and quantitative assessments of various feeding traits in extant and extinct species. In extinct species, original diet-related dental wear features may be overprinted by post-mortem alteration including fluvial transport. Here we experimentally investigate the effects of mechanical alteration on diet-related 3D enamel surface texture (3DST) patterns of different mammal teeth. Post canine teeth of Equus sp., Capreolus capreolus and Otomys sp. are tumbled in sediment-water suspensio…

Abrasion (dental)010506 paleontologyMammal teethDental wearMineralogy010502 geochemistry & geophysicsOceanography01 natural sciencesBiostratinomyBiostratinomyCapreolusstomatognathic systemSurface roughnessmedicineSurface textureEcology Evolution Behavior and Systematics0105 earth and related environmental sciencesEarth-Surface ProcessesDiagenetic alterationbiologyEnamel paintPaleontology15. Life on landbiology.organism_classificationmedicine.diseaseEquusGrain sizeOtomysMicrowearvisual_artvisual_art.visual_art_mediumGeology
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Training Programs – Training and Development Alternatives for Students

2013

Abstract Training programs have been established as a form of training for adults, being generally used within companies’ personal development alternatives starting from the employees’ performance assessment processes. The current century requires a different way of approaching academic education, starting from the employers’ observation in reference to the lack of the graduates’ key competencies in the hiring process. We intend to demonstrate that it is useful to introduce training programs as an alternative form of education in academia, as well as in the high school environment.

Academic educationMedical educationtrainingProcess (engineering)business.industrydesignGeneral Engineeringalternatives.Energy Engineering and Power TechnologyTraining and developmentTraining (civil)teamManagementPersonal developmentcompetencesSchool environmentPsychologybusinessProcedia Economics and Finance
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Vertical Beam Polarization at MAMI

2017

For the first time a vertically polarized electron beam has been used for physics experiments at MAMI in the energy range between 180 and 855 MeV. The beam-normal single-spin asymmetry $A_{\mathrm{n}}$, which is a direct probe of higher-order photon exchange beyond the first Born approximation, has been measured in the reaction $^{12}\mathrm C(\vec e,e')^{12}\mathrm C$. Vertical polarization orientation was necessary to measure this asymmetry with the existing experimental setup. In this paper we describe the procedure to orient the electron polarization vector vertically, and the concept of determining both its magnitude and orientation with the available setup. A sophisticated method has …

Accelerator Physics (physics.acc-ph)Nuclear and High Energy PhysicsPhysics - Instrumentation and DetectorsPhotonmedia_common.quotation_subjectVertical polarization[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]FOS: Physical sciencesElectron acceleratorElectronMott polarimeter01 natural sciencesAsymmetrylaw.inventionOpticsMøller polarimeterlaw0103 physical sciencesCompton polarimeter[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det][ PHYS.PHYS.PHYS-ACC-PH ] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]Born approximation010306 general physicsNuclear Experiment[ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]Instrumentationmedia_commonPhysicsWien filter010308 nuclear & particles physicsbusiness.industryParticle acceleratorPolarimeterInstrumentation and Detectors (physics.ins-det)Wien filterPolarization (waves)Electron accelerator ; Vertical polarization ; Wien filter ; Compton polarimeter ; Mott polarimeter ; Møller polarimeterPhysics - Accelerator Physicsbusiness
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Residual errors in ASTER temperature and emissivity standard products AST08 and AST05

2011

Abstract Land surface temperature and emissivity are independent variables, and the thermal-infrared spectral radiance measured in remote sensing is dependent on both. Therefore the inverse Planck equation is under-determined, with two unknowns and a single measurement. Practical inversion algorithms designed to calculate temperature and emissivity from the measurements cannot do a perfect job of separation, and recovered temperature and emissivity may co-vary. For ASTER images, validation studies of recovered temperature and emissivity, regarded individually, have shown that they are within the precision and accuracy limits predicted in designing the ASTER TES algorithm used to calculate …

Accuracy and precisionPlanck's lawSpatial filterRadianceEmissivitySoil ScienceEnvironmental scienceGeologyComputers in Earth SciencesResidualAtmospheric temperatureScalingRemote sensingRemote Sensing of Environment
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Agrobacterium tumefaciens-mediated genetic transformation of the cardenolide-producing plant Digitalis minor L.

2003

A repeatable transformation system has been established for Digitalis minor using Agrobacterium tumefaciens. Leaf explants from 30-day-old seedlings were inoculated with either EHA105 (carrying the nptII and gusA genes) or AGL1 (with the bar and gusA genes) strains. Among the tested factors influencing T-DNA transfer to plants, the EHA105 strain and the addition of acetosyringone to the co-culture medium increased transformation. The highest transformation efficiency (8.4%) was obtained when freshly isolated explants, soaked in a bacterial suspension with an OD 550 of 0.9, were subcultured on selection medium after a 4-day co-culture with the bacteria. Evidence of stable transgene integrati…

AcetosyringoneAgrobacteriumPharmaceutical ScienceGenetically modified cropsBiologyAnalytical Chemistrychemistry.chemical_compoundTransformation GeneticDrug DiscoveryBotanyCardenolideHumansPharmacologyDigitalisfungiOrganic Chemistryfood and beveragesAgrobacterium tumefaciensbiology.organism_classificationPlants Genetically ModifiedPlant LeavesTransformation (genetics)Complementary and alternative medicinechemistryAgrobacterium tumefaciensMolecular MedicineTransformation efficiencyExplant culturePlanta medica
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Q-switching of an all-fiber ring laser based on in-fiber acousto-optic bandpass modulator2017

2017

Active Q-switching of an all-fiber ring laser utilizing a novel in-fiber acousto-optic tunable bandpass filter (AOTBF) is reported. The transmission characteristics of the AOTBF are controlled by amplitude modulation of the acoustic wave; the device exhibits a 3-dB power insertion loss, 0.91-nm optical bandwidth, and 28-dB nonresonant light suppression. Cavity loss modulation is achieved by full acousto-optic mode re-coupling cycle induced by traveling flexural acoustic waves. When the acoustical signal is switched on, cavity losses are reduced, and then, laser emission is generated. In addition, by varying the acoustic wave frequency, a wide wavelength tuning range of 30.7 nm is achieved f…

Acousto-optic modulationAcousto-optic filters:FÍSICA::Óptica ::Fibras ópticas [UNESCO]Fiber opticsBandpass filtersUNESCO::FÍSICA::Óptica ::Fibras ópticasFiber Lasers
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A New Adaptive Neural Harmonic Compensator for Inverter Fed Distributed Generation

2004

This paper deals with the command of inverters in DG (distributed generation) systems by use of linear neural networks in such a way that, with a slight upgrade of their control software, they can be used also to compensate for the harmonic distortion in the node where they are connected (local compensation), that is in the in the point of common coupling (PCC). To this purpose a neural estimator based on linear neurons (ADALINEs) has been developed which is able to act as a selective noise cancellers for each harmonic of the node voltage. The use of linear neurons permits the drawbacks of classical neural networks to be overcome and moreover the neural estimator is easy to implement, thus …

Active filtersseries activePower qualityharmonic compensationneural networks.Distributed generation
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Model Predictive Control for Shunt Active Filters With Fixed Switching Frequency

2016

This paper presents a modification to the classical Model Predictive Control algorithm, named Modulated Model Predictive Control, and its application to active power filters. The proposed control is able to retain all the advantages of a Finite Control Set Model Predictive Control whilst improving the generated waveforms harmonic spectrum. In fact a modulation algorithm, based on the cost function ratio for different output vectors, is inherently included in the MPC. The cost function-based modulator is introduced and its effectiveness on reducing the current ripple is demonstrated. The presented solution provides an effective and straightforward single loop controller, maintaining an excel…

Active filters; harmonic distortion; model predictive control (MPC); power filters; power quality; smart gridsEngineeringmodel predictive control (MPC)020209 energyRipple02 engineering and technologyIndustrial and Manufacturing EngineeringHarmonic analysisHarmonic spectrumControl theory0202 electrical engineering electronic engineering information engineeringElectronic engineeringsmart gridsWaveformElectrical and Electronic EngineeringActive filterModel Predictive ControlActive filtersTotal harmonic distortionbusiness.industry020208 electrical & electronic engineeringpower filtersAC powerpower qualityharmonic distortionModel predictive controlControl and Systems Engineeringbusiness
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