Search results for "LTR"
showing 10 items of 6853 documents
Il distacco e la separazione emotiva nel rapporto tra genitori e figli adolescenti
2012
Il viaggio di Louis Golding in Sicilia
2010
Nel contesto della scrittura odeporica che, tra fine Otoocento e primi del Novecento, ha come protagonistoa una delle più importanti, e al contempo, discusse isole del Mediterraneo, "Magdalen in Sicily", breve resoconto di viaggio di Luois Golding in Sicilia pubblicato nel 1925 su English review, si rivela sia 'object oriented' sia subject oriented'. Se da un lato affonda le proprie radici discorsive nelle scritture di viaggio di secondo Ottocento sulla frontiera imperiale, proponendo modellizazioni razziali tipiche di quei resoconti, dall'altro, il travelogue riprende una problematica cara all'Inghilterra di fine Ottocento, la degenerazione, ricontestaluizzandola in un periodo che segue la…
Photoinduced lethal and sublethal toxicity of retene, a polycyclic aromatic hydrocarbon derived from resin acid, to coregonid larvae
2004
A comparative investigation on the acute phototoxicity of retene to vendace (Coregonus albula) and whitefish (C. lavaretus), both having pelagial larvae in spring, was conducted. To test the concept of early warning of sublethal biomarkers in relation to lethality to posthatch stages, we examined the effects of ultraviolet-B (UV-B) and retene on the levels of cytochrome P4501A (CYP1A) and heat shock protein 70 (HSP70) by exposing the animals to elevated levels of these factors for 48 and 72 h, respectively. Whereas UV-B and retene on their own were not lethal, simultaneous retene and UV-B exposure caused very high mortality to both species. The median lethal concentration (LC50; i.e., the c…
Choroidal thickness in glaucoma patients and glaucoma suspects measured by spectral domain coherence optical tomography
2012
Purpose: The aim of our study was to evaluate and compare retro-foveolar choroidal thickness (RFCT) of healthy subjects, individuals with intraocular hypertension, patients with primary open-angle glaucoma (POAG), patients with normal tension glaucoma (NTG) and patients with primary angle-closure glaucoma (PACG) by spectral domain optical coherence tomography (SD-OCT).Methods: Sixty-five healthy eyes, 30 eyes with intraocular hypertension, 90 eyes with POAG, 30 eyes with NTG and 20 eyes with PACG were included in this cross-sectional study. RFCT, foveolar retinal thickness and average retinal nerve fiber layer thickness (RNFL) were measured by SD-OCT (Spectralis HRA-OCT, Heidelberg Engineer…
Targeting the mevalonate pathway for improved anticancer therapy.
2009
The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…
Inhibition of Protein Isoprenylation Impairs Rho-Regulated Early Cellular Response to Genotoxic Stress
2000
Activation of c-Jun N-terminal kinases (JNKs) and nuclear factor-kappaB (NF-kappaB) are early cellular responses to genotoxic stress involved in the regulation of gene expression. Pretreatment of cells with the hydroxymethyl glutaryl-CoA reductase inhibitor lovastatin blocked stimulation of JNK1 activity by UV irradiation and by treatment with the alkylating compound methyl methanesulfonate but did not affect activation of extracellular signal-regulated kinase 2 by UV light. Lovastatin also attenuated UV-induced degradation of the NF-kappaB inhibitor IkappaBalpha. The effects of lovastatin on UV-triggered stimulation of JNK1 as well as on IkappaBalpha degradation were reverted by cotreatmen…
Trattamento infiltrativo ecoguidato d'anca versus infiltrazioni associate a terapia riabilitativa: studio randomizzato controllato
2013
La coxartrosi è una malattia, caratterizzata da deterioramento della cartilagine e delle strutture articolari, che si manifesta clinicamente con dolore ingravescente e conseguente riduzione della funzionalità. Presso l'U.O.C. di Riabilitazione dell'A.O.U.P. Paolo Giaccone, tra febbraio 2008 e gennaio 2013 sono stati reclutati 224 soggetti sottoposti ad un ciclo infiltrativo che prevedeva 3 somministrazioni intrarticolari di acido ialuronico, eseguite sotto guida ecografica, a distanza di 45 giorni l'una dall'altra; i pazienti sono stati suddivisi, in modo random, in 2 gruppi (gruppo A e gruppo B). Il gruppo A è stato sottoposto solamente a trattamento infiltrativo; al gruppo B è stato assoc…
Trattamento riabilitativo interventistico ecoguidato nella fascite plantare
2013
Con il termine "fascite plantare" si intende un processo infiammatorio della aponeurosi o fascia plantare, strettamente correlato ai microtraumi che il piede sopporta durante la falcata. Nel periodo compreso tra giugno 2011 e gennaio 2013 sono stati reclutati presso l'U.O.C di Riabilitazione dell'A.O.U.P. Paolo Giaccone, 78 pazienti affetti da fascite plantare monolaterale e trattati con 3 infiltrazioni di metilprednisolone acetato e lidocaina in sede dolorosa sull'inserzione calcaneare della fascia sotto guida ecografica e prescrizione di un'ortesi plantare. I dati ottenuti dimostrano risultati soddisfacenti nella riduzione della sintomatologia algica nel breve, medio e lungo termine.