Search results for "LUDI"
showing 10 items of 753 documents
Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis.
2009
An important component of the pathogenic process of multiple sclerosis (MS) is the blood-brain barrier (BBB) damage. We recently set an in vitro model of BBB, based on a three-cell-type co-culture system, in which rat neurons and astrocytes synergistically induce brain capillary endothelial cells to form a monolayer with permeability properties resembling those of the physiological BBB. Herein we report that the serum from patients with secondary progressive multiple sclerosis (SPMS) has a damaging effect on isolated neurons. This finding suggests that neuronal damaging in MS could be a primary event and not only secondary to myelin damage, as generally assumed. SPMS serum affects the perme…
Discordance rate of HER2 status in primary breast carcinomas versus synchronous axillary lymph node metastases: a multicenter retrospective investiga…
2014
Antonio Ieni,1 Valeria Barresi,1 Rosario Caltabiano,2 Anna Maria Cascone,3 Rachele Del Sordo,4 Daniela Cabibi,5 Pio Zeppa,3 Salvatore Lanzafame,2 Angelo Sidoni,4 Vito Franco,5 Giovanni Tuccari1 1Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina, 2Department GF Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, 3Department of Medicine and Surgery, University of Salerno, Salerno, 4Institute of Pathologic Anatomy and Histology, Division of Cancer Research, University of Perugia, Perugia, 5Department of Human Pathology, Section of Anatomic Pathology, University of Palermo, Palermo, Italy Background: Human epiderma…
Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model
2015
Breakdown of the blood-brain barrier (BBB) is an early hallmark of multiple sclerosis (MS), a progressive inflammatory disease of the central nervous system. Cell adhesion in the BBB is modulated by sphingosine-1-phosphate (S1P), a signaling protein, via S1P receptors (S1P\(_1\)). Fingolimod phosphate (FTY720-P) a functional S1P\(_1\) antagonist has been shown to improve the relapse rate in relapsing-remitting MS by preventing the egress of lymphocytes from lymph nodes. However, its role in modulating BBB permeabilityin particular, on the tight junction proteins occludin, claudin 5 and ZO-1has not been well elucidated to date. In the present study, FTY720-P did not change the transendotheli…
Effects of PSD2 on security architecture of mobile banking : a review of literature
2017
This thesis aims to find out the changes that the Payment Service Directive (PSD2) will bring to the security architecture of mobile banking. PSD2 will create a situation where security mechanisms are separated from the actual banking application. Payment service providers must provide their Application Programming Interface for third party developers to give them access to authentication of payment transactions. PSD2 requires payments service providers to offer strong customer authentication with separate authentication mechanism from the banking application. This thesis found that academic literature about the security architecture of mobile banking does not provide a model where a separa…
Half-width plots, a simple tool to predict peak shape, reveal column kinetics and characterise chromatographic columns in liquid chromatography: Stat…
2013
Peak profiles in chromatography are characterised by their height, position, width and asymmetry; the two latter depend on the values of the left and right peak half-widths. Simple correlations have been found between the peak half-widths and the retention times. The representation of such correlations has been called half-width plots. For isocratic elution, the plots are parabolic, although often, the parabolas can be approximated to straight-lines. The plots can be obtained with the half-widths/retention time data for a set of solutes experiencing the same kinetics, eluted with a mobile phase at fixed or varying composition. When the analysed solutes experience different resistance to mas…
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages
2020
Background: During early stages, patients with neurodegenerative diseases (NDG) often present with depressive symptoms. However, because depression is a heterogeneous disorder, more precise delineation of the specific depressive symptom profiles that arise early in distinct NDG syndromes is necessary to enhance patient diagnosis and care. Methods and Findings: Five-hundred and sixty four participants self-reported their depressive symptoms using the Geriatric Depression Scale (GDS), including 111 healthy older control subjects (NC) and 453 patients diagnosed with one of six NDGs who were at the mild stage of disease (CDR® Dementia Staging Instrument ≤ 1) [186 Alzheimer's disease (AD), 76 be…
Pressurized intraperitoneal aerosol chemotherapy with cisplatin and doxorubicin or oxaliplatin for peritoneal metastasis from pancreatic adenocarcino…
2020
Background: Systemic chemotherapy for pancreatic adenocarcinoma (PDAC) and cholangiocarcinoma (CC) with peritoneal metastases (PM) is affected by several pharmacological shortcomings and low clinical efficacy. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is expected to maximize exposure of peritoneal nodules to antiblastic agents. This study aims to evaluate safety and efficacy of PIPAC for PM of PDAC and CC origin. Methods: This is a retrospective analysis of consecutive PDAC and CC cases with PM treated with PIPAC at two European referral centers for peritoneal disease. We prospectively recorded from August 2016 to May 2019 demographic, clinical, surgical, and oncological data…
Nonadiabatic quantum search algorithms
2007
7 pages, 4 figures.-- PACS nrs.: 03.67.Lx, 05.45.Mt, 72.15.Rn.-- ISI Article Identifier: 000251326400049.-- ArXiv pre-print available at: http://arxiv.org/abs/0706.1139
recensione a: GIORGIA BANDINI - CATERINA PENTERICCI (a c. di), Personaggi in scena. Il Parasitus (Ludi Plautini Sarsinates 2), Roma, Carocci 2019
2023
Review to the volume of: GIORGIA BANDINI - CATERINA PENTERICCI (a c. di), Personaggi in scena. Il Parasitus (Ludi Plautini Sarsinates 2), Roma, Carocci 2019
Ruralidad y políticas locales de integración: Estudio comparativo sobre las provincias de Alicante y Valencia
2013
Pese al asentamiento de un número significativo y creciente de migrantes inter a n cio nales en los municipios rurales de los países de rentas altas, existen pocos estudios sobre las políticas de sus autoridades locales en materia de diversidad cultural. Este trabajo pretende abrir el camino examinando algunos motivos teóricos y em píricos para pensar que los ayuntamientos rurales se diferencian de los urbanos en su pro sión a acomodar las prácticas culturales de los inmigrantes, así como en sus pen principales áreas de intervención. El análisis comparativo de 12 municipios de las provincias españolas de Alicante y Valencia sugiere que las políticas de integr…