Search results for "LUTETIUM"
showing 10 items of 40 documents
In Vitro Evaluation of the Squaramide-Conjugated Fibroblast Activation Protein Inhibitor-Based Agents AAZTA5.SA.FAPi and DOTA.SA.FAPi
2021
Recently, the first squaramide-(SA) containing FAP inhibitor-derived radiotracers were introduced. DATA5m.SA.FAPi and DOTA.SA.FAPi with their non-radioactive complexes showed high affinity and selectivity for FAP. After a successful preclinical study with [68Ga]Ga-DOTA.SA.FAPi, the first patient studies were realized for both compounds. Here, we present a new squaramide-containing compound targeting FAP, based on the AAZTA5 chelator 1,4-bis-(carboxylmethyl)-6-[bis-(carboxymethyl)-amino-6-pentanoic-acid]-perhydro-1,4-diazepine. For this molecule (AAZTA5.SA.FAPi), complexation with radionuclides such as gallium-68, scandium-44, and lutetium-177 was investigated, and the in vitro properties of…
Exploiting transport properties for the detection of optical pumping in heavy ions
2020
We present a kinetic model for optical pumping in Lu$^+$ and Lr$^+$ ions as well as a theoretical approach to calculate the transport properties of Lu$^+$ in its ground $^1S_0$ and metastable $^3D_1$ states in helium background gas. Calculations of the initial ion state populations, the field and temperature dependence of the mobilities and diffusion coefficients, and the ion arrival time distributions demonstrate that the ground- and metastable-state ions can be collected and discriminated efficiently under realistic macroscopic conditions.
Laser spectroscopy investigation of the nuclear moments and radii of lutetium isotopes
1998
Collinear laser spectroscopy experiments in the LuI transition $5d6s\!^{2} \; ^{2}\!D_{3/2} \rightarrow 5d6s6p \; ^{2}\!D_{3/2}$ were performed on all lutetium isotopes in the range of $^{161-179}$Lu. The nuclear spins, magnetic moments and quadrupole moments were determined from the hyperfine structures observed for 19 ground states and 11 isomers. Variations in the mean square charge radii as a function of neutron number were obtained from the isotope shifts. These data considerably extend the systematics of the properties of nuclei in the upper rare-earth region. A particular feature is the appearance of high-spin and low-spin ground states and isomeric states in the vicinity of the stab…
High-precision ab initio calculations of the spectrum of Lr$^+$
2019
The planned measurement of optical resonances in singly-ionised lawrencium (Z = 103) requires accurate theoretical predictions to narrow the search window. We present high-precision, ab initio calculations of the electronic spectra of Lr$^+$ and its lighter homologue lutetium (Z = 71). We have employed the state-of-the-art relativistic Fock space coupled cluster approach and the AMBiT CI+MBPT code to calculate atomic energy levels, g-factors, and transition amplitudes and branching-ratios. Our calculations are in close agreement with experimentally measured energy levels and transition strengths for the homologue Lu$^+$ , and are well-converged for Lr$^+$ , where we expect a similar level o…
[177Lu]Lu-DOTA-zoledronate therapy - first application in a patient with primary osseous metastatic bronchial carcinoma.
2020
CCDC 211481: Experimental Crystal Structure Determination
2004
Related Article: S.Arndt, P.M.Zeimentz, T.P.Spaniol, J.Okuda, M.Honda, K.Tatsumi|2003|Dalton Trans.||3622|doi:10.1039/b305964b
CCDC 179962: Experimental Crystal Structure Determination
2002
Related Article: S.Arndt, T.P.Spaniol, J.Okuda|2002|Chem.Commun.||896|doi:10.1039/b201613n
CCDC 1963046: Experimental Crystal Structure Determination
2019
Related Article: Jackson P. Knott, Mikko M. Hanninen, J. Mikko Rautiainen, Heikki M. Tuononen, Paul G. Hayes|2017|J.Organomet.Chem.|845|135|doi:10.1016/j.jorganchem.2017.04.008
CCDC 179961: Experimental Crystal Structure Determination
2002
Related Article: S.Arndt, T.P.Spaniol, J.Okuda|2002|Chem.Commun.||896|doi:10.1039/b201613n
CCDC 2003421: Experimental Crystal Structure Determination
2020
Related Article: Jens Kalmbach, Cui Wang, Yi You, Christoph Förster, Hartmut Schubert, Katja Heinze, Ute Resch-Genger, Michael Seitz|2020|Angew.Chem.,Int.Ed.|59|18804|doi:10.1002/anie.202007200