Search results for "LVH"
showing 6 items of 6 documents
A pilot study of circulating microRNAs as potential biomarkers of Fabry disease
2018
Patients suffering from Fabry disease (FD), a lysosomal storage disorder, show a broad range of symptoms and the diagnosis followed by the therapeutic decision remains a great challenge. The biomarkers available today have not proven to be useful for predicting the evolution of the disease and for assessing response to therapy in many patients. Here, we used high-throughput microRNA profiling methodology to identify a specific circulating microRNA profile in FD patients. We discovered a pattern of 10 microRNAs able to identify FD patients when compared to healthy controls. Notably, two of these: the miR199a-5p and the miR-126-3p are able to discriminate FDs from the control subjects with le…
Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
2021
Abstract It has long been known that blood pressure (BP) is characterized by marked short‐term fluctuations occurring within a 24‐h period and also by long‐term oscillations occurring over more prolonged periods of time. An increased short‐term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24‐h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short‐term …
Effects of drug therapy on cardiac arrhythmias and ischemia in hypertensives with LVH.
2001
Left ventricular hypertrophy (LVH) in hypertensive subjects is associated with an increased prevalence of ventricular arrhythmias. To evaluate the effect of antihypertensive treatment on cardiac arrhythmias (CA) and transient episodes of myocardial ischemia (TEMI), we studied 46 hypertensive patients with LVH, divided into four groups randomly treated with enalapril, hydrochlorothiazide (HCTZ), atenolol, or verapamil (SR-V) for 6 months. Office blood pressure and office heart rate values were recorded, in basal conditions, after 1 and 6 months of treatment, and all patients underwent echocardiography, electrocardiographic Holter monitoring, and stress testing. All drugs significantly lowere…
Sammenhengen mellom selvhandikapping, frykt for å feile og mestringstro i kroppsøving : En kvantitativ undersøkelse blant ungdomsskoleelever på Vestl…
2019
Master grunnskolelærerutdanning for trinn 5-10, 5-årig masterprogram IDR507 - Universitetet i Agder 2019 The purpose of this study was to gain more knowledge about the concepts of self-handicapping, self-efficacy and fear of failure in physical education, and also to investigate potential variation when it comes to school leveland gender among pupils in secondary school.The aimof thisstudy was twofold; 1) to investigate differences in the relevant concepts on the basis of school leveland gender and 2) to investigate relationships between the different concepts. Part 2 is more specifically related to examining the predictive ability of fear of failure and self-efficacy on self-handicapping. …
Long-term effectiveness of agalsidase alfa enzyme replacement in Fabry disease: A Fabry Outcome Survey analysis
2015
Outcomes from 5 years of treatment with agalsidase alfa enzyme replacement therapy (ERT) for Fabry disease in patients enrolled in the Fabry Outcome Survey (FOS) were compared with published findings for untreated patients with Fabry disease. Data were extracted from FOS, a Shire-sponsored database, for comparison with data from three published studies. Outcomes evaluated were the annualized rate of change in estimated glomerular filtration rate (eGFR) and left ventricular mass indexed to height (LVMI) as well as time to and ages at a composite morbidity endpoint and at death. FOS data were extracted for 740 treated patients who were followed for a median of ~ 5 years. Compared with no trea…
"Jeg vil leve mitt liv med å være meg selv" : om selvhevdelse i psykisk helsearbeid
2012
Masteroppgave i psykisk helsearbeid ME-504 2012 – Universitetet i Agder, Grimstad Kommunene har til oppgave å tilby lokalsamfunnet et virkningsfullt psykisk helsearbeid slik at den enkelte innbygger som har behov for det skal få tilbud om best mulig hjelp til å fungere i et krevende samfunn sammen med andre. Sandnes kommune tilbyr blant annet kurs i selvhevdelse til mennesker som har store utfordringer i forhold til å hevde seg selv. Hensikten med denne studien er å finne ut om deltakere erfarer å få bedre psykisk helse etter å ha deltatt på kurs i selvhevdelse. Problemstillingen i studien er ”Hvilke erfaringer har deltakerne med selvhevdelse etter å ha gjennomgått kurs i selvhevdelse?”. Op…