Search results for "LYN"

Standard polynomials and matrices with superinvolutions

2016

Abstract Let M n ( F ) be the algebra of n × n matrices over a field F of characteristic zero. The superinvolutions ⁎ on M n ( F ) were classified by Racine in [12] . They are of two types, the transpose and the orthosymplectic superinvolution. This paper is devoted to the study of ⁎-polynomial identities satisfied by M n ( F ) . The goal is twofold. On one hand, we determine the minimal degree of a standard polynomial vanishing on suitable subsets of symmetric or skew-symmetric matrices for both types of superinvolutions. On the other, in case of M 2 ( F ) , we find generators of the ideal of ⁎-identities and we compute the corresponding sequences of cocharacters and codimensions.

On the reconstruction of discontinuous functions using multiquadric RBF–WENO local interpolation techniques

2020

Abstract We discuss several approaches involving the reconstruction of discontinuous one-dimensional functions using parameter-dependent multiquadric radial basis function (MQ-RBF) local interpolants combined with weighted essentially non-oscillatory (WENO) techniques, both in the computation of the locally optimized shape parameter and in the combination of RBF interpolants. We examine the accuracy of the proposed reconstruction techniques in smooth regions and their ability to avoid Gibbs phenomena close to discontinuities. In this paper, we propose a true MQ-RBF–WENO method that does not revert to the classical polynomial WENO approximation near discontinuities, as opposed to what was pr…

2021

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in …

Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance

2021

Regular colonoscopy even with short intervals does not prevent all colorectal cancers (CRC) in Lynch syndrome (LS). In the present study, we asked whether cancers detected under regular colonoscopy surveillance (incident cancers) are phenotypically different from cancers detected at first colonoscopy (prevalent cancers). We analyzed clinical, histological, immunological and mutational characteristics, including panel sequencing and high-throughput coding microsatellite (cMS) analysis, in 28 incident and 67 prevalent LS CRCs (n total = 95). Incident cancers presented with lower UICC and T stage compared to prevalent cancers (p &lt

Correction:Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrom…

2020

Lynch syndrome (LS) results from pathogenic variants in the mismatch repair (MMR) genes and is the most common hereditary cancer syndrome, affecting an estimated 1 in 300 individuals. Pathogenic variants in each of the MMR genes path_MLH1, path_MSH2, path_MSH6, and path_PMS2 result in different risks for cancers in organs including the colorectum, endometrium, ovaries, stomach, small bowel, bile duct, pancreas, and upper urinary tract. Accurate estimates of these risks are essential for planning appropriate approaches to the prevention or early diagnosis of cancers but the robustness of previous studies has been limited by factors including retrospective design,1,2 lack of validation in ind…

Paraneoplastic motor neuron disease associated with breast cancer.

2014

502P Impact of different selection approaches for identifying Lynch syndrome-related colorectal cancer patients

2021

<i>BRAF</i> Mutation Testing in Lynch Syndrome Diagnostics: Performance and Efficiency According to Patient's Age

2019

Background: BRAF V600E mutations are reportedly associated with sporadic microsatellite-unstable (MSI) colorectal cancer (CRC), while rarely detected in CRCs of Lynch syndrome (LS) patients. Therefore, current international diagnostic guidelines recommend somatic BRAF mutation testing in MLH1-deficient MSI CRC patients to exclude LS. As sporadic BRAF- mutant MSI CRC is a disease of the elderly, while LS-associated CRC usually occurs at younger age, we hypothesized that the efficacy of BRAF testing in LS diagnostics may be age-dependent. Methods: We systematically compared the prevalence of BRAF mutations in LS-associated CRCs and MSI CRCs from population-based cohorts in different age group…

Optical Quality Comparison of Conventional and Hole-Visian Implantable Collamer Lens at Different Degrees of Decentering

2012

To compare the optical quality of implantable Collamer lens (ICL) with and without central hole (Hole ICL and conventional ICL) at different degrees of decentering.Experimental laboratory investigation.Wavefront aberrations of the -3, -6, and -12 diopter (D) V4b and -3, -6, and -12 D V4c ICLs were measured in 3 conditions-centered and decentered 0.3 and 0.6 mm-at 3-mm and 4.5-mm pupils. The root mean square of total higher order aberrations, trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were evaluated. In addition, point spread function and simulated retinal images of ICLs were calculated from the wavefront aberrations for each ICL and all conditions of decenteri…

A PSO algorithm for designing 3d highway alignments adopting polynomial solutions

2017

Intelligent optimization algorithms for highway alignments have produced good results so far. However, considering the numerous constraints and factors directly implied in the infrastructure design, the researchers' efforts usually focus only on simplifying the alignment choice, supporting engineers in the design phase. Implementing strategic considerations regarding comfort and safety would be also very important. In this paper, the authors propose a method for designing improved 3D highway alignments using a specific optimization algorithm, based on a Swarm Intelligence technique, adopting an innovative polynomial transition curve as the unique horizontal curvature element, called PPC (Po…