Search results for "LYN"
showing 10 items of 910 documents
Perheneuvolan työkäytännöt selvitettäessä lapsen seksuaalisen hyväksikäytön epäilyä
1999
Hahmojen välisiä suhteita : interfiguraalisuus Donna Tarttin romaanissa The Secret History
2017
Tutkielma käsittelee interfiguraalisuutta – intertekstuaalisuuden alalajia, joka viittaa eri teksteissä esiintyvien henkilöhahmojen välisiin suhteisiin – Donna Tarttin romaanissa The Secret History. Tarttin romaanin päähenkilöitä tarkastellaan suhteessa neljän muun romaanin henkilöhahmoihin (F. Scott Fitzgeraldin The Great Gatsby, William Goldingin Lord of the Flies, Evelyn Waugh’n Brideshead Revisited sekä Oscar Wilden The Picture of Dorian Gray). Tutkielmassa eri teksteissä esiintyvien henkilöhahmojen välisiä interfiguraalisia kytköksiä peilataan suhteessa The Secret Historyn kertojan luotettavuuteen ja romaanin keskeisiin teemoihin. Tutkimusongelmana on, millaista potentiaalia interfigur…
Single-event effects of space and atmospheric radiation on memory components
2017
Electronic memories are ubiquitous components in electronic systems: they are used to store data, and can be found in all manner of industrial, automotive, aerospace, telecommunication and entertainment systems. Memory technology has seen a constant evolution since the first practical dynamic Random- Access Memories (dynamic RAMs) were created in the late 60's. The demand for ever-increasing performance and capacity and decrease in power consumption was met thanks to a steady miniaturization of the component features: modern memory devices include elements barely a few tens of atomic layers thick and a few hundred of atomic layers wide. The side effect of this constant miniaturization was a…
Secular rise in economically valuable personality traits
2017
Although trends in many physical characteristics and cognitive capabilities of modern humans are well-documented, less is known about how personality traits have evolved over time. We analyze data from a standardized personality test administered to 79% of Finnish men born between 1962 and 1976 (n = 419,523) and find steady increases in personality traits that predict higher income in later life. The magnitudes of these trends are similar to the simultaneous increase in cognitive abilities, at 0.2-0.6 SD during the 15-y window. When anchored to earnings, the change in personality traits amounts to a 12% increase. Both personality and cognitive ability have consistent associations with famil…
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch r…
2022
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This com…
Survival by colon cancer stage and screening interval in Lynch syndrome:a prospective Lynch syndrome database report
2019
Abstract Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR ca…
Onko persoonana oleminen tärkeää?
2007
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treat…
2023
Background: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time.Methods: The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of path_MMR variants fr…
Liikunta-aktiivisuus ikääntyneiden henkilöiden kaatumispelkoa selittävänä tekijänä
2016
Ikääntyneiden henkilöiden kaatumisalttius lisääntyy, kun liikkumiskyky heikkenee. Yli 65-vuotiaista yli kolmannes kaatuu vuosittain ja heistä puolet vuoden sisällä uudelleen. Kaatumiset aikaansaavat usein toimintakyvyn heikkenemisen kierteen, johon kuuluu myös liikunta-aktiivisuuden vähentymistä ja kaatumispelon esiintymistä. Tämän tutkimuksen tarkoituksena oli selvittää, millainen yhteys päivittäisellä kävelyn kilometrimäärällä ja vähintään puolen tunnin yhtäjaksoisten liikuntaharjoittelukertojen useudella on ikääntyneiden henkilöiden kokemaan kaatumispelkoon. Tämän poikkileikkaustutkimuksen aineistona on käytetty KaatumisSeula-hankkeen yhteydessä Seinäjoella kerättyä väestöotoskyselyä (n …