Search results for "Lability"
showing 10 items of 802 documents
On Information Processing in the Cat’s Visual Cortex
1986
We assume that the visual system serves for orientation in space, recognition of objects and the interpretation of scenes and scene sequences. This task breaks up into a series of partially interdependent subproblems which are solved by some 13–15 usually retinotopically organized areas. So far it has not been possible to correlate functions and areas unequivocally. One reason for this could be the inadequacy of the questions posed as a basis for experiments. However, we think it more likely that correlating a function with an area is, as a rule, inadmissible since the degree of the coupling in the whole system does not permit a simple divsion. Rather the type and degree of coupling determi…
Big Data in metagenomics: Apache Spark vs MPI.
2020
The progress of next-generation sequencing has lead to the availability of massive data sets used by a wide range of applications in biology and medicine. This has sparked significant interest in using modern Big Data technologies to process this large amount of information in distributed memory clusters of commodity hardware. Several approaches based on solutions such as Apache Hadoop or Apache Spark, have been proposed. These solutions allow developers to focus on the problem while the need to deal with low level details, such as data distribution schemes or communication patterns among processing nodes, can be ignored. However, performance and scalability are also of high importance when…
Optimal standalone data center renewable power supply using an offline optimization approach
2022
Abstract Because of the increasing energy consumption of data centers and their C O 2 emissions, the ANR DATAZERO2 project aims to design autonomous data centers running solely on local renewable energy coupled with storage devices to overcome the intermittency issue. In order to optimize the use of renewable energy and storage devices, a MILP solver is usually in charge of assigning the power to be supplied to the data center. However, in order to reduce the computation time and make the approach scalable, it would be more appropriate to use a polynomial time algorithm. This paper aims at showing and proving that it is possible to provide an optimal power profile via a deterministic algori…
Antioxidants and Bioactive Compounds in Food: Critical Review of Issues and Prospects
2022
International audience; This review paper gives an insight into the effective delivery mechanisms for health-promoting substances and highlights the challenges of using antioxidants and bioactives in foods. The selection criteria for choosing bioactives and their extraction in bioavailable form with their adequate incorporation techniques and delivery mechanisms are covered. Moreover, an overview of existing methods for determination of bioactivity is given. The importance of scientifically evaluating the effects of foods or food components on consumer health before making claims about the healthiness is aligned. Finally, a scientific perspective on how to respond to the booming demand for …
The role of size and protein shells in the toxicity to algal photosynthesis induced by ionic silver delivered from silver nanoparticles
2019
Abstract Because of their biocide properties, silver nanoparticles (AgNPs) are present in numerous consumer products. The biocidal properties of AgNPs are due to both the interactions between AgNP and cell membranes and the release of dissolved silver (Ag+). Recent studies emphasized the role of different nanoparticle coatings in complexing and storing Ag+. In this study, the availability of dissolved silver in the presence of algae was assessed for three AgNPs with different silver contents (59%, 34% and 7% of total Ag), silver core sizes and casein shell thicknesses. The impact of ionic silver on the photosynthetic yield of Chlamydomonas reinhardtii was used as a proxy to estimate the amo…
Mapreduce in computational biology via hadoop and spark
2017
Bioinformatics has a long history of software solutions developed on multi-core computing systems for solving computational intensive problems. This option suffer from some issues solvable by shifting to Distributed Systems. In particular, the MapReduce computing paradigm, and its implementations, Hadoop and Spark, is becoming increasingly popular in the Bioinformatics field because it allows for virtual-unlimited horizontal scalability while being easy-to-use. Here we provide a qualitative evaluation of some of the most significant MapReduce bioinformatics applications. We also focus on one of these applications to show the importance of correctly engineering an application to fully exploi…
Effect of simulated gastrointestinal digestion on sialic acid and gangliosides present in human milk and infant formulas.
2011
The effects of simulated gastrointestinal digestion upon sialic acid and gangliosides in infant and follow-on formulas and human milk, as well as their bioaccessibility, have been evaluated. The gastric stage is the step that causes a greater decrease in sialic acid and ganglioside contents. The intestinal stage only decreases the total and individual contents of gangliosides. After gastrointestinal digestion, neither sialic acid nor gangliosides were found in the nonbioaccessible fraction. The highest bioaccessibility (100 × content in soluble fraction after gastrointestinal digestion/total content) of sialic acid is found in human milk (87%), followed by infant formula (77%) and follow-on…
Poloxamer/sodium cholate co-formulation for micellar encapsulation of Doxorubicin with high efficiency for intracellular delivery: an in-vitro bioava…
2020
Abstract Hypothesis Doxorubicin hydrochloride (DX) is widely used as a chemotherapeutic agent, though its severe side-effects limit its clinical use. A way to overcome these limitations is to increase DX latency through encapsulation in suitable carriers. However, DX has a high solubility in water, hindering encapsulation. The formulation of DX with sodium cholate (NaC) will reduce aqueous solubility through charge neutralization and hydrophobic interactions thus facilitating DX encapsulation into poloxamer (F127) micelles, increasing drug latency. Experiments DX/NaC/PEO-PPO-PEO triblock copolymer (F127) formulations with high DX content (DX-PMs) have been prepared and characterized by scat…
Calcium, Iron, and Zinc Uptake from Digests of Infant Formulas by Caco-2 Cells
2001
Our aim was to estimate the bioavailability of calcium, iron, and zinc from infant formulas using a model that includes in vitro digestion and a Caco-2 cell culture to estimate the uptake. The cell culture conditions were selected, and uptake assays were carried out first with calcium, iron, and zinc standard solutions, and then with the soluble fraction of enzymatic digests of an adapted milk-based and a soy-based infant formula. It was not possible to measure the uptake of calcium, iron, and zinc from standard solutions added to the cell cultures in amounts similar to those present in infant formula digests with our method. The fact that it was, however, possible in the case of enzymatic …
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Bisoprolol Fumarate
2014
Abstract Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing bisoprolol as the sole active pharmaceutical ingredient (API) are reviewed. Bisoprolol is classified as a Class I API according to the current Biopharmaceutics Classification System (BCS). In addition to the BCS class, its therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability problems are taken into consideration. Qualitative compositions of IR tablet dosage forms of bisoprolol with a marketing authorization (MA) in ICH (Inter…