Search results for "Lability"
showing 10 items of 802 documents
Unveiling the Effect of Magnetic Noise in the Coherence of Single-Molecule Quantum Processors.
2019
Quantum bits (qubits) constitute the most elementary building-blocks of any quantum technology, where information is stored and processed in the form of quantum superpositions between discrete energy levels. In particular, the fabrication of quantum processors is a key long-term goal that will allow us conducting specific tasks much more efficiently than the most powerful classical computers can do. Motivated by recent experiments in which three addressable spin qubits are defined on a potential single-molecule quantum processor, namely the [Gd(H2O)P5W30O110]12− polyoxometalate, we investigate the decohering effect of magnetic noise on the encoded quantum information. Our state-of-the-art m…
Biowaiver monographs for immediate release solid oral dosage forms: quinidine sulfate.
2009
Literature data are reviewed relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing quinidine sulfate. Quinidine sulfate's solubility and permeability, its therapeutic use and index, pharmacokinetics, excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. The available data are not fully conclusive, but do suggest that quinidine sulfate is highly soluble and moderately to highly permeable and would likely be assigned to BCS Class I (or at worst BCS III). In view of the inconclusiveness of the data and, more imp…
Transintestinal secretion of ciprofloxacin, grepafloxacin and sparfloxacin: in vitro and in situ inhibition studies.
2003
The influence of the secretion process on the absorption of ciprofloxacin, grepafloxacin and sparfloxacin has been evaluated by means of inhibition studies. Two well known P-glycoprotein inhibitors (cyclosporine, verapamil), a mixed inhibitor of P-glycoprotein and the organic cation transporter OCT1 (quinidine) and a well established MRP substrate (p-aminohipuric acid) have been selected in order to distinguish the possible carriers implicated. An in situ rat gut perfusion model and CACO-2 permeability studies are used. Both methods suggest the involvement of several types of efflux transporters for every fluoroquinolone. The relevance of the secretory pathway depends on the intrinsic perme…
NVMM-Oriented Hierarchical Persistent Client Caching for Lustre
2021
In high-performance computing (HPC), data and metadata are stored on special server nodes and client applications access the servers’ data and metadata through a network, which induces network latencies and resource contention. These server nodes are typically equipped with (slow) magnetic disks, while the client nodes store temporary data on fast SSDs or even on non-volatile main memory (NVMM). Therefore, the full potential of parallel file systems can only be reached if fast client side storage devices are included into the overall storage architecture. In this article, we propose an NVMM-based hierarchical persistent client cache for the Lustre file system (NVMM-LPCC for short). NVMM-LPC…
Successive Reduction of Arms in Multi-Armed Bandits
2011
The relevance of the multi-armed bandit problem has risen in the past few years with the need for online optimization techniques in Internet systems, such as online advertisement and news article recommendation. At the same time, these applications reveal that state-of-the-art solution schemes do not scale well with the number of bandit arms. In this paper, we present two types of Successive Reduction (SR) strategies - 1) Successive Reduction Hoeffding (SRH) and 2) Successive Reduction Order Statistics (SRO). Both use an Order Statistics based Thompson Sampling method for arm selection, and then successively eliminate bandit arms from consideration based on a confidence threshold. While SRH…
Cloud Infrastructure for Skin Cancer Scalable Detection System
2018
Skin cancer diagnostics is one of the medical areas where early diagnostic allows achieving patients’ high survival rate. Typically, skin cancer diagnostic is performed by dermatologist, since the amount of such specialists is limited, mortality rate is high [1]. By creating the low cost and easy to use diagnostic device, it is possible to bring skin cancer diagnostic to primary care physicians and allow to check much more persons and diagnose skin cancer on the early stages. There are several existing devices, that provide skin cancer diagnostics [2]. Most of them process the skin images locally and have limited diagnostic capabilities; some of them send images to dermatologists for manual…
System Times and Channel Availability for Secondary Transmissions in CRNs: A Dependability Theory based Analysis
2017
[EN] Reliability is of fundamental importance for the performance of secondary networks in cognitive radio networks (CRNs). To date, most studies have focused on predicting reliability parameters based on prior statistics of traffic patterns from user behavior. In this paper, we define a few reliability metrics for channel access in multichannel CRNs that are analogous to the concepts of reliability and availability in classical dependability theory. Continuous-time Markov chains are employed to model channel available and unavailable time intervals based on channel occupancy status. The impact on user access opportunities based on channel availability is investigated by analyzing the stead…
An information systems design product theory for the class of integrated requirements and release management systems
2010
High-tech companies conducting product development need to collect and analyze requirements effectively, plan and implement releases, and allocate requirements to appropriate releases. Requirements and release management are complicated because development activities typically are scattered across multiple sites, involve multiple partners in different countries, leverage various development methods and tools, and are realized through various organizational arrangements such as release projects in organizations structured around products and permanent release teams in organizations responsible for the long-term development and maintenance of strategic software and hardware assets. Flexible, …
Iron bioavailability in iron-fortified cereal foods: The contribution of in vitro studies
2015
Iron deficiency anemia is the most common nutritional deficiency in humans. Not all dietary ingested iron, heme or nonheme, will be available to absorption and negative imbalance between iron requirements and absorption leads to iron deficiency and/or anemia. The recommended iron values usually are based on the genetic and on diet iron-bioavailability, which can be considered as the principal factor that change among the cultures and influences the distinct levels of recommendation among countries. Dietary changes present practical limitations due to be difficult to change food habits. The iron food fortification is considered more cost effective and economically more attractive than iron s…
Cost-Efficient On-Chip Routing Implementations for CMP and MPSoC Systems
2011
[EN] The high-performance computing domain is enriching with the inclusion of networks-on-chip (NoCs) as a key component of many-core (CMPs or MPSoCs) architectures. NoCs face the communication scalability challenge while meeting tight power, area, and latency constraints. Designers must address new challenges that were not present before. Defective components, the enhancement of application-level parallelism, or power-aware techniques may break topology regularity, thus, efficient routing becomes a challenge. This paper presents universal logic-based distributed routing (uLBDR), an efficient logic-based mechanism that adapts to any irregular topology derived from 2-D meshes, instead of usi…