Search results for "Lability"
showing 10 items of 802 documents
Finding near-perfect parameters for hardware and code optimizations with automatic multi-objective design space explorations
2012
Summary In the design process of computer systems or processor architectures, typically many different parameters are exposed to configure, tune, and optimize every component of a system. For evaluations and before production, it is desirable to know the best setting for all parameters. Processing speed is no longer the only objective that needs to be optimized; power consumption, area, and so on have become very important. Thus, the best configurations have to be found in respect to multiple objectives. In this article, we use a multi-objective design space exploration tool called Framework for Automatic Design Space Exploration (FADSE) to automatically find near-optimal configurations in …
A parallel and sensitive software tool for methylation analysis on multicore platforms.
2015
Abstract Motivation: DNA methylation analysis suffers from very long processing time, as the advent of Next-Generation Sequencers has shifted the bottleneck of genomic studies from the sequencers that obtain the DNA samples to the software that performs the analysis of these samples. The existing software for methylation analysis does not seem to scale efficiently neither with the size of the dataset nor with the length of the reads to be analyzed. As it is expected that the sequencers will provide longer and longer reads in the near future, efficient and scalable methylation software should be developed. Results: We present a new software tool, called HPG-Methyl, which efficiently maps bis…
Long read alignment based on maximal exact match seeds
2012
Abstract Motivation: The explosive growth of next-generation sequencing datasets poses a challenge to the mapping of reads to reference genomes in terms of alignment quality and execution speed. With the continuing progress of high-throughput sequencing technologies, read length is constantly increasing and many existing aligners are becoming inefficient as generated reads grow larger. Results: We present CUSHAW2, a parallelized, accurate, and memory-efficient long read aligner. Our aligner is based on the seed-and-extend approach and uses maximal exact matches as seeds to find gapped alignments. We have evaluated and compared CUSHAW2 to the three other long read aligners BWA-SW, Bowtie2 an…
Basing the Analysis of Comparative Bioavailability Trials on an Individualized Statistical Definition of Equivalence
1993
The conventional definition of bioequivalence in terms of population means only, is criticized for lacking relevance to the individual subject. Both approaches to bioequivalence assessment proposed here for avoiding this shortcoming, focus on the probability of an event induced by the response of a randomly selected subject to two formulations of a given active agent. The first approach leads to converting the basic idea underlying the well-known 75-rule into an exact statistical procedure. The second approach is of a parametric nature. It reduces bioequivalence assessment to testing against the alternative hypothesis that the standardized expected value of a Gaussian distribution is contai…
Probing the non-innocent nature of an amino-functionalised β-diketiminate ligand in silylene/iminosilane systems.
2020
Electron-rich β-diketiminate ligands, featuring amino groups at the backbone β positions (“N-nacnac” ligands) have been employed in the synthesis of a range of silylene (SiII) complexes of the type (N-nacnac)SiX (where X = H, Cl, N(SiMe3)2, P(SiMe3)2 and Si(SiMe3)3). A combination of experimental and quantum chemical approaches reveals (i) that in all cases rearrangement to give an aza-butadienyl SiIV imide featuring a contracted five-membered heterocycle is thermodynamically favourable (and experimentally viable); (ii) that the kinetic lability of systems of the type (N-nacnac)SiX varies markedly as a function of X, such that compounds of this type can be isolated under ambient conditions …
Assessment of Modelling Structure and Data Availability Influence on Urban Flood Damage Modelling Uncertainty
2014
Abstract In modelling application, different model structures may be equally reliable in terms of calibration ability but they may produce different uncertainty levels; moreover, available data during model calibration may influence the uncertainty linked to the predictions of the same modelling structure. In the present paper, Bayesian model-averaging was applied to several flood damage estimation models in order to identify the best model combination for urban flooding distribution analysis in Palermo city center (Italy). During the analysis, was taken into account the effect of the available data growth on the model uncertainty with respect to the different combination of models outputs.
An analysis of ego network communities and temporal a affinity for online social networks
2017
The wide diffusion of Online Social Networks (OSNs) presents several advantages, like the definition of simple tools for information sharing and spreading. However, OSNs present also some drawbacks, one of the most important one is the problem of privacy disclosures. Distributed Online Social Networks (DOSNs), which decentralize the control of the social network, have been recently proposed to overcome these issues. The decentralization of the control has issued several challenges, one of the main ones is guaranteeing data availability without relying on a central server. To define users’ data allocation strategies, the knowledge of the structure of the ego network and of the user’ temporal…
Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegr…
2021
Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by…
Petro-mineralogical controls on coda attenuation in volcanic rock samples
2021
SUMMARY Seismic attenuation measurements, especially those obtained from coda decay analysis, are becoming a key data source for the characterization of the heterogeneous Earth due to their sensitivity to small-scale heterogeneities. However, the relation between the scattering attenuation measured from coda waves and physical rock properties is still unclear. The goal of this study is to identify the main petrophysical and mineralogical factors controlling coda attenuation in volcanic rocks at the laboratory scale, as a necessary step before modelling seismic waves in real volcanic media. Coda wave attenuation was estimated from ultrasonic S-wave waveforms. To quantify the heterogeneity of…
The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir
2019
Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir's bioaccessibility was studied using the dynamic TNO gastro-Intestinal Model (TIM-1). Four epithelial models were used for permeability experiments: a Caco-2 cell model in absence and presence of mucus and both rat and porcine excised intestinal segments. Study concentrations of acyclovir (0.8 g/l) and chitosan (1.6 g/l and 4 g/l) were in line with t…