Search results for "Lag"

showing 10 items of 3124 documents

Neoproterozoic Rosetta Gabbro from northernmost Arabian–Nubian Shield, south Jordan : Geochemistry and petrogenesis

2017

An Ediacaran mafic intrusion of south Jordan is a distinctive appinitic igneous rock with a possibly unique texture, characterized by spherical clots up to 40 mm in diameter composed of amphibole cores from which plagioclase euhedra radiate; we call it the Rosetta Gabbro. It is exposed as a small (ca. 750 m(2)) outcrop in the Neoproterozoic basement of south Jordan. A second outcrop of otherwise similar gabbro is located about 400 m to the north of the Rosetta Gabbro, but it lacks the distinctive texture. The Rosetta Gabbro could represent a magma pipe. It intrudes the Aqaba Complex (similar to 600 Ma) granitoids and metasediments of the Janub Metamorphic Complex (633-617 Ma). The gabbro is…

Amphibole microchemistry010504 meteorology & atmospheric sciencesGeochemistryRosetta Gabbroengineering.material010502 geochemistry & geophysicsAppinite01 natural sciencesMagmatic waterGeochemistry and PetrologyPlagioclaseLA-ICP-MSAmphibole0105 earth and related environmental sciencesBasaltGabbroGeovetenskap och miljövetenskapGeologyArabian-Nubian shieldIgneous rockWater-rich magmaMagmaengineeringMaficEarth and Related Environmental SciencesGeology
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Negative staining across holes: application to fibril and tubular structures.

2007

The negative staining technique, when used with holey carbon support films, presents superior imaging conditions than is the case when samples are adsorbed to continuous carbon films. A demonstration of this negative staining approach is presented, using ammonium molybdate in combination with trehalose, applied to several fibrillar and tubular samples. Fibrils formed from the amyloid-beta peptide and the protease inhibitor pepstain A spread very well unsupported across holes and the different polymorphic fibril forms can be readily assessed. However, tubular forms of amyloid-beta have a tendency to be flattened, due to surface tension forces prior to and during specimen drying. Sub-fibril a…

AmyloidMaterials scienceGeneral Physics and Astronomychemistry.chemical_elementFibrilNegative Stainingchemistry.chemical_compoundFerrihydriteMicroscopy Electron TransmissionStructural BiologyIron-Binding ProteinsPepstatinsAnimalsHumansNanotechnologyGeneral Materials ScienceAmmonium molybdateMolybdenumAmyloid beta-PeptidesProteinsTrehaloseCell BiologyDNATrehaloseNegative stainCarbonStainingRatsCrystallographyCarbon filmchemistryBiophysicsCollagenPeptidesCarbonMicron (Oxford, England : 1993)
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Experimental alteration of granitic rocks: Implications for the evolution of geothermal brines in the Upper Rhine Graben, Germany

2020

Abstract Geothermal energy exploitation in the Upper Rhine Graben (URG) chiefly has targeted faults and fractures within or connected with the crystalline basement, where hot fluids of c. 200 °C circulate at depths of c. 5 km. Formation fluids of the crystalline basement are highly saline, NaCl-dominated brines, whereas shallow crystalline basement water ( The trace element concentrations of the leachates are hereby related to the composition and stability of minerals in the rocks and can be directly linked to the proposed and observed dissolution processes at the different temperatures. In experiments with pure water at 70 °C, representing the recharge or infiltration conditions, water-roc…

AnalcimeRenewable Energy Sustainability and the EnvironmentChemistry0211 other engineering and technologiesGeochemistryGeology02 engineering and technologyengineering.material010502 geochemistry & geophysicsGeotechnical Engineering and Engineering GeologyFeldspar01 natural sciencesvisual_artIllitevisual_art.visual_art_mediumengineeringKaolinitePlagioclase021108 energyQuartzDissolutionBiotite0105 earth and related environmental sciencesGeothermics
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Priming with proangiogenic growth factors and endothelial progenitor cells improves revascularization in linear diabetic wounds

2014

In the present study, we investigated whether proangiogenic growth factors and endothelial progenitor cells (EPCs) induce favourable effects on cutaneous incisional wound healing in diabetic mice. The proangiogenic effects of human EPCs were initially analyzed using a HUVEC in vitro angiogenesis assay and an in vivo Matrigel assay in nude mice (n=12). For the diabetic wound model, 48 Balb/c mice with streptozotocin (STZ)-induced diabetes were divided randomly into 4 groups (12 mice in each group). Subsequently, 3, 5 and 7 days before a 15-mm full-thickness incisional skin wound was set, group 1 was pre-treated subcutaneously with a mixture of vascular endothelial growth factor (VEGF)/basic …

Angiogenesismedicine.medical_treatmentBasic fibroblast growth factorMice NudeNeovascularization Physiologicwound healingdiabetic miceDiabetes Mellitus ExperimentalAndrologychemistry.chemical_compoundMiceTensile StrengthGeneticsHuman Umbilical Vein Endothelial CellsMedicineAnimalsHumansProgenitor cellprimingendothelial progenitor cellsMatrigelMice Inbred BALB Cbiologybusiness.industryGrowth factorStem CellsEndothelial CellsGeneral MedicineArticlesVascular endothelial growth factorproangiogenicDrug CombinationschemistryImmunologyMicrovesselsbiology.proteincardiovascular systemIntercellular Signaling Peptides and ProteinsBiological AssayProteoglycansCollagenLamininbusinessWound healingPlatelet-derived growth factor receptorStem Cell TransplantationInternational Journal of Molecular Medicine
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On the timing properties of SAX J1808.4-3658 during its 2015 outburst

2017

We present a timing analysis of the 2015 outburst of the accreting millisecond X-ray pulsar SAX J1808.4-3658, using non-simultaneous XMM-Newton and NuStar observations. We estimate the pulsar spin frequency and update the system orbital solution. Combining the average spin frequency from the previous observed, we confirm the long-term spin down at an average rate $\dot{\nu}_{\text{SD}}=1.5(2)\times 10^{-15}$ Hz s$^{-1}$. We also discuss possible corrections to the spin down rate accounting for mass accretion onto the compact object when the system is X-ray active. Finally, combining the updated ephemerides with those of the previous outbursts, we find a long-term orbital evolution compatibl…

Angular momentumAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesLagrangian pointAstrophysicsCompact star01 natural sciencespulsars: individual: SAX J1808.4-3658Gravitationstars: neutronX-rays: binariesSettore FIS/05 - Astronomia E AstrofisicaPulsar0103 physical sciences010303 astronomy & astrophysicsHigh Energy Astrophysical Phenomena (astro-ph.HE)Physics010308 nuclear & particles physicsGravitational waveAstronomy and AstrophysicsOrbital periodaccretion accretion discs; stars: neutron; pulsars: individual: SAX J1808.4-3658; X-rays: binaries13. Climate actionSpace and Planetary ScienceQuadrupole:accretion accretion discAstrophysics::Earth and Planetary AstrophysicsAstrophysics - High Energy Astrophysical Phenomena
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Solution of the Skyrme-Hartree–Fock–Bogolyubovequations in the Cartesian deformed harmonic-oscillator basis. (VIII) hfodd (v2.73y): A new version of …

2017

We describe the new version (v2.73y) of the code HFODD which solves the nuclear Skyrme Hartree-Fock or Skyrme Hartree-Fock-Bogolyubov problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we have implemented the following new features: (i) full proton-neutron mixing in the particle-hole channel for Skyrme functionals, (ii) the Gogny force in both particle-hole and particle-particle channels, (iii) linear multi-constraint method at finite temperature, (iv) fission toolkit including the constraint on the number of particles in the neck between two fragments, calculation of the interaction energy between fragments, and calculation of the nuclear and Coulomb ene…

Angular momentumNuclear Theory[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th]SYMMETRYNuclear TheoryHartree–Fock methodGeneral Physics and AstronomyFOS: Physical sciencesGogny forceSkyrme interactionNuclear density functional theorySelf-consistent mean-field01 natural sciences114 Physical sciencesNuclear Theory (nucl-th)Energy density functional theorySYSTEMSQuantum mechanics0103 physical sciences010306 general physicsHarmonic oscillator[ PHYS.NUCL ] Physics [physics]/Nuclear Theory [nucl-th]PhysicsHartree–Fock–Bogolyubovta114010308 nuclear & particles physicsAugmented Lagrangian methodInteraction energyAngular-momentum projection113 Computer and information sciencesHardware and ArchitecturePairingIsospintheoretical nuclear physicsSelf-consistent mean fieldHartree-Fock-BogolyubovPairing correlations
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Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.

2007

International audience; Glycogen synthase 2 (Gys-2) is the ratelimiting enzyme in the storage of glycogen in liver and adipose tissue, yet little is known about regulation of Gys-2 transcription. The peroxisome proliferator-activated receptors (PPARs) are transcription factors involved in the regulation of lipid and glucose metabolism and might be hypothesized to govern glycogen synthesis as well. Here, we show that Gys-2 is a direct target gene of PPARalpha, PPARbeta/delta and PPARgamma. Expression of Gys-2 is significantly reduced in adipose tissue of PPARalpha-/-, PPARbeta/delta-/- and PPARgamma+/- mice. Furthermore, synthetic PPARbeta/delta, and gamma agonists markedly up-regulate Gys-2…

Animals; Chromatin/ultrastructure; DNA Primers; Gene Expression Regulation Enzymologic; Glycogen Synthase/genetics; Hepatocytes/enzymology; Hepatocytes/physiology; Mice; Mice Knockout; Peroxisome Proliferator-Activated Receptors/deficiency; Peroxisome Proliferator-Activated Receptors/genetics; Polymerase Chain Reaction; RNA/genetics; RNA/isolation & purification; Rats; Transcription GeneticTranscription GeneticPeroxisome proliferator-activated receptorMESH : HepatocytesPPREPolymerase Chain Reactionadipose-tissuePPARMESH: HepatocytesMice0302 clinical medicineMESH: Animals610 Medicine & healthchemistry.chemical_classificationRegulation of gene expression0303 health sciencesGlycogenglycogen-synthaseChromatinGlycogen Synthase030220 oncology & carcinogenesisMESH : DNA PrimersmicroarrayMESH: DNA Primersmedicine.medical_specialtyHealth aging / healthy living [IGMD 5]fatty-acid oxidationliverGene Expression Regulation EnzymologicMESH: Chromatin03 medical and health sciencesskeletal-muscleGlycogen synthaseMolecular Biology[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyHNF4αVLAGPharmacologybeta/deltaMESH: Polymerase Chain Reactionresponse elementsMESH : Peroxisome Proliferator-Activated ReceptorsEndocrinologychemistryMicrobial pathogenesis and host defense [UMCN 4.1]Response elementPeroxisome Proliferator-Activated ReceptorsAdipose tissueMESH: Peroxisome Proliferator-Activated Receptorsin-vivoMESH: Mice KnockoutTransactivationchemistry.chemical_compoundVoeding Metabolisme en GenomicaMESH : RNAMESH : Polymerase Chain ReactionMice KnockoutMESH : ChromatinMESH : RatsMESH: Gene Expression Regulation EnzymologicMetabolism and Genomicsadipose tissueMetabolisme en GenomicaMolecular MedicineNutrition Metabolism and GenomicsMESH : Glycogen SynthaseResearch ArticleMESH: Ratsglycogen synthase 2610 Medicine & healthBiologyMESH : Gene Expression Regulation EnzymologicCellular and Molecular NeuroscienceVoedingMESH: RNAInternal medicineMESH : MicemedicineAnimals[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyTranscription factorMESH: Micealpha ppar-alpha030304 developmental biologyNutritionDNA PrimersMESH: Glycogen SynthaseMESH: Transcription GeneticMESH : Transcription GeneticCell BiologyRatsgene transcriptionbiology.proteinHepatocytesRNAMESH : Mice KnockoutgammaMESH : Animalsmetabolism
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Collagens in the injured porcine intervertebral disc

1994

Spinal pain often is thought to be due to degeneration and mechanical failure of the intervertebral disc. Since the mechanical strength of the tissue depends on collagen fibers, the present study was designed to investigate the reactions in collagen metabolism after an experimentally induced disc injury. Five domestic pigs underwent an incision in the anterior part of the annulus fibrosus of disc L4-L5 through a retroperitoneal approach. The animals were killed 3 months postoperatively, and the injured discs and intact discs (controls) from different animals were removed for chemical analysis. Slices were cut from seven different parts across the disc. The concentration of total collagen (h…

Annulus (mycology)030222 orthopedicsPathologymedicine.medical_specialtyGranulation tissueIntervertebral discDegeneration (medical)Anatomy03 medical and health sciencesHydroxyprolinechemistry.chemical_compoundIntervertebral disk0302 clinical medicinemedicine.anatomical_structurechemistryCollagen metabolismmedicineOrthopedics and Sports MedicineNucleus030217 neurology & neurosurgeryJournal of Orthopaedic Research
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Modelagem da cinética de secagem de discos de maçã e abobrinha impregnadas a vácuo com antocianinas

2019

ABSTRACT: The aim of this research was to study the drying kinetics of apple and zucchini slices enriched with anthocyanins and to evaluate the influence of drying temperature on the anthocyanin content of apple and zucchini snacks. Apple (Granny Smith) and zucchini (Cucurbita pepo) slices were enriched with anthocyanins by vacuum impregnation with blueberry juice. Then, slices were dehydrated at 40, 50 and 60 ºC with 1.0 m/s air flow. Dehydrated samples were referred to as anthocyanin enriched snacks. Diffusion coefficient values improved by increasing the drying temperature, within the 2.81×10-10 to 5.78×10-10 m2/s range for apple slices and 2.02×10-10 to 3.99×10-10 m2/s for zucchini slic…

AnthocyaninFunctional snackDrying kineticcinética de secagemfunctional snackslcsh:AgricultureCucurbita pepochemistry.chemical_compoundAir dryingmodelagem matemáticalcsh:Agriculture (General)drying kineticsGeneral VeterinarybiologyChemistry0402 animal and dairy sciencemathematical modelinglcsh:S04 agricultural and veterinary sciencesbiology.organism_classification040201 dairy & animal scienceanthocyaninslcsh:S1-972Horticulturesnacks funcionaisAnthocyanin040103 agronomy & agriculture0401 agriculture forestry and fisheriesMathematical modelingAnimal Science and ZoologyantocianinasTecnologia dels alimentsAgronomy and Crop ScienceCiência Rural
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Bioactive Steroidal Saponins from Smilax medica

2006

Two new spirostanol saponins ( 1 and 2) were isolated from the roots of Smilax medica, together with the known smilagenin 3-O-beta-D-glucopyranoside (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR experiments. Compounds 1 and 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs between 6.25 and 50 microg/mL) whereas 3 was inactive.

AntifungalAntifungal AgentsMagnetic Resonance Spectroscopymedicine.drug_classSmilageninSaponinPharmaceutical ScienceMicrobial Sensitivity TestsPharmacognosyAnalytical ChemistryDrug DiscoverymedicineCandida albicansCandidaPharmacologychemistry.chemical_classificationbiologyTraditional medicineLiliaceaeOrganic ChemistrySmilaxSaponinsbiology.organism_classificationComplementary and alternative medicinechemistrySmilaxMolecular MedicinePlanta Medica
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