Search results for "Lag"

Strong Cooperativity and Loose Geometry between CUB Domains Are the Basis for Procollagen C-Proteinase Enhancer Activity

2009

Procollagen C-proteinase enhancers (PCPE-1 and -2) specifically activate bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family during C-terminal processing of fibrillar collagen precursors. PCPEs consist of two CUB domains (CUB1 and CUB2) and one NTR domain separated by one short and one long linker. It was previously shown that PCPEs can strongly interact with procollagen molecules, but the exact mechanism by which they enhance BMP-1 activity remains largely unknown. Here, we used a series of deletion mutants of PCPE-1 and two chimeric constructs with repetitions of the same CUB domain to study the role of each domain and linker. Out of all the forms teste…

Timing in methods for studying psychosocial factors at work

2014

In the present chapter we focus on time lags in panel studies investigating psychosocial factors and stressor-strain relationships. First, a framework of theoretical reasons for choosing specific time lags is provided, which is based on the work by Frese and Zapf (Methodological issues in the study of work stress: objective vs. subjective measurement of work stress and the question of longitudinal studies. In: Cooper CL, Payne R (eds) Causes, coping and consequences of stress at work. Wiley, Chichester, pp 375–411, 1988). Although this theoretical framework provides a clear rationale for time intervals, researchers are frequently mistaken using it to derive appropriate time lags. Second, an…

Negotiating a transnational career around borders: Women's stories in boundaryless academia

2021

The study aimed to give voice to two women sport scientists' life stories to centralize the challenges and ways of coping their career journeys entailed, and enlighten our understanding of the lived experience and meaning of academic migrating. They shared transnational career stories through interviews and ongoing conversations which we re-story in a creative non-fiction story where we blended the two. Our data collection, analysis and representation were informed by theoretical, methodological and interpretive bricolage. As the creative non-fiction story shows, the academic entrepreneur ideal was somewhat disrupted in the women's lives, as migration experiences, aside from thrills, also i…

Morphometric Discriminant Analysis of isolated chondrichthyan scales for palaeoecological inferences: the Middle Triassic of the Iberian Chain (Spain…

2014

[EN] Palaeontological studies on exosqueletal disarticulated remains of chondrichthyans have focused on teeth and only less interest has been paid to scales due their limited taxonomic and systematic significance. However, classical works linking the morphology and the function of the squamation in extant sharks suggest that, despite their limited taxonomic value, the study of isolated scales can be a useful tool for palaeoenvironmental and palaeoecological inferences. Following this idea, we have analyzed the fossil record of shark scales from two Middle Triassic sections of the Iberian Chain (Spain), identifying different functional types by means of a morphometric discriminant analysis. …

How Can World Leaders Understand the Perverse Core of Terrorism?

2017

Based on the recently-dated terrorist attacks perpetrated in Europe, where terrorists weaponized classic forms of transport against civilian targets, one might speculate that likely mobilities and terrorism would be inextricably intertwined. In the mid of this mayhem, this chapter centers on the mobilities-paradigm as an ideological platform that keeps the interests of ruling elite, inasmuch as only 1% of mankind is legally authorized to travel worldwide. It is vital for social scientists to interrogate on the cultural effects of 9/11, in a world which is characterized by serious economic imbalances. In this world of full contrasts, while first world tourists are encouraged to move from one…

Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis.

2006

Ustilago maydis is a ubiquitous pathogen of maize and a well-established model organism for the study of plant-microbe interactions. This basidiomycete fungus does not use aggressive virulence strategies to kill its host. U. maydis belongs to the group of biotrophic parasites (the smuts) that depend on living tissue for proliferation and development. Here we report the genome sequence for a member of this economically important group of biotrophic fungi. The 20.5-million-base U. maydis genome assembly contains 6,902 predicted protein-encoding genes and lacks pathogenicity signatures found in the genomes of aggressive pathogenic fungi, for example a battery of cell-wall-degrading enzymes. Ho…

Illegal fishing in Isla del Coco National Park: Spatial-temporal distribution and the economic trade-offs

2020

Abstract The Isla del Coco National Park, located on the Pacific coast of Costa Rica, is rich in biodiversity and has a high concentration of pelagic species. This high marine biodiversity makes the Isla del Coco National Park (PNIC) a very attractive place for illegal fishers. We analyzed a dataset covering 8 years (2003–2010) of patrol records from PNIC with the aim of determining, a) the spatial-temporal distribution of illegal fishing, b) other areas that could be prone to illegal fishing but are currently undetected, c) the most profitable areas for this activity and d) the economic trade-offs of this illegal activity in relation to potential gains and the costs. Residuals Autocovariat…

L’armonizzazione europea nella lotta al riciclaggio: un’indagine sullo spazio riservato ai diritti e ai principi del diritto penale

2019

La ri-composizione del territorio / The ricomposition of territory

2017

Il saggio, inserito nel volume di sintesi della ricerca PRIN 2009 (“Dalla campagna urbanizzata alla : le norme compositive dell’architettura nel territorio dei centri minori”) presenta alcune aspetti fondamentali del lavoro svolto dall’unità di ricerca locale dell’Università degli Studi di Palermo (responsabile prof.. A. Margagliotta) che ha studiato l’attraverso interno Palermo-Agrigento e il ruolo dell’infrastruttura stradale in rapporto alla questione dei centri minori e della campagna. In particolare il saggio mette approfondisce il tema dei luoghi dell’attraversamento e il ruolo delle infrastrutture; la questione della la campagna e della sua capacità rigenerante nei confronti della re…

Synthèse de ligands macrocycliques comportant des fragments aromatiques et leur application pour la détection des cations métalliques

2011

The PhD thesis deals with the synthesis of polyazaligands using Pd-catalyzed amination of aryl halides. The manuscript consists of two parts. In the first part the scope of the Pd-catalyzed amination reaction for the synthesis of polyazamacrocyclic ligands is studied. The Pd-catalyzed amination of 2,7-dibromonaphthalene, 3,3’-dibromobiphenyl and 6,6’-dibromo-2,2’-bipyridyl with linear polyamines and oxadiamines is thoroughly investigated, and corresponding nitrogen- and oxygen-containing macrocycles is synthesized in yields up to 45%. The dependence of the formation of macrocycles and cyclic oligomers on the nature of the starting compounds is established. Two alternative approaches to cycl…