Search results for "Lama"

Analysis of Rescue Medication Use over 1 Year in Patients Receiving LAMA, LABA, or Combination Maintenance Treatment for COPD in the TONADO Studies

2017

One-year follow up of asthmatic patients newly initiated on treatment with medium- or high-dose inhaled corticosteroid-long-acting β2-agonist in UK p…

2020

Abstract Introduction Global Initiative for Asthma (GINA) recommends medium- or high-dose inhaled corticosteroid-long-acting β2-agonist (ICS-LABA) as preferred treatments for patients with moderate-to-severe asthma. Limited data is available on how step 4/5 patients respond to ICS-LABA and how they step up/down in clinical practice. Methods This retrospective cohort study assessed the characteristics, control status, treatment pathways, and healthcare resource utilization in patients with asthma during one year after initiating medium- or high-dose ICS-LABA. Data from the United Kingdom Clinical Practice Research Datalink were analysed between January 01, 2006 and February 28, 2016. Results…

Indacaterol/glycopyrronium/mometasone fixed dose combination for uncontrolled asthma

2021

INTRODUCTION Asthma symptoms can be relieved through a maintenance treatment combining long-acting β2-agonist and inhaled corticosteroids (LABA/ICS). However, for patients with inadequately controlled asthma, the LABA/ICS combination might not be sufficient. Under these conditions, clinical guidelines recommend the administration of inhaled long-acting muscarinic antagonists (LAMA) as an add-on therapy to LABA/ICS to better control asthma and improve lung function. For nearly two decades, the only LAMA to be approved on the market has been tiotropium. AREAS COVERED We reviewed recent clinical studies evaluating the safety and efficacy of LABA/LAMA/ICS fixed dose combinations by searching Pu…

L’ARTE MASSIMA, Vol. I La rappresentativa nel novo stile: norme e pratica del metodo italiano di recitazione (1728-1860)

2017

Luigi Bonazzi scrive nel suo avviso “ai lettori”che in generale «l’attore drammatico porta tutto se stesso nella tomba» . Quanta romantica affabulazione in tale assunto! Peccato che Bonazzi non abbia detto la verità!Gli attori della rappresentativa e del novo stile non solo non portarono via con sé il segreto della loro arte ma ci hanno lasciato una documentazione più che cospicua, tale da consentirci di riscoprirne sia le normative sia le regole d’applicazione. Sebbene in alcuni studi di qualche anno fa sulla recitazione ottocentesca si sia notato che nei copioni ci sono segni che potrebbero far parte di convenzioni codificate , non si è poi ulteriormente indagato per comprenderne il signi…

Narrazione in drammatica: le scene “raccontate” dai capocomici italiani

2016

Nell’Ottocento i maggiori capocomici italiani, attori e attrici, ebbero un ruolo rilevante nella recezione del teatro di Shakespeare, non solamente sulle scene italiane ma anche sui palcoscenici di tutto il mondo, dove gli stessi vennero annoverati tra i più grandi interpreti del loro tempo. Richard Ellman ricorda appropriatamente, nella sua biografia di James Joyce, come lo scrittore irlandese fosse stato un fervente ammiratore di Eleonora Duse (1858-1924): l’aveva vista per la prima volta recitare nella Gioconda di Gabriele d’Annunzio, durante una sua visita a Londra in compagnia del padre. La sua ammirazione si estendeva anche a tutti gli attori italiani in voga sulle scene europee, che …

THE LONG ROAD TO THE INTERNATIONAL RECOGNITION OF ECONOMIC AND SOCIAL RIGHTS: THE RIGHT TO AN ADEQUATE STANDARD OF LIVING

2018

A long road was necessary for economic and social rights to be internationally recognized. In fact, it was only after the Second World War that the protection of human rights, including economic and social rights, became one of the aims of the United Nations. Despite that, this legal protection was by no means made without controversies, especially when it comes to economic and social rights. The fact that most of the articles of the Universal Declaration of Human Rights refer to civil and political rights corroborates these difficulties. Only articles 22 through 27 protected economic and social rights. The objective of this article is to shed some light into this process, as the Universal …

Conferma della riproduzione del Cuculo dal ciuffo Clamator glandarius in Sicilia

2008

Estudio de la prevalencia de incontinencia fecal y alteración de la calidad de vida referida a la misma en pacientes con enfermedad inflamatoria inte…

2017

RESUMEN Objetivos: Conocer la prevalencia de la incontinencia fecal (IF) en los pacientes con Enfermedad Inflamatoria Intestinal Crónica (EIIC) y analizar su impacto en la calidad de vida. Métodos: Estudio prospectivo aleatorizado, descriptivo y analítico en 726 pacientes con EIIC (Enfermedad de Crohn (EC) y Colitis Ulcerosa (CU)) pertenecientes al departamento de salud del Hospital Clínico de Valencia. Se excluyen pacientes<18 años, pacientes con colitis indeterminadas, portadores de colostomías, ileostomías, reservorios o deterioro cognitivo. Se recogen variables demográficas, características fenotípicas de su EIIC, antecedentes personales y actividad de la EIIC. Se evalúa la calidad de v…

From Europe to Africa and vice versa: evidence for multiple intercontinental dispersal in ribbed salamanders (Genus Pleurodeles)

2004

Aim  The intricate puzzle-like geography of the western Mediterranean is a product of long-term tectonic and orogenic events, supplemented by repeated climatic oscillations since the Pliocene. It offers numerous vicariance events that may be invoked to explain speciation in amphibians. We test for plausibility of two mutually exclusive Iberian–African vicariance hypotheses to explain the basal split within newts of the genus Pleurodeles: (1) the disconnection of the Betic arch c. 14 Ma and (2) the end of the Messinian salinity crisis 5.33 Ma. Location  Specimens of P. waltl and P. poireti were sampled from 32 populations in Portugal, Spain, Morocco, Algeria and Tunisia. Methods  Parts of th…

A molecular phylogeny of ‘true’ salamanders (family Salamandridae) and the evolution of terrestriality of reproductive modes

2009

Key innovations enable species to conquer new habitats. Within the family Salamandridae, particular adaptations to terrestrial life, such as the anatomy and physiology of the feeding apparatus, courtship behaviour and in some cases viviparity, allowed the ‘true’salamanders (genera Chioglossa, Mertensiella, Salamandra) to shift from a semi-aquatic to a more terrestrial life cycle. We sequenced 423 base pairs of the 16S RNA gene of the mitochondrial DNA for all species of the ‘true’salamanders. Based on the resulting phylogeny we discuss the evolution of terrestrial reproductive modes within this species group. We especially tested two hypotheses of monophyletic origin of specific adaptations…