Search results for "Lama"

Merkittävä liikunnanopettajakoulutuksen kehittäjä ja liikuntakasvatuksen tutkija

2023

Liikuntapedagogiikan professori Risto Telama menehtyi 86-vuotiaana 14. marraskuuta 2022 Jyväskylässä. nonPeerReviewed

In memoriam: Risto Telama : ensimmäinen Suomessa väitellyt liikuntatieteiden tohtori

2023

Maaseutuyhteisön kriisi : 1930-luvun pula ja pakkohuutokaupat paikallisena ilmiönä Kalajokilaaksossa

2005

Maijala on väitöskirjassaan tutkinut 1930-luvun talouspulan vaikutusta suomalaiseen maaseutuyhteisöön sekä yhteisön selviytymistä kohtaamastaan taloudellisesta kriisistä. Kriisin syntyyn vaikutti vanhakantaisen maaseutuyhteisön perinteisten toimintamallien yhteentörmäys modernisoituvan yhteiskunnan kanssa. Murros johti talonpoikasen väestön monimuotoiseen vastarintaan, ja kriisistä selviytyminen vaati ennen kaikkea kykyä sopeutua muutokseen. Vaikka Maijalan tutkimuksen kohteena on Kalajokilaakso ja siellä erityisesti Reisjärvi, väitöskirjan tarkoituksena ei ole tutkia yksittäistä kohdetta. Tutkimuksen kohteena on prosessi, jonka tutkiminen Kalajokilaaksossa oli mahdollista. This study descr…

Matkailutilan sukupolvenvaihdos talonpoikaisten arvojen ohjaamana prosessina

2005

he aim of this multiple case study that is based on phenomenological hermeneutics is to increase our understanding of family entrepreneurship in general and succession in particular from the viewpoint of traditional values. The study is exploratory and its focus is on small family firms engaged in tourism. The research material includes narrative life stories of predecessors and successors of seven tourism farms.The main research question of the study is how traditional values affect family entrepreneurship and the succession process in small family farms engaged in tourism. The answer is pursued by exploring how they became engaged in tourism, what kind of a family entrepreneurship phenome…

Estudio de la respuesta antiinflamatoria y antifibrótica de Rilpivirina en células hepáticas no parenquimales

2022

Hoy en día, la infección por el VIH-1 ha pasado de considerarse una enfermedad mortal a convertirse en una condición crónica manejable. Sin embargo, con un tratamiento de por vida y una esperanza de vida cercana a la de la población general, los pacientes con VIH-1 se enfrentan a un mayor riesgo de desarrollar otras patologías crónicas como la enfermedad de hígado graso no alcohólico (NAFLD). Entre los fármacos antirretrovirales empleados para la infección por VIH-1, la Rilpivirina (RPV) está considerada como segura para el hígado y, además, podría ejercer un efecto hepatoprotector. En la presente tesis doctoral se estudió la respuesta antiinflamatoria y antifibrótica inducida por RPV en la…

The effect of tiotropium/olodaterol versus tiotropium on COPD exacerbation rates in patients with/without frequent exacerbation history

2019

Background: Patients with COPD with a history of frequent exacerbations are at increased risk of future exacerbations. There are limited data as to whether combining LAMA/LABA reduces exacerbation risk in all patients. We investigated whether tiotropium/olodaterol (T/O) reduced exacerbation rate versus tiotropium (tio) in patients with a range of exacerbation histories. Methods: TONADO 1+2 (NCT01431274/NCT01431287) and DYNAGITO (NCT02296138) were 52-week, parallel-group, randomised, double-blind, Phase III trials in COPD patients with FEV1 Results: There was a lower rate of moderate/severe exacerbations with T/O (0.68 per patient-year) than tio (0.77 per patient-year) (rate ratio [RR] vs ti…

Pharmacotherapy of COPD in Central and Eastern Europe - The POPE study

2016

Introduction: In Central and Eastern Europe (CEE) the burden of chronic obstructive pulmonary disease (COPD) is high. It remains unknown whether patients are treated in line with GOLD recommendations or according to their phenotypes. Our aim was to analyze the treatment patterns of COPD in CEE. Methods: In the frame of the POPE study (ClinicalTrials.gov - NCT02119494) data including pharmacotherapy were collected in patients with stable COPD across 11 CEE countries. Results: 3366 patients (66±9 yrs, 70% male, FEV 1 53±18%) participated in the study. In all GOLD categories, the most widely used medications were long-acting beta-2 agonists (LABA), followed by long-acting antimuscarinic agents…

Triple therapy de-escalation to dual bronchodilation in COPD patients: Baseline data from the DACCORD cohort

2020

Background: GOLD recommends triple therapy only in COPD patients with frequent exacerbations despite long-acting bronchodilators who exhibit a high blood eosinophil level (≥300/μL). Indication for ICS containing therapy should be reassessed regularly. Methods: The German real life study DACCORD included COPD patients who had received free triple therapy for ≥ 6 months prior to study entry. At baseline, patients were switched to LABA+LAMA fixed-dose combination (FDC) or maintained triple therapy upon discretion of the treating physician. Here, we compare baseline data of the 2 groups. Results: 1182 patients were recruited into DACCORD of which 30.7% were moved to LABA+LAMA FDC. Patients in t…

Benefits of tiotropium/olodaterol compared with tiotropium in patients receiving COPD LAMA at baseline: pooled analysis of 4 clinical trials

2020

Management of patients with Intestinal Bowel Disease and COVID-19: A review of current evidence and future perspectives

2022

La pandemia por COVID-19 ha supuesto un reto para los países y sus profesionales sanitarios. La entrada viral en el hospedador a través del receptor ACE-2 y una activación excesiva del sistema inmunológico son claves para comprender tanto la incidencia como la gravedad de la enfermedad. La enfermedad inflamatoria intestinal (EII) representa una condición especial asociada con una respuesta descontrolada del sistema inmunológico a agentes externos. Los tratamientos para la EII se han asociado con un mayor riesgo de infecciones bacterianas y virales. Esto ha planteado la cuestión de una posible mayor incidencia y gravedad de la infección por COVID-19 en pacientes con EII. A lo largo de este a…