Search results for "Lament"

Activation of cGMP-dependent Protein Kinase Iβ Inhibits Interleukin 2 Release and Proliferation of T Cell Receptor-stimulated Human Peripheral T Cells

2000

Several major functions of type I cGMP-dependent protein kinase (cGK I) have been established in smooth muscle cells, platelets, endothelial cells, and cardiac myocytes. Here we demonstrate that cGK Ibeta is endogenously expressed in freshly purified human peripheral blood T lymphocytes and inhibits their proliferation and interleukin 2 release. Incubation of human T cells with the NO donor, sodium nitroprusside, or the membrane-permeant cGMP analogs PET-cGMP and 8-pCPT-cGMP, activated cGK I and produced (i) a distinct pattern of phosphorylation of vasodilator-stimulated phosphoprotein, (ii) stimulation of the mitogen-activated protein kinases ERK1/2 and p38 kinase, and, upon anti-CD3 stimu…

Reciprocal regulation of human platelet function by endogenous prostanoids and through multiple prostanoid receptors

2014

Platelets are permanently exposed to a variety of prostanoids formed by blood cells or the vessel wall. The two major prostanoids, prostacyclin and thromboxane act through well established pathways mediated by their respective G-protein coupled receptors inhibiting or promoting platelet aggregation accordingly. Yet the role of other prostanoids and prostanoid receptors for platelet function regulation has not been thoroughly investigated. We aimed at a comprehensive analysis of prostanoid effects on platelets, the receptors and pathways involved and functional consequences. We analyzed cAMP formation and phosphorylation of proteins pivotal to platelet function as well as functional platelet…

Shortstop Recruits EB1/APC1 and Promotes Microtubule Assembly at the Muscle-Tendon Junction

2003

Abstract Background: Shot (previously named Kakapo), is a Drosophila Plakin family member containing both Actin binding and microtubule binding domains. In Drosophila , it is required for a wide range of processes, including axon extension, dendrite formation, axonal terminal arborization at the neuromuscular junction, tendon cell development, and adhesion of wing epithelium. Results: To address how Shot exerts its activity at the molecular level, we investigated the molecular interactions of Shot with candidate proteins in mature larval tendon cells. We show that Shot colocalizes with EB1/APC1 and with a compact microtubule array extending between the muscle-tendon junction and the cuticle…

Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine.

1994

The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129C, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole-cell pertussis component-diphtheria-tetanus vaccine. Four hundred eighty infants were enrolled into this prospective, multicenter, double-blind study. Each infant was randomly given three doses of one of the two vaccines at 2, 4, and 6 months of age. Both local and systemic adverse reactions, reported within 48 hours and 7 days of each injection, were less frequent after the acellular vaccine than after the whole-cell vaccine. The enzyme-lin…

Conflicting conceptualisations of ‘democracy’ in the German Bundestag during the anti-nuclear demonstrations, 1995-2001

2018

A vigorous anti-nuclear movement emerged in Germany in the mid 1990s, when spent nuclear fuel elements began to be transported to the interim storage facility in Gorleben, Lower Saxony. Resistance to nuclear transportation continued to grow in strength throughout the 1990s. The protests expressed people’s distrust and lack of confidence in political institutions and decision-making processes. In the German Bundestag, these events relating to Gorleben caused significant political struggles over the principles and meanings of German democracy. Parliamentarians voiced competing counterarguments about the legitimacy of these demonstrations, on the one hand, and the legitimacy of the nuclear ene…

Parliamentary Democracy Versus Direct Democracy? : Challenging Liberal, Representative Democracy in the German Bundestag During the Anti-nuclear Demo…

2019

In German politics, concepts of parliamentarism and the relationship between parliamentarism and democracy have evolved since the nineteenth century. Politicians, citizens and scholars have regularly redefined and challenged conceptions of parliament’s task of representation, public debate and legitimate decision-making in different historical circumstances. One such crucial phase in re-evaluating and redefining conceptions of democracy in Germany was the second half of the 1990s, when a vigorous anti-nuclear movement arose. In the German federal parliament, members had to explain their understandings of German democracy. The tradition of liberal, representative democracy was in a conflict …

Bíblia. Profetes. Llatí. Seleccions

Ms Títol donat pel catalogador Col·lació: Vitel·la, f. i (pergamí actual) + iii (paper) + 208 + ii (paper) + i (pergamí actual) ; numeració moderna a llapis Composició: Text de la Bíblia i dels comentaris en dues i tres columnes i a línia tirada amb nombre de línies variable. Pautat amb mina de plom Escriptura: Gòtica textual cal·ligràfica Decoració: Caplletres decorades, calderons i titolets alternant tintes de color blau i vermell Enquadernació: Restaurada, plateresca, pell verda sobre fusta, amb ferros freds. En la coberta anterior, amb ferros daurats, l'escut d'armes del duc de Calàbria entre florons; hi manquen els fermalls originals. Cantells acolorits en vermell. Al llom, amb ferros …

Bíblia. Llatí. Seleccions

Ms Títol donat pel catalogador Col·lació: Vitel·la, f. iii (paper) + 105 (en blanc els ff. 3-4, 60 i 105v) + iii (paper) ; numeració moderna a llapis Composició: Text de la Bíblia i dels comentaris en dues o tres columnes, amb nombre de línies variable i alguns fulls a línea tirada. Pautat amb mina de plom Escriptura: Gòtica textual cal·ligràfica Decoració: Caplletres decorades, calderons, titolets i majúscules alternant tintes de color blau i vermell Enquadernació: Original, pell marró sobre fusta, de rodes amb ferros freds. En la coberta anterior, amb ferros daurats, l'escut d'armes del duc de Calàbria entre florons; restes dels fermalls originals. Cantells acolorits en porpra. Al llom, a…

Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.

2014

Background and objective: Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy.Materials and methods: We enrolled 118 patients undergoing elective or acute percutaneous coronary intervention (PCI) with drug eluting stent (DES). Platelet reactivity index (PRI) was measured using the vasodilator-stimulated phosphoprotein (VASP) index and a cut-off value of ≥60% was defined as hyporesponsiveness. Polymorphism of two cytochromes (CYP2C19, CYP2C9) and gene ABCB1 were determined. …

Reales Cedulas de ereccion, y Ordenanzas de los tres Cuerpos de Comercio, que residen en la Ciudad y Reyno de Valencia

1766

Escut reial al començament de la Cèdula que segueix a la port., p. [3 Grav. a la p. 1: "Valencia Año 1754", "Fecit Emmanuel Monfort Regiae S. Ferdinandi Academicus Escut. calc. de la Reial Junta Particular de Comerç i Consolat de València "Ml. Monfort fecit Val." Caplletres historiades Sign. : [ ]1, *₁-*₃2, A-T2 Port. a dues tintes amb vinyeta Reclams