Search results for "Lament"
showing 10 items of 895 documents
Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis
2010
Filamin A (FLNA) is an integrator of cell mechanics and signaling. The spreading and migration observed in FLNA sufficient A7 melanoma cells but not in the parental FLNA deficient M2 cells have been attributed to FLNA. In A7 and M2 cells, the normal prion (PrP) exists as pro-PrP, retaining its glycosylphosphatidyl-inositol (GPI) anchor peptide signal sequence (GPI-PSS). The GPI-PSS of PrP has a FLNA binding motif and binds FLNA. Reducing PrP expression in A7 cells alters the spatial distribution of FLNA and organization of actin and diminishes cell spreading and migration. Integrin β1 also binds FLNA. In A7 cells, FLNA, PrP, and integrin β1 exist as two independent, yet functionally linked,…
Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with xenogeneic sponge molecule(s)
2000
Porifera (sponges) constitute the lowest metazoan phylum, Experiments examined whether sponges can recognize self/nonself molecules. Cells from the marine sponge Suberites domuncula were incubated with membranes from either S. domuncula or another marine sponge, Geodia cydonium, as well as with recombinant alpha-integrin from G. cydonium. The cells responded immediately with a rise of intracellular Ca2+ ([Ca-i(2+)]) if they were treated with membranes from G. cydonium but not after treatment by those from S. domuncula. This change of [Ca-i(2+)] was also recorded with G. cydonium alpha-integrin. In parallel, the expression of two genes was strongly upregulated; one codes for a cytokine-relat…
Microtubules and intermediate filaments of herpes simplex virus infected cells.
1987
The fate of microtubules and of vimentin or keratin containing intermediate filaments during infection with fusion or rounding producing strains of herpes simplex virus (HSV) was investigated. Microtubules polymerize early after fusion of cells. However, they do not reconstitute 6–7 hours post infection (p.i.) after release of a colcemid block. Keratin and vimentin are maintained around the original nucleus still inside of recruited cells in the polykaryocyte. Cells of fibroblastic and epithelial origin fuse. Inside of polykaryocytes keratin or vimentin containing fibers seem to polymerize. Keratin is to be found in invaginations in the nuclei surrounded by the inner layer of the nuclear me…
Interna corporis, immunità parlamentare e status dei deputati europei
2002
Il contributo prende in esame la questione dello status dei parlamentari europei alla luce della giurisprudenza della corte di Giustizia
Evolving Conceptualisations of Internationalism in the UK Parliament : Collocation Analyses from the League to Brexit
2020
This chapter explores a historical distant reading strategy of British Parliamentary discourse. It uses historical collocation analyses of ‘internationalism’ and the ‘international’ in the British Hansard Corpus and a selection of Commons and Lords debates concerning British membership in international organisations as it relates to the League of Nations, United Nations, Council of Europe, EEC and Brexit. The collocates that were deemed to be politically significant are grouped in 13 loose semantic fields. This macro-level analysis of long-term trends of discourse is supplemented with an analysis of the said key debates in their historical contexts, including comparisons between the two Hou…
Intracellular trafficking of endogenous fibroblast growth factor‐2
2008
We have previously reported how the release of fibroblast growth factor-2 (FGF-2) is mediated by shed vesicles. In the present study, we address the question of how newly synthesized FGF-2 is targeted to the budding vesicles. Considering that in vitro cultured Sk-Hep1 hepatocarcinoma cells release FGF-2 and shed membrane vesicles only when cultured in the presence of serum, we added serum to starved cells and monitored intracellular movements of the growth factor. FGF-2 was targeted both to the cell periphery and to the nucleus and nucleolus. Movements toward the cell periphery were not influenced by drugs affecting microtubules, but were inhibited by cytocalasin B. Involvement of actin in …
Isolamento sismico di serbatoi di impianti chimici a Priolo Gargallo (SR)
2013
I serbatoi di stoccaggio degli impianti petrolchimici costituiscono una seria minaccia alla salvaguardia dell’ambiente, a causa delle conseguenze disastrose derivanti da un loro collasso, come messo in luce dai recenti eventi catastrofici. Pertanto, l’ENEA ed il GLIS hanno intrapreso un’intensa attività di ricerca e di informazione per sensibilizzare l’opinione pubblica su tali importanti pericoli. Tra le cause più frequenti di collasso si citano le azioni sismiche, particolarmente rilevanti in zone prossime a faglie attive, come risulta quella di Priolo Gargallo, in provincia di Siracusa, già sede di sismi distruttivi. I danni sono stati spesso ingigantiti dagli incendi sviluppatisi in seg…
Evaluation of innovative thermal insulation systems for a sustainable envelope
2017
La memoria presenta i risultati ottenuti su sistemi di isolamento termico per l’involucro edilizio. Si presentano i risultati ottenuti tramite simulazioni informatiche che hanno consentito di verificare e ottimizzare la trasmissione del calore attraverso un sistema sottovuoto in vetro per le facciate trasparenti. Inoltre la possibilità offerta dal riciclo del materiale di scarto della potatura dell’Opunthia Ficus Indica (fichi d’india) che,opportunamente trattato ha permesso di ottenere un materiale isolante (Brevetto n. 1402131), in forma di pannello o in grani sfusi, (valori di coibenza termica 0.0710.057 W/mK). The paper presents the results of the research on thermal insulation systems…
Lascia che Caino scambi una parola. La Corte europea censura l’Ucraina perché inibisce l’interazione umana fra condannati all’ergastolo
2022
Continua il rimodellamento in chiave incrementale dei diritti dei detenuti da parte della Corte europea dei diritti dell’uomo. Con la sentenza Karpenko c. Ucraina è stata riconosciuta una violazione degli artt. 3 e 13 CEDU, in riferimento al regime penitenziario di isolamento che ha inibito a un condannato all’ergastolo di parlare con altri soggetti ristretti.
Gozos al descendimiento de Cristo de la cruz, por Joseph y Nicodemus, que pidieron licencia, á Pilatos á fin de darle sepultura conforme se hace menc…
El full orlat Grav. xil. enmarcat del davallament, flanquejat per gerros amb flors Text del goig a tres col. separades per filets