Search results for "Lament"
showing 10 items of 895 documents
Coupling Proteomics and Fermentation Technology for the Improvement of Bioactive Molecule Production Yield in Actinomycetes
2013
Copyright: © 2013 Gallo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Most bioactive molecules (like anticancers, antitumors, antibiotics, immunosuppressants, insecticidals, antivirals, herbicidals, antifungals) with valuable industrial and market value are naturally produced by actinomycetes [1-4], Gram-positive filamentous bacteria widespread in both terrestrial and aquatic environments [5,6]. Out of thousands of bioactive molecules, also known as secondary metabolites since they are not essential for…
0393: Impact of miR-378* and its target desmin intermediate filament on mitochondria distribution in cardiomyocytes
2014
Background MiR-378 and miR-378* microRNAs are derived from an intron of the PGC-1β gene, a regulator of mitochondrial biogenesis. Their expression is either repressed or increased during heart failure depending on the model. Through proteomics approaches, we previously identified new targets of these miRs in H9c2 fetal cardiomyoblasts, among which lactate dehydrogenase for miR-378 and key cytoskeletal proteins for miR-378*. Aims To better assess its role in energy metabolism and differentiation; we overexpressed miR-378 and miR-378* in primary neonate rat cardiomyocytes (NRC) that are more differentiated and less proliferative than H9c2 cardiomyoblasts. Results We identified desmin as a new…
A Controlled Trial of Two Acellular Vaccines and One Whole-Cell Vaccine against Pertussis
1996
Background Concern about both safety and efficacy has made the use of whole-cell pertussis vaccines controversial. In some European countries, including Italy, the rate of vaccination against pertussis is low. Methods We conducted a double-blind trial in Italy in which infants were randomly assigned to vaccination at two, four, and six months of age with an acellular pertussis vaccine together with diphtheria and tetanus toxoids (DTP); a DTP vaccine containing whole-cell pertussis (manufactured by Connaught Laboratories); or diphtheria and tetanus toxoids without pertussis (DT). The acellular DTP vaccine was either one containing filamentous hemagglutinin, pertactin, and pertussis toxin ina…
Agreements regarding the property relations of transnational couples and their effects under the application of the twin regulations
2021
It is a true and verifiable fact that the family institution has evolved over recent decades in Europe and throughout the world, but not uniformly or at the same time. This is because it is influenced by social and cultural connotations specific to each State. All of which are respected under EU Regulations 2016/1103 and 2016/1104. This work analyses the Twins Regulations, that gives the couples the possibility of choosing the jurisdiction (art. 7) and applicable legal system underpinning the property consequences of the marriage and registered partnerships (art. 22.1). However, we try to show you these rules absolute freedom of choice is not granted to the parties, because this freedom is …
La mejora de la calidad normativa Estudio comparado de procedimientos para la elaboración de normas e instrumentos para la mejora y evaluación de su …
2020
La mejora de la calidad normativa y su posterior evaluación forman parte de las preocupaciones actuales de nuestro Derecho público. No obstante, hasta fechas muy recientes, principalmente por influencia de modelos anglosajones y, muy particularmente, de la Unión Europea, no se han ido introduciendo medidas en este ámbito, y su desarrollo hasta hoy tampoco ha sido demasiado satisfactorio. El presente estudio analiza los problemas y las ineficiencias del modelo español para la mejora de la calidad normativa y trata de sistematizar una serie de propuestas a través del diseño de un nuevo modelo de producción y evaluación normativa. Para ello, no solo se analiza críticamente el desarrollo legisl…
Cambiamenti climatici, selvicoltura e popolamenti a rischio
2014
Il contributo prende in esame alcune criticità dei popolamenti al margine dell'areale di diffusione, in quanto soggetti a pressioni ecologiche a seguito del cambiamento climatico in atto. Si esaminano casi di studio e si indicano alcuni indirizzi colturali volti a ridurre gli stress e le criticità in atto
Il capitale degli intermediari bancari tra teoria e regolamentazione
2009
Le proprietà nutrizionali e salutistiche del formaggio in funzione della stagione di pascolamento
2022
Il consumo alimentare si è notevolmente modificato negli ultimi anni. L’alimento, oltre a rappresentare una fonte di nutrienti, è diventato anche espressione dello stile di vita ed un mezzo di interazione e distinzione tra le persone. Il consumatore moderno, in risposta ai modelli alimentari che nei paesi industrializzati hanno generato gravi problemi di salute (obesità, malattie cardiovascolari, tumori), tende ad essere più informato, critico ed esigente sotto il profilo salutistico. Inoltre, cresce nel consumatore l'interesse per il cibo sostenibile proveniente da sistemi che, contribuendo alla mitigazione delle emissioni di CO2 e limitando lo sfruttamento delle risorse naturali, producon…
Popolarismo e costituzionalismo in Filippo Meda.Lettere a Giuseppe Toniolo 1890-1917
2007
Il volume tratta della figura e dell'opera di Filippo Meda, esponente del movimento cattolico italiano tra la fine del XIX secolo e il primo trentennio del XX. Alla luce di un epistolario intercorso tra Meda e Toniolo si ripercorre il dramma di quei cattolici italiani nel tentativo di coniugare, a seguito della caduta del potere temporale del papa, il desiderio di essere cittadini attivi di una Patria riscattata e la volontà di rimanere fedeli ubbidienti alla Chiesa romana.
Silintaphin-1 - interaction with silicatein during structure-guiding bio-silica formation
2011
Silicateins are unique enzymes of sponges (phylum Porifera) that template and catalyze the polymerization of nanoscale silicate to siliceous skeletal elements. These multifunctional spicules are often elaborately shaped, with complex symmetries. They carry an axial proteinaceous filament, consisting of silicatein and the scaffold protein silintaphin-1, which guides silica deposition and subsequent spicular morphogenesis. In vivo, the synthesis of the axial filament very likely proceeds in three steps: (a) assembly of silicatein monomers to form one pentamer; (b) assembly of pentamers to form fractal-like structures; and finally (c) assembly of fractal-like structures to form filaments. The …