Search results for "Lamina propria"

showing 3 items of 43 documents

Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

2008

Background & Aims Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-β signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-β signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg-mediated suppression. In this study, we have investigated whether IBD mucosal CD4+ T cells are resistant to Tregs and whether Smad7 is involved in this process. Methods IBD lamina propria mononuclear cells …

antisense oligonucleotideCD4-Positive T-LymphocytesAdoptive cell transferT-Lymphocytesanimal cellCell CommunicationInbred C57BLT-Lymphocytes RegulatoryTransgenicMiceregulatory T lymphocyteCrohn DiseaseTransforming Growth Factor betamononuclear cellRAG1 proteinIntestinal MucosaenteritisCells CulturedMice KnockoutSettore MED/12 - GastroenterologiaCulturedintegumentary systemmedicine.diagnostic_testarticleGastroenterologyInterleukinhemic and immune systemsT helper cellColitisRegulatoryUp-Regulationmedicine.anatomical_structurepriority journalgamma interferonSignal TransductionRegulatory T cellColonCellsKnockoutanimal experimentinterleukin 6chemical and pharmacologic phenomenaMice TransgenicBiologyinterleukin 2Recombination-activating geneFlow cytometryProinflammatory cytokineSmad7 ProteinmedicineAnimalsHumanscontrolled studyhumanlamina propriamouseCell ProliferationHomeodomain ProteinsCD4+ T lymphocytenonhumanHepatologyAnimalflow cytometryhuman cellanimal cell culturetransgenic mouseMice Inbred C57BLDisease Models Animalantisense oligonucleotide; gamma interferon; interleukin 17; interleukin 2; interleukin 6; RAG1 protein; Smad7 protein; animal cell; animal cell culture; animal experiment; article; CD4+ T lymphocyte; cell proliferation; colitis; controlled study; enteritis; flow cytometry; human; human cell; knockout mouse; lamina propria; mononuclear cell; mouse; nonhuman; priority journal; regulatory T lymphocyte; transgenic mouse; Animals; CD4-Positive T-Lymphocytes; Cell Communication; Cell Proliferation; Cells Cultured; Colitis; Colon; Crohn Disease; Disease Models Animal; Homeodomain Proteins; Humans; Intestinal Mucosa; Mice; Mice Inbred C57BL; Mice Knockout; Mice Transgenic; Signal Transduction; Smad7 Protein; T-Lymphocytes Regulatory; Transforming Growth Factor beta; Up-RegulationDisease ModelsImmunologyinterleukin 17knockout mouseTransforming growth factorGastroenterology
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Ischemia and post-ischemic regeneration of the small intestinal mucosa

1978

After ligation of the vascular arcades of the upper jejunum in rats, the ischemic damage to the intestinal mucosa and its regenerative behavior after ischemia lasting 120 minutes were investigated with histological and enzyme-histochemical methods. During the ischemic injury of the jejunal mucosa, there is rejection of hydropically swollen epithelial cells into the intestinal lumen advancing from the tip to the base of the villi without a previously detectable loss of activity of the enzymes investigated. At the end of ischemia lasting 120 minutes, there is complete destruction of the villi as well as the upper portions of the crypts. After rapid re-epithelialization of the mucosal surface …

chemistry.chemical_classificationLamina propriaPathologymedicine.medical_specialtyHistologyCryptIschemiaCell BiologyGeneral MedicineBiologymedicine.diseasedigestive systemEpitheliumJejunummedicine.anatomical_structureEnzymechemistryIntestinal mucosamedicineLigationActa Histochemica
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Honey Bee Pollen in Meagre (Argyrosomus regius) Juvenile Diets: Effects on Growth, Diet Digestibility, Intestinal Traits, and Biochemical Markers Rel…

2020

This research aimed to evaluate the effects of the inclusion of honey bee pollen (HBP) in meagre (Argyrosoumus regius) juveniles&rsquo

total serum proteingrowth trialtrace elementsArgyrosomus regiusmedicine.disease_causemeagre honey bee pollen growth trial digestibility trial TNF-α HSP70 intestinal immunohistochemistry toxic elements trace elements total serum proteinArticleintestinal immunohistochemistry03 medical and health sciencesAnimal sciencePredatory fishIntestinal mucosaSettore AGR/20 - ZoocolturePollenlcsh:Zoologymedicinelcsh:QL1-991toxic elementKeywords: meagreDigestibility trial; Growth trial; Honey bee pollen; HSP70; Intestinal immunohistochemistry; Meagre; TNF-α; Total serum protein; Toxic elements; Trace elementsHSP70030304 developmental biology2. Zero hungertoxic elements0303 health sciencesLamina proprialcsh:Veterinary medicineGeneral Veterinarybiologydigestibility trialfood and beveragestrace elementHistology04 agricultural and veterinary sciencesHoney beebiology.organism_classificationmeagre3. Good healthmedicine.anatomical_structureBee pollenTNF-α040102 fisherieslcsh:SF600-11000401 agriculture forestry and fisheriesAnimal Science and Zoologyhoney bee pollenAnimals
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