Search results for "Lantibiotics"

showing 5 items of 5 documents

LAPTOP: Lantibiotic production, Technology, optimization and improved process

2013

Actinomycetes Lantibiotics Production
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Proteomic investigations to unravel molecular physiology of the lantibiotic producer Microbispora sp. ATCC‐PTA‐5024

2013

Actinomycetes Lantibiotics Proteomics 2D-DIGE Mass spectrometry
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Regulatory and metabolic proteins differentially expressed during NAI-107 production in Microbispora sp. ATCC-PTA 5024

2014

Microbispora sp. ATCC-PTA 5024proteomicsNAI-107NAI-107 LantibioticsMicrobispora sp. ATCC-PTA 5024 proteomicsLantibiotics
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Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107.

2014

ABSTRACT We report the draft genome sequence of Microbispora sp. strain ATCC-PTA-5024, a soil isolate that produces NAI-107, a new lantibiotic with the potential to treat life-threatening infections caused by multidrug-resistant Gram-positive pathogens. The draft genome of strain Microbispora sp. ATCC-PTA-5024 consists of 8,543,819 bp, with a 71.2% G+C content and 7,860 protein-coding genes.

Strain atccWhole genome sequencingStrain (chemistry)Microbispora sp.GeneticsProkaryotesLantibioticsBiologyMolecular BiologyGenomeGeneC contentMicrobiologyGenome announcements
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Inorganic phosphate is a trigger factor for Microbispora sp. ATCC-PTA-5024 growth and NAI-107 production

2014

Background NAI-107, produced by the actinomycete Microbispora sp. ATCC-PTA-5024, is a promising lantibiotic active against Gram-positive bacteria and currently in late preclinical-phase. Lantibiotics (lanthionine-containing antibiotics) are ribosomally synthesized and post-translationally modified peptides (RiPPs), encoded by structural genes as precursor peptides. The biosynthesis of biologically active compounds is developmentally controlled and it depends upon a variety of environmental stimuli and conditions. Inorganic phosphate (Pi) usually negatively regulates biologically-active molecule production in Actinomycetes, while it has been reported to have a positive control on lantibiotic…

food.ingredientPhosphateBioengineeringBiologyApplied Microbiology and BiotechnologyPhosphatesMicrobiologychemistry.chemical_compoundfoodBacteriocinsBiosynthesisPolyphosphateHumansRibosomal Post-translationally modified Peptides (RiPPs)2. Zero hungerPhoP-PhoRResearchStructural geneBiological activityLantibioticsbiology.organism_classificationActinobacteriaRibosomal Post-translationally modified Peptides (RiPPs) Phosphate PhoP-PhoR PolyphosphateChemically defined mediumRegulonchemistryBiochemistryMicrobisporaBacteriaBiotechnology
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