Search results for "Large-Scale"
showing 10 items of 83 documents
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
2011
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through w…
Optical Probing (EOFM/TRI): A large set of complementary applications for ultimate VLSI
2013
International audience; Electro Optical Techniques (EOFM: Electro Optical Frequency Mapping and EOP: Electro Optical Probing) and Dynamic Light Emission Techniques (TRE: Time Resolved Emission and TRI: Time Resolved Imaging) are dynamic optical probing techniques widely used at IC level for design debug and defect localization purpose. They can pinpoint the origin of timing issue or logic fault in up to date CMOS devices. Each technique has its advantages and its drawbacks allowing a common set of applications and more specific ones. We have been involved in the development of the most advanced techniques related to EOFM and TRI on various devices (down to 28nm technology). What we can expe…
Handling precedence constraints in scheduling problems by the sequence pair representation
2015
In this paper, we show that sequence pair (SP) representation, primarily applied to the rectangle packing problems appearing in the VLSI industry, can be a solution representation of precedence constrained scheduling. We present three interpretations of sequence pair, which differ in complexity of schedule evaluation and size of a corresponding solution space. For each interpretation we construct an incremental precedence constrained SP neighborhood evaluation algorithm, computing feasibility of each solution in the insert neighborhood in an amortized constant time per examined solution, and prove the connectivity property of the considered neighborhoods. To compare proposed interpretations…
VET workers’ problem-solving skills in technology-rich environments: European approach
2014
International journal for research in vocational education and training 1 (2014) 1, S. 57-80
Operational experience with a large detector system using silicon strip detectors with double sided readout
1992
Abstract A large system of silicon strip detectors with double sided readout has been successfully commissioned over the course of the last year at the e + e − collider LEP. The readout of this 73 728 channel system is performed with custom designed VLSI charge sensitive amplifier chips (CAMEX64A). An overall point resolution of 12 μm on both sides has been acheived for the complete system. The most important difficulties during the run were beam losses into the detector, and a chemical agent deposited onto the electronics; however, the damage from these sources was understood and brought under control. This and other results of the 1991 data-taking run are described with special emphasis o…
Do we have any hope of detecting scattering between dark energy and baryons through cosmology?
2020
We consider the possibility that dark energy and baryons might scatter off each other. The type of interaction we consider leads to a pure momentum exchange, and does not affect the background evolution of the expansion history. We parametrize this interaction in an effective way at the level of Boltzmann equations. We compute the effect of dark energy-baryon scattering on cosmological observables, focusing on the Cosmic Microwave Background (CMB) temperature anisotropy power spectrum and the matter power spectrum. Surprisingly, we find that even huge dark energy-baryon cross-sections $\sigma_{xb} \sim {\cal O}({\rm b})$, which are generically excluded by non-cosmological probes such as col…
On the estimation and detection of the Rees Sciama effect
2017
Maps of the Rees–Sciama (RS) effect are simulated using the parallel N-body code, hydra, and a run-time ray-tracing procedure. A method designed for the analysis of small, square cosmic microwave background (CMB) maps is applied to our RS maps. Each of these techniques has been tested and successfully applied in previous papers. Within a range of angular scales, our estimate of the RS angular power spectrum due to variations in the peculiar gravitational potential on scales smaller than 42/h megaparsecs is shown to be robust. An exhaustive study of the redshifts and spatial scales relevant for the production of RS anisotropy is developed for the first time. Results from this study demonstra…
Point field models for the galaxy point pattern modelling the singularity of the two-point correlation function
2002
There is empirical evidence that the two-point correlation function of the galaxy distribution follows, for small scales, reasonably well a power-law expression $\xi(r)\propto r^{-\gamma}$ with $\gamma$ between 1.5 and 1.9. Nevertheless, most of the point field models suggested in the literature do not have this property. This paper presents a new class of models, which is produced by modifying point fields commonly used in cosmology to mimic the galaxy distribution, but where $\gamma=2$ is too large. The points are independently and randomly shifted, leading to the desired reduction of the value of $\gamma$.
Multiscaling Properties of Large-Scale Structure in the Universe
1995
The large-scale distribution of galaxies and galaxy clusters in the universe can be described in the mathematical language of multifractal sets. A particularly significant aspect of this description is that it furnishes a natural explanation for the observed differences in clustering properties of objects of different density in terms of multiscaling, the generic consequence of the application of a local density threshold to a multifractal set. The multiscaling hypothesis suggests ways of improving upon the traditional statistical measures of clustering pattern (correlation functions) and exploring further the connection between clustering pattern and dynamics.
Full Wave Solution for Intel CPU With a Heat Sink for EMC Investigations
2010
A CPU with a heat sink (e.g. Intel Pentium 4 and Intel Pentium dual core) is a challenging problem for EMC analysis. A Very Large Scale Integrated (VLSI) device was modelled using the Finite Element Method (FEM) frequency domain solver to obtain a 3D full wave solution. The electromagnetic (EM) radiation emitted from these high power microelectronic circuits connected to a heat sink was found to have resonant frequencies around 2.4 GHz and 5 GHz with reflection coefficients less than -19 dB and -8 dB respectively. These resonant frequencies are very close to the operating frequency of both IEEE and Bluetooth wireless communication systems. This paper proposes a new benchmark model based on …