Search results for "Large"
showing 10 items of 2197 documents
Host-related factors and cancer: Malnutrition and non-Hodgkin lymphoma
2022
Assessment of host-related factors is a crucial aspect in the comprehensive management of cancer patients. A distinct nutritional disturbance linked to cancer has been recognized to be associated with negative outcomes. However, compared to solid tumors, only a limited number of studies have looked specifically at nutritional issues in the field of lymphoma. The aim of this review is to integrate the current knowledge on interactions between malnutrition and lymphoma and address most relevant and pertinent questions. We first provide a literature review on the mutual biological relationship between malnutrition and lymphoma. Next, we explore the overlap between malnutrition, sarcopenia, cac…
Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art
2019
The improvements in magnetic resonance imaging (MRI) technology and the concern related to the increased cancer risk in patients with lymphoma, also due to radiation exposure associated with imaging examinations, have led to the introduction of whole-body MRI (WB-MRI) as a radiation-free alternative to standard imaging procedures. WB-MRI seems a less histology-dependent functional imaging test than 18 F-fluorodeoxyglucose-positron emission tomography/CT (18 F-FDG-PET/CT). In patients with FDG-avid lymphomas, such as diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL), 18 F-FDG-PET/CT remains the imaging reference standard for staging, with WB-MRI potentially being a complementar…
ATLAS beam test results
1996
Many different configurations of electronics and-semiconductor strip detectors were studied in 1995 using the ATLAS tracking detector test area at the H8 beam-line of the CERN SPS. A significant fraction of these investigations are presented elsewhere in this volume and this paper will concentrate on the results with silicon strip detectors read out with electronics preserving the pulse height information. Data has been collected with the ADAM, APV5 and FElix read-out chips on a number of different detectors. The first results are presented for read out with LHC electronics of detectors to the ATLAS-A specification of 112.5 mu m pitch, employing n-strips in n-type silicon, capacitive coupli…
The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation of N-Methyl-D-aspartate Rec…
2008
The low density lipoprotein receptor-related protein 1 (LRP1) emerges to play fundamental roles in cellular signaling pathways in the brain. One of its prominent ligands is the serine proteinase tissue-type plasminogen activator (tPA), which has been shown to act as a key activator of neuronal mitogen-activated protein kinase pathways via the N-methyl-D-aspartate (NMDA) receptor. However, here we set out to examine whether LRP1 and the NMDA receptor might eventually act in a combined fashion to mediate tPA downstream signaling. By blocking tPA from binding to LRP1 using the receptor-associated protein, we were able to completely inhibit NMDA receptor activation. Additionally, inhibition of …
U937 variant cells as a model of apoptosis without cell disintegration
2012
AbstractThe variant cell line U937V was originally identified by a higher sensitivity to the cytocidal action of tumor necrosis factor alpha (TNFα) than that of its reference cell line, U937. We noticed that a typical morphological feature of dying U937V cells was the lack of cellular disintegration, which contrasts to the formation of apoptotic bodies seen with dying U937 cells. We found that both TNFα, which induces the extrinsic apoptotic pathway, and etoposide (VP-16), which induces the intrinsic apoptotic pathway, stimulated U937V cell death without cell disintegration. In spite of the distinct morphological differences between the U937 and U937V cells, the basic molecular events of ap…
Barbarians at the gate... the ideas of Europe in CEE
2011
The central aim of this work is to present some ideas of Europe in Central and Eastern Europe through three phases, the Soviet period, the pre-accession (to the EU) period and, finally, the post-accession period. Throughout those periods, Central and Eastern European states faced different conditions and challenges however Europe consistently remained a point of reference in the states’ intellectual and political reflections. This work is meant to contribute to understanding the rationale and reason behind the policy directions chosen in CEE in the later half of the 20th and formative part of the 21st centuries.
A True Extension of the Markov Inequality to Negative Random Variables
2020
The Markov inequality is a classical nice result in statistics that serves to demonstrate other important results as the Chebyshev inequality and the weak law of large numbers, and that has useful applications in the real world, when the random variable is unspecified, to know an upper bound for the probability that an variable differs from its expectation. However, the Markov inequality has one main flaw: its validity is limited to nonnegative random variables. In the very short note, we propose an extension of the Markov inequality to any non specified random variable. This result is completely new.
Radioisotopic determination of l-carnitine content in foods commonly eaten in Western countries
2004
Abstract l -Carnitine is a vitamin-like nutrient essential for energy production and lipid metabolism in many organs and tissues such as skeletal muscle and heart. Even if l -carnitine can be synthesized, most of the carnitine present in human body is provided by food. Until now, no large study has been conducted where the content in l -carnitine of various foods was analyzed. The objective of this study was to determine the level of free l -carnitine present in food commonly consumed in Western countries. A radioisotopic assay was used to estimate l -carnitine content in raw and processed foods. From this study, it clearly appeared that meat products were the best sources for l -carnitine.…
Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature
2021
Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic lymphoma kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report a pediatric case of ALK-positive ALCL with primary concomitant involvement of bone and central nervous system (CNS); thereafter, a literature review about pediatric primary bone and primary CNS ALCL was conducted. According to the analyzed data, our case is unique because it is characterized by the contemporary involvement of the spine and CNS. During and after chemotherapy, our patient was monitored by detecting minimal residual disease (MRD) through the analysis of fusio…
How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?
2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H. (project 132619) and M.K. (projects 268214 and 272927), a grant from NERC, UK to M.G.R. (grant NE/J020818/1), and NERC, UK PhD studentship to D.J.P. (NE/I528634/1). For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace chang…