Search results for "Larsen"
showing 4 items of 4 documents
Ectosymbiosis associated with cidaroids (Echinodermata: Echinoidea) promotes benthic colonization of the seafloor in the Larsen Embayments, Western A…
2011
7 pages; International audience; Ice-shelf collapses in the Larsen A and B embayments along the Weddell side of the Antarctic Peninsula resulted in new open-water areas that are likely reorganizing benthic communities. It is a natural laboratory to assess colonization of the sea bottom under new conditions. We tested the hypothesis that the epibionts associated to cidaroid echinoids could promote or enhance the colonization of hard surfaces. In fact, being vagile, cidaroids might improve dispersal capabilities of the sessile animals that are attached to their spines, e.g., promoting the colonization of areas where the fauna has been eradicated by iceberg scouring. If this hypothesis is corr…
Skeletal Dysplasia Mutations Effect on Human Filamins’ Structure and Mechanosensing
2016
AbstractCells’ ability to sense mechanical cues in their environment is crucial for fundamental cellular processes, leading defects in mechanosensing to be linked to many diseases. The actin cross-linking protein Filamin has an important role in the conversion of mechanical forces into biochemical signals. Here, we reveal how mutations in Filamin genes known to cause Larsen syndrome and Frontometaphyseal dysplasia can affect the structure and therefore function of Filamin domains 16 and 17. Employing X-ray crystallography, the structure of these domains was first solved for the human Filamin B. The interaction seen between domains 16 and 17 is broken by shear force as revealed by steered mo…
Chondrodysplasia with multiple dislocations: comprehensive study of a series of 30 cases
2017
The group of chondrodysplasia with multiple dislocations includes several entities, characterized by short stature, dislocation of large joints, hand and/or vertebral anomalies. Other features, such as epiphyseal or metaphyseal changes, cleft palate, intellectual disability are also often part of the phenotype. In addition, several conditions with overlapping features are related to this group and broaden the spectrum. The majority of these disorders have been linked to pathogenic variants in genes encoding proteins implicated in the synthesis or sulfation of proteoglycans (PG). In a series of 30 patients with multiple dislocations, we have performed exome sequencing and subsequent targeted…
Mustan auringon paketti : myytti ja melankolia Irene Larsenin kokoelmassa Sortsolsafari
2015
In this article, I analyse how the Sámi poet Irene Larsen rewrites Sámi oral tradition and mythology in her collection Sortsolsafari (2013, “Black Sun Safari”). I discuss how Larsen’s work differs from the mainstream of contemporary Sámi poetry and other indigenous literatures. Sortsolsafari has postmodernist features, which seldom are found in Sámi literature. Larsen situates mythological elements in present-day reality: a Sámi goddess uses a sewing machine and a shaman logs on to the Internet. These anachronisms create a comical effect. Instead of nostalgia and anti-colonialism, which traditionally characterize the depiction of the past in Sámi literature, the overall tone of Sortsolsafar…