Search results for "Larynx"
showing 2 items of 72 documents
Schwannoma of the larynx. Case report
2005
Neuretogenous tumours of the larynx are extremely uncommon. We present a case of schwannoma of the larynx and review pertinent data in the literature. Laryngeal schwannoma was discovered in a 80-year-old woman who complained of persistent dysphonia. The histological findings leading to diagnosis together with the therapeutic surgical procedure are described. There was no postoperative complication and functional outcome was excellent at six months follow-up, demonstrating that conservative surgery is required for this type of disease. Conservative surgery provides excellent results. Although very rare, schwannoma should be taken into consideration in the differential diagnosis of any laryng…
TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma
2005
To prospectively evaluate the prognostic significance of TP53, H-, K-, and N-Ras mutations, DNA-ploidy and S-phase fraction (SPF) in patients affected by locally advanced laryngeal squamous cell carcinoma (LSCC). Eight-one patients (median follow-up was 71 months) who underwent resective surgery for primary operable locally advanced LSCC were analyzed. Tumor DNA was screened for mutational analysis by PCR/SSCP and sequencing. DNA-ploidy and SPF were performed by flow cytometric analyses. Thirty-six patients (44%) had, at least, a mutation in the TP53 gene. Of them, 22% (8/36) had double mutations and 3% (1/36) had triple mutations. In total, 46 TP53 mutations were observed. The majority (41…