Search results for "Lease"

showing 10 items of 886 documents

The role of saliva in aroma release and perception

2017

Aroma perception is an important factor driving food acceptance. Volatile organic compounds (VOCs) are released from the food matrix and then reach the receptors located in the nasal cavity, leading to their perception. These steps are closely dependent on the physicochemical properties of the volatile compounds and the food matrix, but also on human physiology. Among the different physiological parameters involved, the literature reports that saliva has various effects on VOCs and therefore appears as a major actor impacting the perception of aroma. This article reviews how saliva takes part in aroma release, considering both in vitro and in vivo approaches, and how it may affect perceptio…

Salivavolatile organic compound[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutritionmedia_common.quotation_subjectsalivary proteinsprotéine salivaireAnalytical Chemistry0404 agricultural biotechnologyPerceptionvolatile organic compoundsHumansflaveurFood sciencesaliveAromamedia_commonenzymatic reactionAffect perceptionMolecular interactionssalivabiologyChemistryenzymatic conversioncomposé organique volatilFood acceptancefood and beverages04 agricultural and veterinary sciencesGeneral MedicineHuman physiologymucinslibération d'arômeinteractionsbiology.organism_classification040401 food scienceflavourBiochemistryaroma releaseOdorantsréaction enzymatiquePerceptionIndirect impact[SDV.AEN]Life Sciences [q-bio]/Food and NutritionFood Science
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Centromeric heterochromatin and satellite DNA in the Chironomus plumosus species group

1994

Species of the Chironomus plumosus group display significant differences in their amount of centromeric heterochromatin. A tandem-repetitive satellite-like DNA has been isolated from C. plumosus. This DNA accounts for a major part of the centromeric heterochromatin. The DNA element has a Sau3AI restriction site ("Sau elements") and a monomer length of 165 or 166 bp. It is A-T rich (73%) and reveals a moderate DNA curvature, as shown by gel migration and computer analysis. The chromosomal localization and genomic organization of Sau elements were studied in 24 Chironomus species by in situ hybridization and (or) Southern analysis. The DNA is predominantly located in the centromeric regions …

Satellite DNACentromereMolecular Sequence DataIn situ hybridizationDNA SatelliteChironomidaechemistry.chemical_compoundSpecies SpecificityHeterochromatinCentromereGeneticsAnimalsChironomus plumosusCloning MolecularDeoxyribonucleases Type II Site-SpecificMolecular BiologyIn Situ HybridizationPhylogenyGenomic organizationGeneticsBase SequencebiologySequence Analysis DNAGeneral Medicinebiology.organism_classificationMolecular biologyRestriction sitechemistryNucleic Acid ConformationChironomusDNABiotechnologyGenome
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Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

2021

Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we show that nuclear envelope ruptures induce DNA damage that promotes senescence in non-transformed cells and induces an invasive phenotype in human breast cancer cells. We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1-dependent DNA damage, thereby driving the …

SenescenceExonucleaseDNA damageNuclear Envelope[SDV]Life Sciences [q-bio]Breast NeoplasmsBiologySettore MED/08 - Anatomia PatologicaGeneral Biochemistry Genetics and Molecular BiologyCell LineMicemedicineSettore MED/05 - Patologia ClinicaAnimalsHumansNeoplasm InvasivenessEpithelial–mesenchymal transitionCellular SenescenceEndoplasmic reticulumPhosphoproteinsXenograft Model Antitumor AssaysCell biology[SDV] Life Sciences [q-bio]medicine.anatomical_structureExodeoxyribonucleasesCancer cellProteolysisbiology.proteinTREX1 nuclear envelope rupture DNA damage mammary duct carcinoma tumor invasion senescence breast cancer cGAS confinement epithelial to mesenchymal transition Animals Breast Neoplasms Cell Line Cellular Senescence Collagen Disease Progression Exodeoxyribonucleases Female Humans Mice Neoplasm InvasivenessNuclear Envelope PhosphoproteinsProteolysis Xenograft Model Antitumor Assays DNA DamageDisease ProgressionFemaleCollagenNucleusExtracellular Matrix DegradationDNA Damage
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Isolation of Vibrio vulnificus Serovar E from Aquatic Habitats in Taiwan

1999

ABSTRACT The existence of strains of Vibrio vulnificus serovar E that are avirulent for eels is reported in this work. These isolates were recovered from water and oysters and differed from eel virulent strains in (i) fermentation and utilization of mannitol, (ii) ribotyping after Hin dIII digestion, and (iii) susceptibility to eel serum. Lipopolysaccharide of these strains lacked the highest molecular weight immunoreactive bands, which are probably involved in serum resistance.

SerotypeBlood Bactericidal Activityendocrine systemanimal structuresTaiwanVirulenceDeoxyribonuclease HindIIIVibrio vulnificusApplied Microbiology and BiotechnologyMicrobiologyRibotypingVibrionaceaeVibrio InfectionsAnimalsHumansSeawaterSerotypingVibrioEelsVirulenceEcologybiologybiology.organism_classificationOstreidaeVibrioBacterial Typing TechniquesOstreidaeEnvironmental and Public Health MicrobiologyVibrio InfectionsbacteriaWater MicrobiologyFood ScienceBiotechnologyApplied and Environmental Microbiology
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STRUCTURAL AND FUNCTIONAL RESPONSES OF FISH ASSEMBLAGES TO DIFFERENT DRIVERS OF CHANGE

Biotic and abiotic factors synergistically act on natural systems. As a result ecological communities adjust their structural and functional responses to persist in a given area. Worldwide, marine ecosystems have been changing through time with increasing anthropogenic pressure in the last centuries leading to only 13.2% of the total marine environments in a ‘pristine’ state. The consequences of direct and indirect anthropogenic pressures may have on marine organisms can largely differ, with both negative and positive effects of drivers of change of human origin. In the span of three years for my PhD thesis, I performed different experiments with the main goal of examining how direct or ind…

Settore BIO/07 - EcologiaFish assemblageMesopredator ReleaseOcean AcidificationMarine Protected Area
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Flavonoids against the SARS-CoV-2 induced inflammatory storm

2021

The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out …

Settore BIO/17 - Istologia0301 basic medicinePhytochemicalsAnti-Inflammatory AgentsAnti-inflammatory effectsInflammationRM1-950ReviewCytokine stormProinflammatory cytokineImmunomodulationEndothelial activation03 medical and health sciences0302 clinical medicineImmune systemAnimalsHumansMedicineDipeptidyl peptidase-4InflammationFlavonoidsPharmacologySARS-CoV-2business.industryfungiCOVID-19food and beveragesInflammasomeGeneral Medicinemedicine.diseaseCOVID-19 Drug Treatment3. Good health030104 developmental biology030220 oncology & carcinogenesisImmunologyTherapeutics. Pharmacologymedicine.symptomSignal transductionCytokine Release SyndromebusinessCytokine stormmedicine.drugBiomedicine & Pharmacotherapy
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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POLYSACCHARIDE-POLYAMINOACID HYDROGEL FILMS FOR POTENTIAL CORNEAL CELL RELEASE

2009

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoHIDROGELS CORNEAL RELEASE.
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MODIFIED PEPTIDE RELEASE FROM NEW IN SITU GEL FORMING COPOLYMERS BASED ON POLYLACTIDE AND POLYASPARTAMIDE

2008

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoPEPTIDE RELEASE GEL POLYASPARTAMIDE POLYESTER
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Sviluppo di spugne bioerodibili multifunzionali per la promozione di processi riparativi mediante il rilascio controllato di agenti antibiotici e ant…

2023

La salute delle strutture molli e dure del cavo orale è essenziale non solo per preservare le funzioni ad esse direttamente associate, ma anche per promuovere la salute generale dell’organismo. Tra le problematiche di maggiore interesse clinico a carico della cavità orale ritroviamo: i) le complicazioni post-operatorie che possono verificarsi a seguito di comuni avulsioni dentali che, se non trattate tempestivamente, possono sfociare in gravi parodontiti; ii) i fenomeni di osteonecrosi a carico di mascella e mandibola associate a trattamenti farmacologici nonché alla radioterapia; iii) il carcinoma orale a cellule squamose (OSCC) che è tra i più aggressivi tumori del collo e della testa, ca…

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoSettore MED/28 - Malattie Odontostomatologicheoral disease polyphenols drug delivery system nanostructured lipid carrier nanocomposite polymeric microparticle spray drying 3D-printed scaffold wound healing controlled drug release kinetic evaluation.
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