Search results for "Lee"
showing 10 items of 1847 documents
Beta-blockers for preventing variceal bleeding
1990
Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.
2012
Background: Intermittent hypoxia and obesity which are two pathological conditions commonly found in patients with obstructive sleep apnea (OSA), potentially enhance cancer progression. Objective: To investigate whether obesity and/or intermittent hypoxia (IH) mimicking OSA affect tumor growth. Methods: A subcutaneous melanoma was induced in 40 mice [22 obese (40–45 g) and 18 lean (20–25 g)] by injecting 106 B16F10 cells in the flank. Nineteen mice (10 obese/9 lean) were subjected to IH (6 h/day for 17 days). A group of 21 mice (12 obese/9 lean) were kept under normoxia. At day 17, tumors were excised, weighed and processed to quantify necrosis and endothelial expression of vascular endothe…
European Sea Bass (Dicentrarchus labrax) immune status and disease resistance are impaired by arginine dietary supplementation
2015
Infectious diseases and fish feeds management are probably the major expenses in the aquaculture business. Hence, it is a priority to define sustainable strategies which simultaneously avoid therapeutic procedures and reinforce fish immunity. Currently, one preferred approach is the use of immunostimulants which can be supplemented to the fish diets. Arginine is a versatile amino acid with important mechanisms closely related to the immune response. Aiming at finding out how arginine affects the innate immune status or improve disease resistance of European seabass (Dicentrarchus labrax) against vibriosis, fish were fed two arginine-supplemented diets (1% and 2% arginine supplementation). A…
Miega kvalitātes rādītāju saistība ar vizuālās uztveres spējām
2020
Bakalaura darba pētījuma mērķis bija noskaidrot, vai cilvēkiem ar augstākiem miega kvalitātes rādītājiem ir precīzāka vizuālā uztvere. Pētījumā piedalījās 56 pieaugušie (34 sievietes; 22 vīrieši) vecumā no 18 līdz 63 gadiem (M=36,60, SD=12,90). Pētījumā tika izmantotas šādas metodes: Pitsburgas miega kvalitātes indeksa aptauja un Vizuālās uztveres tests. Pētījumā iegūtie rezultāti norāda, ka konkrētajā izlasē pastāv statistiski nozīmīgas korelācijas. Uzrādījās statistiski nozīmīga negatīva korelācija starp vizuālās uztveres testa rezultātiem un miega traucējumu apakšskalu; starp vizuālās uztveres testa rezultātiem un iemigšanas laika apakšskalu; starp vizuālās uztveres testa rezultātiem un …
Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis
2012
Background and purpose: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Although sleep disturbances are a candidate factor that may interfere with fatigue in patients with ALS, the role of sleep-related abnormalities in determining fatigue in ALS is unknown. Objective: To evaluate the frequency and determinants of fatigue in a group of 91 consecutive patients with ALS, with special attention to the relationship between fatigue and sleep problems. Methods: Measures included the Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), ALS Functional Rating ScaleRevised (ALSFRS-R), and Beck Depression Inventory (BDI). Results: The…
Effective hemostasis during minor surgery in a case of hereditary combined deficiency of vitamin K-dependent clotting factors.
2009
Combined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a rare bleeding disorder involving defective gamma-carboxylation of coagulation factors II , VII, IX and X as well as natural anticoagulants protein C and protein S. The disease is characterized by a cluster of different, often life threatening, bleeding symptoms occurring both spontaneously and in a surgical setting. In the present paper we describe two different treatment modalities to be used both in a programmed surgical procedure and in an emergency scenario. As this disease is a natural model that resembles oral anticoagulation, our experience discloses a possible rationale in the use of recombinant activated …
Vitamin A in parenteral nutrition: uptake and distribution of retinyl esters after intravenous application.
1989
Short-term parenteral application of vitamin A was examined in rats. Retinyl margarinate, which is chemically similar to physiological retinyl esters, was used in vitamin A-depleted rats to study uptake, distribution, and storage of retinyl esters in tissues. Vitamin A-depleted and Vitamin A-sufficient rats were infused with a micellar suspension of retinyl margarinate for 7 h and then killed at different times. Retinyl margarinate was directly taken up by all tissues examined. It appears that infusion of retinyl esters in micellar form provides a direct way to supply vitamin A to peripheral, vitamin A-dependent tissues. Therefore, a short-term infusion of retinyl esters with an emulsifier …
Hereditary combined deficiency of the vitamin K-dependent clotting factors
2010
Abstract Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding symptoms are often life-threatening, occur both spontaneously and in a surgical setting, and usually involve the skin and mucosae. A range of non-haemostatic symptoms are often present, including developmental and skeletal anomalies. VKCFD is an autosomal recessive disorder caused by mutations in …
ELM Regularized Method for Classification Problems
2016
Extreme Learning Machine (ELM) is a recently proposed algorithm, efficient and fast for learning the parameters of single layer neural structures. One of the main problems of this algorithm is to choose the optimal architecture for a given problem solution. To solve this limitation several solutions have been proposed in the literature, including the regularization of the structure. However, to the best of our knowledge, there are no works where such adjustment is applied to classification problems in the presence of a non-linearity in the output; all published works tackle modelling or regression problems. Our proposal has been applied to a series of standard databases for the evaluation o…
Der Spur auf der Spur. Sur les traces de la trace
2016
Hinter dem scheinbar einfachen lexikalischen Gewand der »Spur« verbirgt sich eine überraschende Komplexität: Was ist eigentlich eine Spur? Was sind ihre typischen Merkmale? Wodurch unterscheidet sie sich von Abdruck, Zeichen und Indiz? Die Beiträge des vorliegenden Bandes reflektieren den Spurbegriff aus deutsch-französischer sowie aus interdisziplinärer Perspektive. Zu Wort kommen Philosophie, Literatur, Geschichte, Archäologie, Kunstgeschichte, Urbanistik, Kulturwissenschaft und Psychoanalyse.