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showing 10 items of 819 documents

Type IV Laryngotracheoesophageal Cleft Associated with Type III Esophageal Atresia in 1p36 Deletions Containing the RERE Gene: Is There a Causal Role…

2018

The causes of embryological developmental anomalies leading to laryngotracheoesophageal clefts (LTECs) are not known, but are proposed to be multifactorial, including genetic and environmental factors. Haploinsufficiency of the RERE gene might contribute to different phenotypes seen in individuals with 1p36 deletions. We describe a neonate of an obese mother, diagnosed with type IV LTEC and type III esophageal atresia (EA), in which a 1p36 deletion including the RERE gene was detected. On the second day of life, a right thoracotomy and extrapleural esophagus atresia repair were attempted. One week later, a right cervical approach was performed to separate the cervical esophagus from the tra…

0301 basic medicinemedicine.medical_specialtyType IV Laryngotracheoesophageal Cleft Type III Esophageal Atresia 1p36 Deletions RERE Genemedicine.medical_treatmentAnastomosisGastroenterology03 medical and health sciences0302 clinical medicineInternal medicineMedicineThoracotomyEsophagus030223 otorhinolaryngologyEpigenomicsbusiness.industrylcsh:RJ1-570lcsh:PediatricsGeneral Medicinemedicine.diseasePhenotype030104 developmental biologymedicine.anatomical_structureAtresiaFailure to thrivemedicine.symptombusinessHaploinsufficiencyCase Reports in Pediatrics
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A Perspective : Active Role of Lipids in Neurotransmitter Dynamics

2019

AbstractSynaptic neurotransmission is generally considered as a function of membrane-embedded receptors and ion channels in response to the neurotransmitter (NT) release and binding. This perspective aims to widen the protein-centric view by including another vital component—the synaptic membrane—in the discussion. A vast set of atomistic molecular dynamics simulations and biophysical experiments indicate that NTs are divided into membrane-binding and membrane-nonbinding categories. The binary choice takes place at the water-membrane interface and follows closely the positioning of the receptors’ binding sites in relation to the membrane. Accordingly, when a lipophilic NT is on route to a m…

0301 basic medicinesynaptic neurotransmissionSynaptic cleftNeuroscience (miscellaneous)NeurotransmissionlipiditSynaptic vesicleSynaptic TransmissionSynaptic neurotransmissionArticlesolukalvotmembrane lipid composition (MLC)03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compound0302 clinical medicineSynaptic receptormembrane-based sortingAnimalsHumansmolekyylidynamiikkaNeurotransmittermolecular dynamics (MD)Binding siteNeurotransmitterReceptorvälittäjäaineetIon channelNeurotransmitter AgentsmolekyylineurologiaMembrane lipid composition (MLC)Molecular dynamics (MD)Lipid MetabolismLipids030104 developmental biologyNeurologychemistrySynapsesBiophysicsSynaptic VesiclessynapsitMembrane-based sorting030217 neurology & neurosurgeryFunction (biology)neurotransmittersynaptic receptor
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Studies to Elucidate the Mechanism of Cardio Protective and Hypotensive Activities of Anogeissus acuminata (Roxb. ex DC.) in Rodents

2020

Anogeissus acuminata (Roxb. ex DC.) is a folkloric medicinal plant in Asia

1Pharmaceutical Scienceacute myocardial infarction 3030204 cardiovascular system & hematologyPharmacologyCreatineAnalytical ChemistryNitric oxidelcsh:QD241-44103 medical and health scienceschemistry.chemical_compound0302 clinical medicinevasorelaxant 4lcsh:Organic chemistryIn vivoDrug DiscoveryRenin–angiotensin systemleft ventricular hypertrophy 2Physical and Theoretical ChemistryCyclic guanosine monophosphate030304 developmental biology0303 health sciencesbiologyOrganic ChemistryAngiotensin-converting enzymehypotensivechemistryChemistry (miscellaneous)biology.proteinMolecular MedicineCreatine kinasehistopathology 6cardio relaxant 5Ex vivoMolecules
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Lamotrigine use in pregnancy and risk of orofacial cleft and other congenital anomalies

2016

Objective: To test previous signals of a risk of orofacial cleft (OC) and clubfoot with exposure to the antiepileptic lamotrigine, and to investigate risk of other congenital anomalies (CA).Methods: This was a population-based case–malformed control study based on 21 EUROCAT CA registries covering 10.1 million births (1995–2011), including births to 2005 in which the clubfoot signal was generated and a subsequent independent study population of 6.3 million births. A total of 226,806 babies with CA included livebirths, stillbirths, and terminations of pregnancy following prenatal diagnosis. First-trimester lamotrigine monotherapy exposure in OC cases and clubfoot cases was compared to other …

115congenital anomalies ; orofacial clefts ; lamotrigine ; pregnancy0302 clinical medicinePregnancyOdds RatioRegistries030212 general & internal medicineEPILEPSYeducation.field_of_studyTriazinesObstetricsAbsolute risk reductionANTIEPILEPTIC DRUGSAbnormalities Drug-InducedCleft PalateEuropeAnesthesiaINCREASED FREQUENCYAnticonvulsantsFemalemedicine.drugAdultRisk61medicine.medical_specialtyCleft LipPopulationPrenatal diagnosisLamotrigineLamotrigineSensitivity and SpecificityArticle03 medical and health sciencesJournal ArticlemedicineHumansAbnormalities Drug-Induced/epidemiology; Adult; Anticonvulsants/adverse effects; Anticonvulsants/therapeutic use; Case-Control Studies; Cleft Lip/chemically induced; Cleft Lip/epidemiology; Cleft Palate/chemically induced; Cleft Palate/epidemiology; Epilepsy/drug therapy; Epilepsy/epidemiology; Europe/epidemiology; Female; Humans; Odds Ratio; Pregnancy; Pregnancy Complications/drug therapy; Pregnancy Complications/epidemiology; Pregnancy Trimester First; Registries; Risk; Sensitivity and Specificity; Triazines/adverse effects; Triazines/therapeutic useMALFORMATIONSeducationPregnancy53business.industryCLUBFOOTCase-control studyOdds ratio228medicine.diseaseConfidence intervalPregnancy ComplicationsPregnancy Trimester FirstPALATECase-Control StudiesREGISTRYNeurology (clinical)business030217 neurology & neurosurgeryNeurology
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The working partner in family enterprise : European and national issues

2021

The essay focuses on the discipline of the work done by one partner in the company of the other in cross-border couples and on the problems involved in this case. More specifically the focus is on the hermeneutical problems that arise both at the level of European legislation and at the level of Italian national discipline which is applicable according to European conflict criteria, showing the ambiguities and wide areas of shadow left uncovered by the latter.

:CIENCIAS JURÍDICAS [UNESCO]familiasociedad registradafamilycross-border couple2386-4567 22661 Actualidad jurídica iberoamericana 587897 2021 15 8113557 The working partner in family enterprise European and national issues Pascucciregistered partnershippareja transfronterizade facto cohabitation.UNESCO::CIENCIAS JURÍDICASFederico The essay focuses on the discipline of the work done by one partner in the company of the other in cross-border couples and on the problems involved in this case. More specifically the focus is on the hermeneutical problems that arise both at the level of European legislation and at the level of Italian national discipline which is applicable according to European conflict criteriashowing the ambiguities and wide areas of shadow left uncovered by the latter. Workerconvivencia de hecho. 196 213Trabajador
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Las obras musicales en las radios universitarias

2018

The Spanish General Audiovisual Communication Law does not relate to Campus Radio Stations. In this context, Copyright Collection Societies do not cover them in their catalogues of general fees. For this reason, the holders of these radios are forced to negotiate them. Althoug the Intellectual Property Law and the Order ECD/2574/2015, of 2 December, contain obligations for Copyright Collection Societies, on this matter its enforcement are far from being achieved

:CIENCIAS JURÍDICAS [UNESCO]on this matter its enforcement are far from being achieved Obras musicales2386-4567 22661 Actualidad jurídica iberoamericana 502169 2018 9 6653323 Las obras musicales en las radios universitarias López Sánchezcopyrightlicencias copyleftComputingMilieux_LEGALASPECTSOFCOMPUTINGtarifascopyleft licensescopyright collection societies. 136 175ComputingMilieux_GENERALMusical worksradios universitariasUNESCO::CIENCIAS JURÍDICASthe holders of these radios are forced to negotiate them. Althoug the Intellectual Property Law and the Order ECD/2574/2015campus radio stationspropiedad intelectualfeesCristina The Spanish General Audiovisual Communication Law does not relate to Campus Radio Stations. In this contextCopyright Collection Societies do not cover them in their catalogues of general fees. For this reasonof 2 Decembercontain obligations for Copyright Collection Societiesentidades de gestión colectiva
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Left Braces and the Yang-Baxter Equation

2021

L’equació quàntica de Yang-Baxter (YBE per les seues inicials en anglès) és una equació important en la física matemàtica introduïda per Yang en 1967. Un dels seus principals problemes oberts és trobar-ne totes les solucions. En 1992, Drinfeld va definir un subtipus de solucions, les conjuntistes, i va proposar el problema de trobar-les totes. Recentment, una subclasse de les solucions conjuntistes ha sigut molt estudiada: les involutives i no degenerades (a partir d’ara, les anomenarem simplement solucions). En 2007, Rump va introduir una nova estructura algebraica, les brides a esquerra, per a estudiar aquestes solucions, i va demostrar que cada brida a esquerra té una solució de la YBE a…

:MATEMÁTICAS::Álgebra::Grupos generalidades [UNESCO]UNESCO::MATEMÁTICAS::Álgebra::Grupos generalidadesleft bracesyang-baxter equation
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Fixed Points for Multivalued Convex Contractions on Nadler Sense Types in a Geodesic Metric Space

2019

In 1969, based on the concept of the Hausdorff metric, Nadler Jr. introduced the notion of multivalued contractions. He demonstrated that, in a complete metric space, a multivalued contraction possesses a fixed point. Later on, Nadler&rsquo

<b>54H25</b>Physics and Astronomy (miscellaneous)GeodesicGeneral MathematicsMathematics::General TopologyFixed-point theorem02 engineering and technologyFixed point01 natural sciencesComplete metric spacegeodesic metric spaceCombinatoricsregular golbal-inf function0202 electrical engineering electronic engineering information engineeringComputer Science (miscellaneous)0101 mathematicsMathematicsStatistics::Applicationslcsh:Mathematics010102 general mathematicsRegular polygonconvex multivalued left A-contractionlcsh:QA1-939Metric spaceHausdorff distancefixed point<b>47H10</b>Chemistry (miscellaneous)<title>MSC</title>020201 artificial intelligence & image processingright A-contractionSymmetry
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Child specific activation in left auditory cortex predicts behavioral performance in inhibition tasks

2020

Sensory processing during development is important for the emerging cognitive skills underlying goal-directed behavior. Yet, it is not known how auditory processing in children is related to their cognitive functions. Here, we utilized combined magneto- and electroencephalographic (M/EEG) measurements to show that child-unique auditory cortical activity at ∼250 ms after auditory stimulation predicts the performance in inhibition tasks. While unaffected by task demands, the amplitude of the left-hemisphere activation pattern was significantly correlated with the variability of behavioral response time. Since this activation pattern is not present in adults, our results suggest divergent brai…

Activity levelElementary cognitive taskmedicine.medical_specialtySensory processingmedicine.diagnostic_testmedicine.medical_treatment05 social sciencesCognitionElectroencephalographyAudiologyAuditory cortex050105 experimental psychology03 medical and health sciences0302 clinical medicinemedicine0501 psychology and cognitive sciencesLeft auditory cortexCognitive skillPsychology030217 neurology & neurosurgery
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P1319 Speckle tracking echocardiography in patients with acute coronary syndrome: the added value

2020

Abstract Background Speckle tracking echocardiography with assessment of left ventricular global longitudinal strain (GLS) allows to identify early signs of cardiac dysfunction. The superiority of GLS in the prediction of all-cause mortality in the general population compared with LVEF is well known; in addiction GLS improves risk stratification and recognize early left ventricular dysfunction in several clinical setting. Purpose the aim of this study was to assess the diagnostic and prognostic role of global and segmental strain in the early identification of cardiac dysfunction in patients with myocardial infarction without persistent ST segment elevation (NSTEMI) and without obvious wall…

Acute coronary syndromemedicine.medical_specialtyEjection fractionbusiness.industrySpeckle tracking echocardiographyGeneral Medicinemedicine.diseaseCircumflex branch of left coronary arteryInternal medicinemedicine.arterymedicineMedical imagingAdded valueCardiologyRadiology Nuclear Medicine and imagingMyocardial infarctionSystoleCardiology and Cardiovascular MedicinebusinessEuropean Heart Journal - Cardiovascular Imaging
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