Search results for "Leishmaniose"

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Practices in research, surveillance and control of neglected tropical diseases by One Health approaches: A survey targeting scientists from French-sp…

2021

One health (OH) approaches have increasingly been used in the last decade in the fight against zoonotic neglected tropical diseases (NTDs). However, descriptions of such collaborations between the human, animal and environmental health sectors are still limited for French-speaking tropical countries. The objective of the current survey was to explore the diversity of OH experiences applied to research, surveillance and control of NTDs by scientists from French-speaking countries, and discuss their constraints and benefits. Six zoonotic NTDs were targeted: echinococcoses, trypanosomiases, leishmaniases, rabies, Taenia solium cysticercosis and leptospiroses. Invitations to fill in an online q…

http://aims.fao.org/aos/agrovoc/c_8081RC955-962Psychological interventionSocial Scienceshttp://aims.fao.org/aos/agrovoc/c_431Computer-assisted web interviewingPolitical Aspects of HealthGlobal HealthSanté publique0302 clinical medicineMedical ConditionsArctic medicine. Tropical medicineSurveys and QuestionnairesPublic and Occupational Healthhttp://aims.fao.org/aos/agrovoc/c_6970media_commonMammalsSanté animaleNeglected DiseasesEukaryota3. Good healthÉpidémiologie[SDV] Life Sciences [q-bio]http://aims.fao.org/aos/agrovoc/c_1790medicine.drug_formulation_ingredientOne Healthhttp://aims.fao.org/aos/agrovoc/c_2085Veterinary Diseases[SDE]Environmental SciencesPublic aspects of medicinehttp://aims.fao.org/aos/agrovoc/c_4027http://aims.fao.org/aos/agrovoc/c_8068http://aims.fao.org/aos/agrovoc/c_8500medicine.medical_specialtyRabiesmedia_common.quotation_subjectPolitical ScienceLeptospiroseRage03 medical and health sciencesPolitical scienceTaenia soliumhttp://aims.fao.org/aos/agrovoc/c_3081HumansSurveillance épidémiologiquehttp://aims.fao.org/aos/agrovoc/c_8530Survey ResearchPublic Health Environmental and Occupational HealthOrganismsBiology and Life SciencesTropical Diseaseshttp://aims.fao.org/aos/agrovoc/c_7558http://aims.fao.org/aos/agrovoc/c_6349http://aims.fao.org/aos/agrovoc/c_4281Veterinary ScienceDiversity (politics)[SDE] Environmental SciencesViral DiseasesBiomedical Researchhttp://aims.fao.org/aos/agrovoc/c_2615[SDV]Life Sciences [q-bio]http://aims.fao.org/aos/agrovoc/c_870SurveysL73 - Maladies des animauxhttp://aims.fao.org/aos/agrovoc/c_875http://aims.fao.org/aos/agrovoc/c_16411http://aims.fao.org/aos/agrovoc/c_7988http://aims.fao.org/aos/agrovoc/c_6416ZoonosesTrypanosomoseMedicine and Health Sciences030212 general & internal medicinehttp://aims.fao.org/aos/agrovoc/c_3423http://aims.fao.org/aos/agrovoc/c_5164http://aims.fao.org/aos/agrovoc/c_4510http://aims.fao.org/aos/agrovoc/c_16415EchinococcoseInfectious DiseasesResearch DesignS50 - Santé humaineVertebrateshttp://aims.fao.org/aos/agrovoc/c_7979Neglected tropical diseasesRA1-1270Zone tropicaleResearch ArticleNeglected Tropical Diseaseszoonosehttp://aims.fao.org/aos/agrovoc/c_28665030231 tropical medicineMEDLINEResearch and Analysis Methodshttp://aims.fao.org/aos/agrovoc/c_259http://aims.fao.org/aos/agrovoc/c_35197DogsEnvironmental healthTropical MedicinemedicineLeishmanioseAnimalsCysticercosehttp://aims.fao.org/aos/agrovoc/c_5181Enquête pathologique[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieTropical medicineAmniotes[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieZoology
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TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

2020

A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the transcriptional profile of human VL to demonstrate that the TLR4-IFN-β pathway regulates the chronic inflammatory process and is associated with the asymptomatic form of the disease. Tlr4-deficient mice harbored fewer parasites in their spleen and liver than wild-type mice. TLR4 deficiency enhanced the Th1 immune response against the parasite, which was correlated with an increased activation of de…

PhysiologyGene ExpressionWhite Blood CellsMiceCell SignalingAnimal CellsImmune PhysiologyZoonosesImmunopathologyMedicine and Health SciencesMembrane Receptor SignalingBiology (General)Immune ResponseLeishmaniasisProtozoansLeishmaniaMice Knockout0303 health sciencesbiologyT Cells030302 biochemistry & molecular biologyEukaryotaImmune Receptor SignalingInfectious Diseasesmedicine.anatomical_structureLeishmaniasis VisceralCellular Typesmedicine.symptomLeishmania infantumResearch ArticleSignal TransductionNeglected Tropical DiseasesQH301-705.5Leishmania InfantumImmune CellsImmunologySpleenInflammationLEISHMANIOSE VISCERALMicrobiology03 medical and health sciencesImmune systemVirologyParasitic DiseasesGeneticsmedicineAnimalsMolecular Biology030304 developmental biologyInflammationProtozoan InfectionsBlood CellsOrganismsBiology and Life SciencesCell BiologyInterferon-betaTh1 CellsRC581-607Tropical Diseasesmedicine.diseasebiology.organism_classificationParasitic ProtozoansToll-Like Receptor 4IRF1Visceral leishmaniasisImmunologyTLR4ParasitologyImmunologic diseases. AllergySpleenInterferon Regulatory Factor-1
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