Search results for "Lemi"

showing 10 items of 513 documents

Foucault and Agamben on Augustine, Paradise and the Politics of Human Nature

2023

This article focuses on Foucault’s and Agamben’s readings of Augustine’s account of human nature and original sin. Foucault’s analysis of Augustine’s account of sexual acts in paradise, subordinated to will and devoid of lust, highlights the way it constitutes the model for the married couple, whose sexual acts are only acceptable if diverted by the will away from desire and towards the tasks of procreation. While Agamben rejects Augustine’s doctrine of original sin and reclaims paradise as the original homeland of humanity, his reappropriation of paradise remains conditioned by our turn towards our true nature, from which we have been estranged by sin. Agamben’s politics of reclaiming par…

Agamben GiorgioSociology and Political ScienceAugustinemessianismtotteleminenGeneral Social SciencesnatureluontosyntimessianismiperisyntimoraaliFoucault MichelihmisyysparatiisiobedienceetiikkaparadiseTheory, Culture & Society
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Hypovolaemia-induced metabolic dysfunction, mediated in part by aldosterone and angiotensin

2009

Angiotensin receptormedicine.medical_specialtyAldosteroneAngiotensin II receptor type 1Physiologybusiness.industrychemistry.chemical_compoundEndocrinologychemistryHypovolemiaInternal medicineRenin–angiotensin systemInternal Medicinemedicinemedicine.symptomCardiology and Cardiovascular MedicinebusinessJournal of Hypertension
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ETC-1002: A future option for lipid disorders?

2014

ETC-1002 is a new investigational low density lipoprotein cholesterol (LDL-C)-lowering agent (Esperion Therapeutics, Inc.). ETC-1002 is a dicarboxylic acid derivative with a novel mechanism of action targeting two hepatic enzymes - adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK), inhibiting sterol and fatty acid synthesis and promoting mitochondrial long-chain fatty acid oxidation. This agent is currently in phase II clinical research. Available data report that ETC-1002 significantly decreased LDL-C levels (up to 32%) in both patients with normal and elevated baseline levels of triglycerides. Such beneficial effect is superior to curre…

Apolipoprotein BLow density lipoprotein cholesterolBlood PressureAMP-Activated Protein Kinaseschemistry.chemical_compoundMiceMulticenter Studies as TopicDicarboxylic AcidsBeta oxidationHypolipidemic AgentsRandomized Controlled Trials as TopicHypolipidemic AgentbiologyFatty AcidsHyperlipidemiaTolerabilityLiverlipids (amino acids peptides and proteins)Cardiology and Cardiovascular MedicineAMP-Activated Protein Kinasemedicine.drugHumanmedicine.medical_specialtyStatinmedicine.drug_classHypercholesterolemiaHyperlipidemiasClinical Trials Phase II as TopicInternal medicinemedicineAnimalsHumansFatty acid synthesisApolipoproteins BAnimalBody WeightDicarboxylic AcidAMPKCholesterol LDLAdenosineSterolCardiometabolic riskRatsETC-1002Disease Models AnimalEndocrinologychemistrybiology.proteinATP Citrate (pro-S)-LyaseRatFatty AcidLipid lowering therapy
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Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis

2020

Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…

Apolipoprotein BPublication Ethics030204 cardiovascular system & hematologyCardiovascularGastroenterologyLipoprotein particleMedical and Health SciencesBiochemistrychemistry.chemical_compoundDatabase and Informatics Methods0302 clinical medicineMathematical and Statistical TechniquesAnticholesteremic Agents Apolipoproteins B Cholesterol Cholesterol LDL Clinical Trials Phase II as Topic Clinical Trials Phase III as Topic Dicarboxylic Acids Fatty Acids Humans Hypercholesterolemia Peptide Fragments Randomized Controlled Trials as TopicLipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group and the International Lipid Expert PanelMedicine and Health SciencesDicarboxylic Acids030212 general & internal medicineDatabase SearchingResearch IntegrityRandomized Controlled Trials as Topicmedicine.diagnostic_testbiologyAnticholesteremic AgentsStatisticsFatty AcidsRDrugsGeneral MedicineMetaanalysisSerious Mental IllnessLipidsPhase III as TopicMental HealthCholesterolPhysical SciencesMedicineResearch Articlemedicine.medical_specialtyRMScience PolicyLipoproteinsHypercholesterolemiaBempedoic acid hypercholesterolemia lipid profile hsCRPResearch and Analysis MethodsLDL03 medical and health sciencesClinical Trials Phase II as TopicInternal medicineGeneral & Internal MedicinemedicineHumansClinical TrialsStatistical MethodsApolipoproteins BPharmacologyPlasma Proteinsbusiness.industryCholesterolPhase II as TopicStatinsBiology and Life SciencesProteinsOdds ratioCholesterol LDLConfidence intervalPeptide FragmentschemistryClinical Trials Phase III as Topicbiology.proteinUric acidCreatine kinaseLipid profilebusinessDigestive DiseasesMathematicsPLoS Medicine
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Identification Of P.Leu167Del Apoe Gene Mutation By Next Generation Sequencing In A Large Hypercholesterolemic Family

2019

Apolipoprotein EGeneticsSettore MED/09 - Medicina InternaNEXT GENERATION SEQUENCING HYPERCHOLESTEROLEMIAMutation (genetic algorithm)APOE GENEIdentification (biology)BiologyCardiology and Cardiovascular MedicineMUTATIONDNA sequencingAtherosclerosis
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Genetic polymorphisms affecting the phenotypic expression in familial hypercholesterolemia

2004

The clinical expression of heterozygous familial hypercholesterolemia (FH) is highly variable even in patients carrying the same LDL receptor (LDL-R) gene mutation. This variability might be due to environmental factors as well as to modifying genes affecting lipoprotein metabolism. We investigated Apo E (2, 3, 4), MTP (-493G/T), Apo B (-516C/T), Apo A-V (-1131T/C), HL (-514C/T and -250G/A), FABP-2 (A54T), LPL (D9N, N291S, S447X) and ABCA1 (R219K) polymorphisms in 221 unrelated FH index cases and 349 FH relatives with defined LDL-R gene mutations. We found a significant and independent effect of the following polymorphisms on: (i) plasma LDL-C (Apo E, MTP and Apo B); (ii) plasma HDL-C (HL, …

Apolipoprotein EMaleSettore MED/09 - Medicina InternaApolipoprotein BFamilial hypercholesterolemiaGene mutationPolymerase Chain ReactionCoronary artery diseasecoronary artery disease; familial hypercholesterolemia; genetic polymorphisms; plasma lipidsCohort Studieschemistry.chemical_compoundGenotypePlasma lipidsOdds RatiobiologyFamilial hypercholesterolemia Plasma lipids Genetic polymorphisms Coronary artery diseaseIncidenceMiddle AgedPhenotypelipids (amino acids peptides and proteins)FemaleCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyMolecular Sequence DataFamilial hypercholesterolemiaPlasma lipidGenetic polymorphismsRisk AssessmentHyperlipoproteinemia Type IIFamilial hypercholesterolemia; Plasma lipids; Genetic polymorphisms; Coronary artery diseasePredictive Value of TestsInternal medicinemedicineConfidence IntervalsHumansGenetic Predisposition to DiseaseGenetic polymorphismPolymorphism GeneticBase SequenceCholesterolCholesterol HDLCase-control studyCholesterol LDLmedicine.diseaseEndocrinologyApolipoproteinschemistrySettore MED/03 - Genetica MedicaGene Expression RegulationReceptors LDLCase-Control StudiesLDL receptorbiology.protein
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Serum lipid responses to phytosterol-enriched milk in a moderate hypercholesterolemic population is not affected by apolipoprotein E polymorphism or …

2011

Background/Objectives: The importance of both low-density lipoprotein cholesterol (LDLc) size and the apolipoprotein E (Apo E) in the atherogenic process is known, but there is little information with regard to the effect of phytosterols (PS) on these parameters. The aim of this study was to evaluate the influence of PS on lipid profile and LDLc size according to Apo E genotype. Subjects/Methods: This was a randomized parallel trial employing 75 mild-hypercholesterolemic subjects and consisting of two 3-month intervention phases. After 3 months of receiving a standard healthy diet, subjects were divided into two intervention groups: a diet group (n = 34) and a diet+PS group (n = 41) that re…

Apolipoprotein EMalemedicine.medical_specialtyGenotype030309 nutrition & dieteticsPopulationHypercholesterolemiaMedicine (miscellaneous)030204 cardiovascular system & hematology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineApolipoproteins EDouble-Blind MethodInternal medicineHyperlipidemiamedicineAnimalsHumansParticle SizeeducationApolipoprotein e polymorphismTriglycerides0303 health scienceseducation.field_of_studyNutrition and DieteticsPolymorphism GeneticCholesterolPhytosterolCholesterol HDLPhytosterolsCholesterol LDLMiddle Agedmedicine.diseaseLipidsLipoproteins LDLEndocrinologyCholesterolMilkTreatment OutcomechemistryLow-density lipoproteinFood FortifiedFemalelipids (amino acids peptides and proteins)Lipoprotein
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Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?

2005

Objective—Human C-reactive protein (CRP) was reported to accelerate atherosclerotic lesion development in male but not in female apolipoprotein E (apoE) knockout mice. Here, mice expressing rabbit CRP (rbCRP) were crossbred onto apoE knockout animals, and the effect on atherogenesis was studied.Methods and Results—Hemolytic complement activity could not be detected in apoE knockout mice. Furthermore, in contrast to human complement, neither rabbit nor human CRP complexed to modified low-density lipoprotein–activated murine complement. At 52 weeks, rbCRP levels were similar in male and female transgenic animals. Serum cholesterol levels were equivalent in female animals irrespective of rbCRP…

Apolipoprotein EMalemedicine.medical_specialtyPathologyRatónTransgeneHypercholesterolemiaMice TransgenicLesionMiceApolipoproteins ESpecies SpecificityInternal medicinemedicineAnimalsHumansTransgenesAortaMice KnockoutbiologyVascular diseaseC-reactive proteinCholesterol LDLComplement System Proteinsmedicine.diseaseAtherosclerosisComplement systemMice Inbred C57BLDisease Models AnimalEndocrinologyC-Reactive ProteinKnockout mousebiology.proteinFemaleDietary ProteinsRabbitsmedicine.symptomCardiology and Cardiovascular MedicineArteriosclerosis, thrombosis, and vascular biology
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Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass dist…

1999

Abstract —The effect of the expression of human hepatic lipase (HL) or human apoE on plasma lipoproteins in transgenic rabbits in response to dietary cholesterol was compared with the response of nontransgenic control rabbits. Supplementation of a chow diet with 0.3% cholesterol and 3.0% soybean oil for 10 weeks resulted in markedly increased levels of plasma cholesterol and VLDL and IDL in control rabbits as expected. Expression of either HL or apoE reduced plasma cholesterol response by 75% and 60%, respectively. The HL transgenic rabbits had substantial reductions in medium and small VLDL and IDL fractions but not in larger VLDL. LDL levels were also reduced, with a shift from larger, m…

Apolipoprotein EMalemedicine.medical_specialtyVery low-density lipoproteinTransgeneLipoproteinsCholesterol VLDLHypercholesterolemiaGene ExpressionPathogenesisAnimals Genetically ModifiedCholesterol Dietarychemistry.chemical_compoundApolipoproteins EInternal medicinemedicineAnimalsHumansTransgenesParticle SizeApolipoproteins BLagomorphabiologyCholesterolCholesterol HDLLipasebiology.organism_classificationEndocrinologyCholesterolchemistrylipoproteins apoE hepatic lipase rabbits transgeneLiverDiet Atherogeniclipids (amino acids peptides and proteins)Hepatic lipaseRabbitsCardiology and Cardiovascular MedicineLipoproteinArteriosclerosis, thrombosis, and vascular biology
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Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet.

2001

Background—On the basis of our concept that atherosclerosis has an immunopathological background, we tested whether activation of the innate immune system influences its progression.Methods and Results—Hypercholesterolemic (0.5% wt/wt diet) rabbits received either repeated intravenous injections of endotoxin (Escherichia colilipopolysaccharide 1.25 to 2.5 μg, once per week) or a self-limiting cutaneousStaphylococcus aureusinfection with or without a quinolone antibiotic. Measured laboratory parameters, including LDL and HDL cholesterols, were similar in the different groups of hypercholesterolemic animals. All endotoxin-treated animals developed transient episodes of fever after endotoxin a…

ArteriosclerosisInnate immunologyHypercholesterolemiaTriglycerides bloodPathogenesisCholesterol Dietarychemistry.chemical_compoundImmunityPhysiology (medical)MedicineAnimalsAortaTriglyceridesInnate immune systemCholesterolbusiness.industryDisease progressionCholesterol HDLCholesterol LDLImmunity InnateCholesterol bloodEndotoxinsDisease Models AnimalCholesterolchemistryImmunologyDisease ProgressionDiet AtherogenicFemaleStaphylococcal Skin InfectionsRabbitsCardiology and Cardiovascular MedicinebusinessCirculation
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