Search results for "Ley"
showing 10 items of 1218 documents
Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
2002
Metabolically formed dihydrodiol epoxides in the bay-region of polycyclic aromatic hydrocarbons are thought to be responsible for the genotoxic properties of these environmental pollutants. The hexacyclic aromatic hydrocarbon dibenzo[def,mno]chrysene (anthanthrene), although lacking this structural feature, was found to exhibit considerable bacterial mutagenicity in histidine-dependent strains TA97, TA98, TA100, and TA104 of S. typhimurium in the range of 18-40 his(+)-revertant colonies/nmol after metabolic activation with the hepatic postmitochondrial fraction of Sprague-Dawley rats treated with Aroclor 1254. This mutagenic effect amounted to 44-84% of the values determined with benzo[a]py…
Usage assignment of the residence in the cases of familiar crises: commentary on the article 6 Valencian Law of familiar relations
2015
En este trabajo se analiza la regulación valenciana respecto a la atribución del uso de la vivienda familiar, tomando en consideración las sentencias dictadas en aplicación del art. 6 de la Ley de relaciones familiares. In this paper we study the Valencian regulation with regard to the assignment of the usage of the familiar residence, taking in consideration the judgments dictated in application of the article 6 law of familiar relations.
Diurnal variation of corticotropin-releasing factor binding sites in the rat brain and pituitary.
1996
1. Corticotropin-releasing factor (CRF) is thought to be involved in the regulation of the diurnal activity of the hypothalamus-pituitary-adrenal (HPA) axis and to act as a neurotransmitter in the brain. To date it is unknown whether the binding sites of the central CRF system are subject to diurnal variations. 2. We measured the number of CRF binding sites over the course of a complete 24-hr light-dark cycle in the pituitary, amygdala, bed nucleus of the stria terminalis (BNST), cingulate cortex, visceral cortex, paraventricular nucleus of the hypothalamus, hippocampus, and locus ceruleus of rats by in vitro receptor autoradiography with iodinated ovine CRF. A 24-hr time course was also es…
Tight DNA-protein complexes isolated from barley seedlings are rich in potential guanine quadruplex sequences
2020
Background The concept of chromatin domains attached to the nuclear matrix is being revisited, with nucleus described as a set of topologically associating domains. The significance of the tightly bound to DNA proteins (TBP), a protein group that remains attached to DNA after its deproteinization should be also revisited, as the existence of these interactions is in good agreement with the concept of the topologically associating domain. The work aimed to characterize the DNA component of TBP isolated from barley seedlings. Methods The tight DNA-protein complexes from the first leaves, coleoptiles, and roots of barley seedlings were isolated by purification with chromatography on nitrocell…
Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
2013
Any change in the invariant aspects of the auditory environment is of potential importance. The human brain preattentively or automatically detects such changes. The mismatch negativity (MMN) of event-related potentials (ERPs) reflects this initial stage of auditory change detection. The origin of MMN is held to be cortical. The hippocampus is associated with a later generated P3a of ERPs reflecting involuntarily attention switches towards auditory changes that are high in magnitude. The evidence for this cortico-hippocampal dichotomy is scarce, however. To shed further light on this issue, auditory cortical and hippocampal-system (CA1, dentate gyrus, subiculum) local-field potentials were …
A cognitive architecture for inner speech
2020
Abstract A cognitive architecture for inner speech is presented. It is based on the Standard Model of Mind, integrated with modules for self-talking. Briefly, the working memory of the proposed architecture includes the phonological loop as a component which manages the exchanging information between the phonological store and the articulatory control system. The inner dialogue is modeled as a loop where the phonological store hears the inner voice produced by the hidden articulator process. A central executive module drives the whole system, and contributes to the generation of conscious thoughts by retrieving information from long-term memory. The surface form of thoughts thus emerges by …
Patsy Healey and Collaborative Planning (2005): Re-thinking Democracy in the ‘Reasoning in Public’ Arena
2022
The interpretation of the notion of citizenship has led some authors to the conclusion of the necessity of overcoming a ‘restricted conception’ of citizenship, in order to gain a more inclusive recognition of a cosmopolitan, rather than a mere universal, recognition of rights. So, three core issues are tightly intertwined in this paper: the controversial issue of citizenship in its multiple facets: the formal that is institutional, the substantial and the denied one; the role of planning and its ethical implications; and the very idea of democracy in its dichotomy: institutional versus substantial. Patsy Healey’s work offers us a wide set of normative perspectives and intellectual stimuli, …
Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise.
2003
Glucocorticoids have anti-anabolic effects on many tissues and can cause muscle atrophy. However, their effects on type IV collagen gene expression and degradation in skeletal muscle have not been studied previously. Rats were treated daily with dexamethasone or saline. Half the groups of experimental and control animals were also subjected to daily endurance or uphill running exercise to determine the possible preventive effects of exercise. After an experimental period of 3 or 10 days, the extensor digitorum longus, soleus and tibialis anterior muscles were studied. Dexamethasone treatment for 10 days reduced muscle weight and type IV collagen mRNA abundance in all muscles. Gene expressio…
Bayesian hypothesis testing: A reference approach
2002
Summary For any probability model M={p(x|θ, ω), θeΘ, ωeΩ} assumed to describe the probabilistic behaviour of data xeX, it is argued that testing whether or not the available data are compatible with the hypothesis H0={θ=θ0} is best considered as a formal decision problem on whether to use (a0), or not to use (a0), the simpler probability model (or null model) M0={p(x|θ0, ω), ωeΩ}, where the loss difference L(a0, θ, ω) –L(a0, θ, ω) is proportional to the amount of information δ(θ0, ω), which would be lost if the simplified model M0 were used as a proxy for the assumed model M. For any prior distribution π(θ, ω), the appropriate normative solution is obtained by rejecting the null model M0 wh…
A Group-theoretical Finiteness Theorem
2008
We start with the universal covering space $${\*M^n}$$ of a closed n-manifold and with a tree of fundamental domains which zips it $${T\longrightarrow\*M^n}$$ . Our result is that, between T and $${\* M^n}$$ , is an intermediary object, $${T\stackrel{p} {\longrightarrow} G \stackrel{F}{\longrightarrow} \*M^n}$$ , obtained by zipping, such that each fiber of p is finite and $${T\stackrel{p}{\longrightarrow}G\stackrel{F}{\longrightarrow} \*M^n}$$ admits a section.