Search results for "Ley"
showing 10 items of 1218 documents
Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John’s Wort
2004
Abstract Extracts of the medicinal plant St. John’s Wort ( Hypericum perforatum ) are widely used in the therapy of affective disorders and have been reported to exert antidepressant, anxiolytic, and cognitive effects in experimental and clinical studies. We here report that hyperforin, the major active constituent of the extract, increases the release of acetylcholine from rat hippocampus in vivo as determined by microdialysis. Hippocampal acetylcholine levels were increased by 50–100% following the systemic administration of pure hyperforin at doses of 1 and 10 mg/kg. The effect was almost completely suppressed by local perfusion with calcium-free buffer or with tetrodotoxin (1 μM). We co…
Redistribution of tax resources: a cooperative game theory approach
2021
AbstractWe consider the problem of how to distribute public expenditure among the different regions of an economic entity after all taxes have been collected. Typical examples are: the regions that make up a country, the states of a federal country, or the countries of a confederation of countries. We model the problem as a cooperative game in coalitional form, called the tax game. This game estimates the fiscal resources collected in each region, or coalition of regions, by differentiating between what comes from economic activity within each region and what comes from trade with the other regions. This methodology provides a measure of the disagreement within a region, or coalitions of re…
Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: effects…
2012
The medical use of nitroglycerin (GTN) is limited by patient tolerance. The present study evaluated the role of mitochondrial Complex I in GIN biotransformation and the therapeutic effect of mitochondrial antioxidants. The development of GIN tolerance (in rat and human vessels) produced a decrease in mitochondrial 02 consumption. Co-incubation with the mitochondria-targeted antioxidant mitoquinone (MQ 10(-6) mol/L) or with glutathione ester (GEE, 10(-4) mol/L) blocked GTN tolerance and the effects of GTN on mitochondrial respiration and aldehyde dehydrogenase 2 (ALDH-2) activity. Biotransformation of GTN depended on the mitochondria being functionally active, particularly mitochondrial Comp…
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damag…
2009
An unusual class of 5,6,7-trioxygenated dihydroflavonols (3a-e and 4a-j) were designed and prepared. Their antioxidative properties were assessed by examining their capacities in several in vitro models, including superoxide anion and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, rat liver homogenate lipid peroxidation inhibition, PC12 cells protection from oxidative damage, and xanthine oxidase inhibition. These dihydroflavonols displayed positive quenching abilities towards O(2)(-) and DPPH free radicals, in which the majority exhibited superior antioxidant properties to Vitamin C. cis-Configurated compound (+/-)-3e demonstrated remarkable inhibition to LPO with an IC(50) value…
The General Education Act of 1970, a law for the modernization of Spain
2021
El artículo pretende desarrollar aspectos que ayuden a una mejor comprensión de la Ley General de Educación de 1970, y para ello examina los factores que permiten hablar de una Ley para la modernización de España. En este sentido se ha considerado que el rasgo más definitorio de la Ley es su ambición modernizadora del sistema educativo; de ahí que se concrete el concepto «modernización» y se estudien los precedentes y los ejes modernizadores de la Ley. También se ha prestado atención al contexto socioeconómico y político que ayuda a entender mejor su aparición. Dada su importancia, el artículo se detiene en analizar los obstáculos y resistencias que dificultaron su génesis y su aplicación, …
Effects of zoledronic acid and dexamethasone on early phases of socket healing after tooth extraction in rats : a preliminary macroscopic and microsc…
2018
Background The exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is still unknown. The aim of this paper was to investigate the effects of zoledronic acid and dexamethasone on the early phases of socket healing in rats subjected to tooth extractions. Material and Methods Thirty male Sprague-Dawley rats were divided into 2 groups: pharmacologically treated group (T, n=20) and non-pharmacologically treated group (C, n=10). T group rats received 0.1 mg/Kg of zoledronic acid (ZOL) and 1 mg/Kg of dexamethasone (DEX) three times a week for 10 consecutive weeks. C group rats were infused with vehicle. After 9 weeks from the first infusion, first maxillary molars were extrac…
Intraseasonal variations of June?September rainfall and upper-air circulation over Kenya
1996
In the Northern Summer, Kenya is located under the influence of the divergent Indian monsoon flow, and therefore is dry except for two separate areas: the coastal strip and the western regions. Analysis of daily rainfall data for June–September 1982 to 1988 has revealed that, although there are many distinct rainfall events between the two regions, an out-of-phase relationship is also evident, rain on the Coast being frequently accompanied by a drop in the precipitation over the Rift Valley area. It is shown that two types of wind forcing accompany these patterns. Alternating westerly and easterly anomalies at the 700 hPa level are associated with persistent wet and dry conditions (respecti…
A pragmatic study of nonsense, from Lewis Carroll to the Monty Python
2010
This dissertation consists in a study of verbal exchanges in nonsense literature, from the last quarter of the nineteenth century and one of the two fathers of the genre, Lewis Carroll, to the last quarter of the twentieth century and his glorious heirs, the Monty Python. The corpus is taken from the whole of English-speaking nonsense literature, be it English (Lewis Carroll, the Monty Python, N.F. Simpson), Canadian (Stephen Leacock), or American (Robert Benchley, Donald Ogden Stewart, Joseph Heller and the Marx Brothers). As the title indicates, the study of verbal exchanges will rely on pragmatic analysis, pragmatics being the study of how language works as a practice, in social context.…
Characterisation of Physical and Biochemical Traits of Hulless Spring Barley Grain in the Latvian Breeding Programme
2013
Abstract Incorporation of whole grain, such as hulless barley, as a part of a balanced diet can help reduce the risk of coronary heart diseases, diabetes and specific cancers, and provide other health benefits as well. The objectives of this study were to determine the physical and chemical characteristics of grains of hulless barley genotypes from the Latvian spring barley programme. Field experiments were carried out in 2010-2011 at the State Stende Cereal Breeding Institute. Grain samples of 29 hulless spring barley breeding lines were analysed for grain physical traits (1000 kernel weight, test weight), macronutrients (crude protein, starch, β -glucans), and micronutrients (total phenol…
Costanti e metamorfosi di un mito. Beatrice Cenci nell'Ottocento, da Shelley a Guerrazzi e oltre.
2011
Il saggio ripercorre la trasformazione in mito letterario della storia di Beatrice Cenci, le la sua straordinaria fortuna nel romanzo e nel teatro europei, con riferimento particolare alla sua presa sulla sensibilità romantica e inoltre al suo ruolo nell'immaginario risorgimentale. The essay deals with the transformation of Beatrice Cenci’ story in a literary myth, with special reference to its impact on the romantic sensitivity, on the collective imagination of Italian Risorgimento, and in the works by Shelley, Stendhal, Dumas and Guerrazzi,