Search results for "Liber"
showing 10 items of 1718 documents
Controlling the semi-permeability of protein nanocapsules influences the cellular response to macromolecular payloads.
2021
Nanocapsules are an excellent platform for the delivery of macromolecular payloads such as proteins, nucleic acids or polyprodrugs, since they can both protect the sensitive cargo and target its delivery to the desired site of action. However, the release of macromolecules from nanocapsules remains a challenge due to their restricted diffusion through the nanoshell compared to small molecule cargo. Here, we designed degradable protein nanocapsules with varying crosslinking densities of the nanoshell to control the release of model macromolecules. While the crosslinking did not influence the degradability of the capsules by natural proteases, it significantly affected the release profiles. F…
Le difficoltà probatorie per superare il ragionevole dubbio nei processi di criminalità organizzata
2022
Analisi diacronica delle problematiche probatorie più rilevanti nei procedimenti per "fatti di mafia" con proiezioni sul convincimento del giudice e sul contraddittorio probatorio. Il preteso ruolo normante della giurisprudenza viene posto a raffronto con frizioni dogmatiche e ricadute operative dimostrando la fragilità degli accertamenti in tema di indicatori della partecipazione alla associazione, della base indiziaria e della "messa a disposizione".
Polyanion–tobramycin nanocomplexes into functional microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
2016
Aim: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new ‘nano-into-micro’ approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier. Methods: Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus. Results & discussion: MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in Pseudomonas aeruginosa infections if compared with free tobramycin. Co…
Negative Platonism and Maximal Existence in the Thought of Jan Patocka
2010
According to Jan Patocka’s “negative Platonism,” ordinary, or “positive” Platonism makes a fundamental mistake in formulating Plato’s true “discovery,” i.e., the Idea, as a non-objective determination of objectivity, in terms of an ideal object that sensible objects are supposed to imitate. Does this mean that Plato himself misunderstood the epimeleia tēs psychēs and human self-knowledge (exetasis)? Analogously, Patocka states that “classical phenomenology fell victim to its own discoveries and their imprecise formulation.” Is this due to the transcendental subjectivism of Husserlian thought or, rather, to the fact that Husserl could theorize only the modes of givenness of an object? These …
Conceptualizing and Measuring the Quality of Democracy: The Citizens' Perspective
2018
In recent years, several measurements of the quality of democracy have been developed (e.g. Democracy Barometer, Varieties of Democracy Project). These objective measurements focus on institutional and procedural characteristics of democracy. This article starts from the premise that in order to fully understand the quality of democracy such objective measurements have to be complemented by subjective measurements based on the perspective of citizens. The aim of the article is to conceptualize and measure the subjective quality of democracy. First, a conceptualization of the subjective quality of democracy is developed consisting of citizens’ support for three normative models of democracy …
Istigazione punibile e libertà di parola. Riflessioni in margine alla sentenza De Luca
2016
Il testo prende spunto dalla decisione del Tribunale di Torino, che ha riguardato il noto scrittore Erri De Luca, per chiarire e mettere a punto alcuni profili della teoria dell’istigazione a delinquere e i rapporti di questa con la libertà d’espressione. By commenting on the decision given by the Tribunal of Turin in the case of the renowned writer Erri De Luca, the paper clarifies some controversial aspects of the criminalization of the conduct of public encouragement to crime, as well as its relationships with the right to free speech.
Dígalo sin muertos
2003
Yves Montand : la emoción de la memoria
1981
Enlightened paternalism: the prohibition of corporal punishment in Spanish public schools in the nineteenth century
2014
In order to analyse the cultural values of Spanish liberalism, this paper describes the prohibition of corporal punishment in secondary education. The evolution of education laws and codes during the nineteenth century reveals great hope and confidence in building up an academic authority based exclusively on the power of reason and capable of ruling an ordered society. However, the study of documents found in the Instituto de Valencia historical archives highlights the difficulty of maintaining discipline as well as managing the political motivations of rebellious students, who demanded more autonomy from the academic authority.
Los bienes comunes como aproximación materialista al problema del bien común: una réplica a Ermanno Vitale
2021
Este artículo pretende ser una réplica a alguno de los planteamientos críticos que ha desarrollado Ermanno Vitale contra las teorías de los bienes comunes, especialmente contra las teorías benecomunistas que han florecido en el debate político y académico italiano. En particular, pretende responder a una conferencia pronunciada por el filósofo italiano en diciembre de 2020 –cuyo texto se reproduce en este mismo número de la revista–, en la que propuso rechazar las doctrinas de los comunes, en favor de la clásica noción del bien común. Aquí se sostendrá que, en realidad, las teorías de los comunes constituyen la única estrategia interesante para replantear el concepto de bien común en la act…