Search results for "Libraries"

Contribution of phase-mixing of Alfvén waves to coronal heating in multi-harmonic loop oscillations

2018

This research has received funding from the Science and Technology Facilities Council (UK) through the consolidated grant ST/N000609/1 and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program ( grant agreement No. 647214). This work is supported by the European Research Council under the SeismoSun Research Project No. 321141 (DJP). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 724326). This work used the DiRAC Data Centric system at Durham University, operated by the Institute for Computational Cosmology on behalf o…

Deformed quons and bi-coherent states

2017

We discuss how a q-mutation relation can be deformed replacing a pair of conjugate operators with two other and unrelated operators, as it is done in the construction of pseudo-fermions, pseudo-bosons and truncated pseudo-bosons. This deformation involves interesting mathematical problems and suggests possible applications to pseudo-hermitian quantum mechanics. We construct bi-coherent states associated to $\D$-pseudo-quons, and we show that they share many of their properties with ordinary coherent states. In particular, we find conditions for these states to exist, to be eigenstates of suitable annihilation operators and to give rise to a resolution of the identity. Two examples are discu…

"Tea for two": the Archive of the Italian Latinity of the Middle Ages meets the CLARIN infrastructure

2020

This paper aims at showing how integrating the Archive of the Italian Latinity of the Middle Ages (ALIM) into the ILC4CLARIN repository can provide mutual benefits. Making ALIM available to a large community of scholars and researchers, on the one side, represents the first step to reduce the lack of resources for Medieval Latin in CLARIN and, on the other side, constitutes an unprecedented contribution to not only linguistic investigations, but also to the studies of the culture and science at the basis of the Western European society. The paper describes the adopted approach aiming to keep intact the structure of the archive and its metadata, which are both accurately mirrored into the IL…

Einstein's Washington Manuscript on Unified Field Theory

2020

In this note, we point attention to and briefly discuss a curious manuscript of Einstein, composed in 1938 and entitled "Unified Field Theory," the only such writing, published or unpublished, carrying this title without any further specification. Apparently never intended for publication, the manuscript sheds light both on Einstein's modus operandi as well as on the public role of Einstein's later work on a unified field theory of gravitation and electromagnetism.

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity

2017

Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells …

Magnetic fields in heavy ion collisions: flow and charge transport

2020

At the earliest times after a heavy-ion collision, the magnetic field created by the spectator nucleons will generate an extremely strong, albeit rapidly decreasing in time, magnetic field. The impact of this magnetic field may have detectable consequences, and is believed to drive anomalous transport effects like the Chiral Magnetic Effect (CME). We detail an exploratory study on the effects of a dynamical magnetic field on the hydrodynamic medium created in the collisions of two ultrarelativistic heavy-ions, using the framework of numerical ideal MagnetoHydroDynamics (MHD) with the ECHO-QGP code. In this study, we consider a magnetic field captured in a conducting medium, where the conduc…

TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro

2017

International audience; The quest for chemicals able to operate at selected genomic loci in a spatiotemporally controlled manner is desirable to create manageable DNA damages. Mounting evidence now shows that alternative DNA structures, including G-quadruplexes and branched DNA (or DNA junctions), might hamper proper progression of replication fork, thus triggering DNA damages and genomic instability. Therefore, small molecules that stabilize these DNA structures are currently scrutinized as a promising way to create genomic defects that cannot be dealt with properly by cancer cells. While much emphasis has been recently given to G-quadruplexes and related ligands, we report herein on three…

2013

Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points for drug discovery. However, the discovery and development of novel inhibitors remains challenging. Here, we describe a structure-based de novo design approach that generates novel, hinge-binding fragments that are synthetically feasible and can be elaborated to small molecule libraries. Starting from commercially available compounds, core fragments were extracted, filtered for pharmacophoric properties compatible w…

Weak pion production off the nucleon in covariant chiral perturbation theory

2018

Weak pion production off the nucleon at low energies has been systematically investigated in manifestly relativistic baryon chiral perturbation theory with explicit inclusion of the $\Delta$(1232) resonance. Most of the involved low-energy constants have been previously determined in other processes such as pion-nucleon elastic scattering and electromagnetic pion production off the nucleon. For numerical estimates, the few remaining constants are set to be of natural size. As a result, the total cross sections for single pion production on neutrons and protons, induced either by neutrino or antineutrino, are predicted. Our results are consistent with the scarce existing experimental data ex…

Identification of estrogen receptor α ligands with virtual screening techniques.

2016

Utilization of computer-aided molecular discovery methods in virtual screening (VS) is a cost-effective approach to identify novel bioactive small molecules. Unfortunately, no universal VS strategy can guarantee high hit rates for all biological targets, but each target requires distinct, fine-tuned solutions. Here, we have studied in retrospective manner the effectiveness and usefulness of common pharmacophore hypothesis, molecular docking and negative image-based screening as potential VS tools for a widely applied drug discovery target, estrogen receptor α (ERα). The comparison of the methods helps to demonstrate the differences in their ability to identify active molecules. For example,…