Search results for "Library and Information Science"
showing 10 items of 1965 documents
Customer’s role in knowledge management and in the innovation process: effects on innovation capacity and marketing results
2016
Scholars have acknowledged customer knowledge management (CKM) as a key strategic resource for improving innovation and supporting long-term customer relationship management. This study provides a deeper understanding of the internal antecedents of business innovation capacity overcoming previous approaches. A model that had not previously been tested was used to analyse the role of customer collaboration and CKM – measured as a second-order construct – in innovation processes and marketing results. To test the model, structural equation modelling (partial least squares) was applied to a random sample of 210 Spanish companies. Results confirm that CKM and customer collaboration are antecede…
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme.
2019
Phosphorylation by kinases enzymes is a widespread regulatory mechanism able of rapidly altering the function of target proteins. Among these are cytochrome P450s (CYP450), a superfamily of enzymes performing the oxidation of endogenous and exogenous substrates thanks to the electron supply of a redox partner. In spite of its pivotal role, the molecular mechanism by which phosphorylation modulates CYP450s metabolism remains elusive. Here by performing microsecond-long all-atom molecular dynamics simulations, we disclose how phosphorylation regulates estrogen biosynthesis, catalyzed by the Human Aromatase (HA) enzyme. Namely, we unprecedentedly propose that HA phosphorylation at Y361 markedl…
Effet de l'orientation des fibres des plis adjacents sur la résistance au délaminage en mode I pur = Effect of the fibre's orientation of adjacent pl…
2009
National audience; Ce travail concerne l'étude de l'effet de l'orientation des fibres des plis adjacents à la fissure dans une éprouvette DCB (Double Cantilever Beam) sur la résistance au délaminage en mode I pur. Afin d'isoler l'influence de l'orientation l'étude porte sur des stratifiés particuliers ayant tous les mêmes matrices de comportement global A B D. Les résultats expérimentaux montrent une grande variation de résistance au délaminage GIC et des courbes R selon l'orientation des plis situés de part et d'autre du plan de fissure. Une modélisation par éléments finis permet de mettre en évidence l'importance de l'état de contraintes locales et donc de l'endommagement au voisinage du …
Information territoriale : une construction collective nécessaire
2011
Les récents événements sociaux observés au niveau mondial, des crises financières et économiques à la crise sociale actuelle, poussent à imaginer de nouveaux modes de conception d'une organisation territoriale revisitée. Il semble inopportun dans le contexte actuel de continuer à vouloir structurer des sociétés selon des schémas verticaux (du haut vers le bas, du bas vers le haut) sans une réelle co-construction d'une vision concertée des enjeux comme des besoins sociaux. Décréter la participation citoyenne ne suffit pas ; l'appropriation d'une vision prospective s'avère parcellaire car encore inscrite dans une expression extra-territoriale dominante et surtout dans un schéma autoritaire. L…
Latvijas Universitātes Bibliotēkas jaunumi, 2015
2015
Mana pieredze jeb gads digitalizācijā
2017
Rakstā izklāstīta LU Bibliotēkas darbinieces digitalizācijas darba pieredze.
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties
2021
Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ec…
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
2014
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment …
Assembly support systems with Markov predictors
2020
In this paper, we analyse Markov prediction as a suitable model to suggest the next assembly step in the manufacturing process. The goal is a decision support system which can assist the workers in...