Search results for "Library"

Internationales Komplement Symposion 14. und 15. Juli 1969 in Mainz

1969

Consensus document on controversial issues for the treatment of hospital-associated pneumonia

2010

Background: Hospital-associated pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. Many aspects of the treatment of HAP caused by multi-resistant Gram-positive microorganisms have been extensively studied, but controversial issues remain. Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group – a panel of multidisciplinary experts – was to define recommendations for some controversial issues using an evidence-based and analytical approach. The controversial issues were: (1) Is combination antibiotic therapy or monotherapy more effective in the treatment of HAP? (2) What role do…

Mineral trioxide aggregate in primary teeth pulpotomy. A systematic literature review

2009

Evidence-based dentistry is a critical evaluation, awareness of the available evidence to improve decision making about the care of individual patients and / or communities. Objective: To systematically analyze the available scientific literature on clinical and radiographic results of two materials used in pulpotomy in primary teeth: formocresol and mineral trioxide aggregate. Materials and methods: It was identified relevant publications through a search of electronic databases such as MEDLINE (Ovid) and The Cochrane Library. To be included in the review, studies had to define the material used in child patients with pulp exposure by caries or tooth-alveolar trauma. Results: Of the 21 art…

Le fonds d’archives de l’enquête sur Minot, Bourgogne

2014

International audience

Search in Texts! Misiņš Library, Kārlis Egle 130

2018

Injecting disinformation into public space: pseudo-media and reality-altering narratives

2022

This paper analyses the context of disinformation in Spain from the perspective of the pseudo-media (i.e., websites that mimic conventional media to offer partisan content based on alternative facts). Using a quantitative (N = 1,143) and qualitative (n = 396) methodology, this research analyses publications from eight Spanish pseudo-media that reach more than 4 million unique users. Results reveal an interest in three topics: vaccination, restrictions and speculation about Covid-19, national politics –focused on criticism against government– and topics related to human rights –mainly LGBTI, gender, immigration– with a total of 58.1% of the content published in four sections (International, …

Posverdad, o la narración del procés catalán desde el exterior: BBC, DW y RT

2019

Con el procés independentista de Cataluña como marco, compararemos el tratamiento periodístico que recibe el fenómeno en tres medios de comunicación extranjeros, reflejado en su difusión a través de la red social Facebook. BBC, DW y RT son corporaciones financiadas públicamente por gobiernos ajenos a priori a la problemática social y política generada sobre el debate separatista. Aun así, uno de ellos, RT, ha sido acusado públicamente de actuar directamente bajo la influencia de las directrices de política exterior del Kremlin, y de cometer injerencias a favor de los independentistas. Desde una perspectiva cuantitativa y cualitativa, analizamos los posts difundidos por estos medios durante …

Digitalis purpurea P5 beta R2, encoding steroid 5 beta-reductase, is a novel defense-related gene involved in cardenolide biosynthesis.

2009

The stereospecific 5 beta-reduction of progesterone is a required step for cardiac glycoside biosynthesis in foxglove plants. Recently, we have isolated the gene P5 beta R, and here we investigate the function and regulation of P5 beta R2, a new progesterone 5 beta-reductase gene from Digitalis purpurea. P5 beta R2 cDNA was isolated from a D. purpurea cDNA library and further characterized at the biochemical, structural and physiological levels. Like P5 beta R, P5 beta R2 catalyzes the 5 beta-reduction of the Delta(4) double bond of several steroids and is present in all plant organs. Under stress conditions or on treatment with chemical elicitors, P5 beta R expression does not vary, wherea…

Molecular dissection of human Argonaute proteins by DNA shuffling.

2013

A paramount task in RNA interference research is to decipher the complex biology of cellular effectors, exemplified in humans by four pleiotropic Argonaute proteins (Ago1-Ago4). Here, we exploited DNA family shuffling, a molecular evolution technology, to generate chimeric Ago protein libraries for dissection of intricate phenotypes independently of prior structural knowledge. Through shuffling of human Ago2 and Ago3, we discovered two N-terminal motifs that govern RNA cleavage in concert with the PIWI domain. Structural modeling predicts an impact on protein rigidity and/or RNA-PIWI alignment, suggesting new mechanistic explanations for Ago3's slicing deficiency. Characterization of hybrid…

Temperature-controlled release by changes in the secondary structure of peptides anchored onto mesoporous silica supports

2014

Changes in the conformation of a peptide anchored onto the external surface of mesoporous silica nanoparticles have been used to design novel temperature-controlled delivery systems.