Search results for "Libration"

Nanoprobing the acidification process during intracellular uptake and trafficking

2015

Abstract Many nanoparticular drug delivery approaches rely on a detailed knowledge of the acidification process during intracellular trafficking of endocytosed nanoparticles (NPs). Therefore we produced a nanoparticular pH sensor composed of the fluorescent pH-sensitive dual wavelength dye carboxy seminaphthorhodafluor-1 (carboxy SNARF-1) coupled to the surface of amino-functionalized polystyrene NPs (SNARF-1-NP). By applying a calibration fit function to confocal laser scanning microscopy (CLSM) images, local pH values were determined. The acidification and ripening process of endo/lysosomal compartments containing nanoparticles was followed over time and was found to progress up to 6h to …

INTEGRAL/RXTE Observations of Cygnus X-1

2003

We present first results from contemporaneous observations of Cygnus X-1 with INTEGRAL and RXTE, made during INTEGRAL's performance verification phase in 2002 November and December. Consistent with earlier results, the 3-250 keV data are well described by Comptonization spectra from a Compton corona with a temperature of kT~50-90 keV and an optical depth of tau~1.0-1.3 plus reflection from a cold or mildly ionized slab with a covering factor of Omega/2pi~0.2-0.3. A soft excess below 10 keV, interpreted as emission from the accretion disk, is seen to decrease during the 1.5 months spanned by our observations. Our results indicate a remarkable consistency among the independently calibrated de…

A Multiple Local Models Approach to Accuracy Improvement in Continuous Glucose Monitoring

2011

Continuous glucose monitoring (CGM) devices estimate plasma glucose (PG) from measurements in compartments alternative to blood. The accuracy of currently available CGM is yet unsatisfactory and may depend on the implemented calibration algorithms, which do not compensate adequately for the differences of glucose dynamics between the compartments. Here we propose and validate an innovative calibration algorithm for the improvement of CGM performance.CGM data from GlucoDay(®) (A. Menarini, Florence, Italy) and paired reference PG have been obtained from eight subjects without diabetes during eu-, hypo-, and hyperglycemic hyperinsulinemic clamps. A calibration algorithm based on a dynamic glo…

Polydimethylsiloxane (silicone rubber) brooch as a personal passive air sampler for semi-volatile organic compounds

2018

Exposure assessments conducted using a personal sampler include the contribution of human activities to exposure that is neglected when using a stationary air sampler. This study evaluated the uptake characteristics and application of the polydimethylsiloxane (PDMS or silicone rubber) brooch as a personal passive air sampler (PPAS) for measuring concentrations of two groups of semi-volatile organic compounds (SVOCs), namely phthalates and organophosphate esters (OPEs), indoors in proximity to the breathing zone. Uptake rates of the PDMS brooch were calibrated against a personal low volume active air sampler (PLV-AAS) co-deployed on each of five study participants working in offices for 8 hs…

Roughness and vegetation parameterizations at L-band for soil moisture retrievals over a vineyard field

2015

Abstract The capability of L-band radiometry to monitor surface soil moisture (SM) at global scale has been analyzed in numerous studies, mostly in the framework of the ESA SMOS and NASA SMAP missions. To retrieve SM from L-band radiometric observations, two significant effects have to be accounted for, namely soil roughness and vegetation optical depth. In this study, soil roughness effects on retrieved SM values were evaluated using brightness temperatures acquired by the L-band ELBARA-II radiometer, over a vineyard field at the Valencia Anchor Station (VAS) site during the year 2013. Different combinations of the values of the model parameters used to account for soil roughness effects (…

Improving sensitivity in simultaneous determination of copper carboxylates by nonaqueous capillary electrophoresis

2005

Abstract A new method of nonaqueous capillary electrophoresis (NACE) with UV spectrophotometric detection was developed and optimized for the simultaneous determination of seven carboxylates (trans-1,2-diaminocyclohexane-N,N,N′,N′-tetraacetic acid (CDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminetetraacetic acid (EDTA), N-(2-hydroxyethyl)ethylenediamine-N,N′,N′-triacetic acid (HEDTA), nitrilotriacetic acid (NTA), 1,3-diaminopropane-N,N,N′,N′-tetraacetic acid (PDTA) and triethylenetetraaminehexaacetic acid (TTHA)) as copper complexes. The method development was carried out by using a fused silica capillary. Background electrolyte (BGE) was optimized and the best separation a…

Three-Dimensional Calibration for Routine Analyses of Bromide and Nitrate Ions as Indicators of Groundwater Quality in Coastal Territories

2019

Nitrate and bromide ions are generally considered indicators of anthropogenic pollution and seawater intrusion, respectively, in the groundwater of coastal territories. The analysis of these species is generally carried out with routine chromatographic analyses which generally afford partially merged or poorly resolved peaks. In the present paper a simple method for the correct evaluation of their concentration in water is reported. This method does not imply utilization of other instruments or technologies, only the mathematical elaboration of the data obtained from routine analysis of standard solutions containing the two species. Standard binary solutions of nitrate and bromide ions at d…

MILES extended: Stellar population synthesis models from the optical to the infrared

2016

We present the first single-burst stellar population models which covers the optical and the infrared wavelength range between 3500 and 50000 Angstrom and which are exclusively based on empirical stellar spectra. To obtain these joint models, we combined the extended MILES models in the optical with our new infrared models that are based on the IRTF (Infrared Telescope Facility) library. The latter are available only for a limited range in terms of both age and metallicity. Our combined single-burst stellar population models were calculated for ages larger than 1 Gyr, for metallicities between [Fe/H] = -0.40 and 0.26, for initial mass functions of various types and slopes, and on the basis …

Leaks Analysis in Pipeline Systems by Means of Optimal valve Regulation

1999

Experimental and DFT studies on competitive heterocyclic rearrangements. part 2: A one-atom side-chain versus the classic three-atom side-chain (Boul…

2007

The experimental investigation of the base-catalyzed rearrangements of 3-acylamino-1,2,4-oxadiazoles evidenced a new reaction pathway which competes with the well-known ring-degenerate Boulton- Katritzky rearrangement (BKR). The new reaction consists of a one-atom side-chain rearrangement that is base-activated, occurs at a higher temperature than the BKR, and irreversibly leads to the corresponding 2-acylamino-1,3,4-oxadiazoles. An extensive DFT study is reported to elucidate the proposed reaction mechanism and to compare the three possible inherent routes: (i) the reversible three-atom side-chain ring-degenerate BKR, (ii) the ring contraction-ring expansion route (RCRE), and (iii) the one…