Search results for "Libri"
showing 10 items of 1189 documents
Biosensor-based kinetic and thermodynamic characterization of opioids interaction with human μ-opioid receptor.
2019
Development of opioid analgesics with minimal side effects requires substantial knowledge on structure-kinetic and -thermodynamic relationship of opioid-receptor interactions. Here, combined kinetics and thermodynamics of opioid agonist binding to human μ-opioid receptor (h-μOR) was investigated using real-time label-free surface plasmon resonance (SPR)-based method. The N-terminal end truncated and C-terminal 6His-tagged h-μOR was constructed and expressed in E. coli. Receptor was purified, detergent-solubilized and characterized by circular dichroism. The uniform immobilization of h-μOR on Ni-NTA chips was achieved using hybrid capture-coupling approach followed by reconstitution in lipid…
Disorder and interactions in systems out of equilibrium : the exact independent-particle picture from density functional theory
2017
Density functional theory (DFT) exploits an independent-particle-system construction to replicate the densities and current of an interacting system. This construction is used here to access the exact effective potential and bias of non-equilibrium systems with disorder and interactions. Our results show that interactions smoothen the effective disorder landscape, but do not necessarily increase the current, due to the competition of disorder screening and effective bias. This puts forward DFT as a diagnostic tool to understand disorder screening in a wide class of interacting disordered systems.
Producer's spatial equilibrium with a fuzzy constraint
1980
The classical theory of the producer’s equilibrium rests on two sets of particularly restrictive hypotheses. First it is implicitely assumed that all inputs and outputs are located in a single place where the producer is also implanted and where the production is carried out. Next it is assumed that the producer follows a precise behaviour pattern, by this we mean that the producer has complete information concerning the conditions of hisproductive activity and he has perfect command over both the set of inputs and the set of outputs; he realises the maximum profit allowed by the technological constraint which limits his possible actions and by the given price system. The aim of this study …
Control of kinetics by cooperative interactions.
2011
Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity as found in oxygen binding proteins, a typical property is an autocatalytic ligand dissociation behavior leading to a time dependent, apparent ligand dissociation rate. To follow systematically the influence of the various potentially involved parameters on this characteristic property, simulations based on the simple MWC model were performed which should be relevant for all ty…
Periodic Solutions of the Second Order Quadratic Rational Difference Equation $$x_{n+1}=\frac{\alpha }{(1+x_n)x_{n-1}} $$ x n + 1 = α ( 1 + x n ) x n…
2016
The aim of this article is to investigate the periodic nature of solutions of a rational difference equation $$x_{n+1}=\frac{\alpha }{(1+x_n)x_{n-1}}. {(*)} $$ We explore Open Problem 3.3 given in Amleh et al. (Int J Differ Equ 3(1):1–35, 2008, [2]) that requires to determine all periodic solutions of the equation (*). We conclude that for the equation (*) there are no periodic solution with prime period 3 and 4. Period 7 is first period for which exists nonnegative parameter \(\alpha \) and nonnegative initial conditions.
On Capturing Rent from a Non-Renewable Resource International Monopoly: A Dynamic Game Approach
2005
In this paper we model the case of an international non-renewable resource monopolist as a dynamic game between a monopolist and n importing countries governments, and we investigate whether a tariff on resource imports can be advantageous for the consumers of the importing countries when the monopolist sets the price and the importing countries governments act in a non-cooperative way. We find that a tariff is advantageous for the consumers even when there is not commitment to the trade policy although the part of the rent that can be reaped by the importing countries decreases substantially with the number of importing countries. The optimality of the tariff in our dynamic game is explain…
Phytoplankton equilibrium phases during thermal stratification in a deep subtropical reservoir
2008
SUMMARY 1. Equilibrium and non-equilibrium hypotheses have often been used to explain observations in community ecology. Published case studies have demonstrated that steady state phytoplankton assemblages are more likely to occur in deep lakes than in shallow mixed ones. 2. Phytoplankton seasonal succession was studied by weekly sampling in Faxinal Reservoir (S Brazil), a subtropical deep, clear, warm monomictic and slightly eutrophic reservoir. This study demonstrated an alternation of steady and non-steady state phases of phytoplankton assemblages with different dominant species during the steady states. 3. During the studied period, three steady states were identified with different dom…
Thermal solitons in nanotubes
2022
Starting from a recent proposal of a nonlinear Maxwell-Cattaneo equation for the heat transport with relaxational effects at nanoscale, in a special case of thermal-wave propagation we derive a nonlinear Schrodinger equation for the amplitudes of the heatflux perturbation. The complete integrability of the obtained equation is investigated in order to prove the existence of infinite conservation laws, as well as the existence of infinite exact solutions. In this regards, we have considered the simplest nontrivial solutions, namely, the bright and dark (thermal) solitons, which may be interesting for energy transport and for information transmission in phononic circuits. (c) 2022 Elsevier B.…
Efecto de un protocolo de fisioterapia para la recuperación del equilibrio y la marcha tras ictus en personas mayores basado en criterios clínico-fun…
2016
El ictus es una de las principales causas de discapacidad en todo el mundo. La edad se considera el marcador de riesgo más importante ya que aumenta exponencialmente su incidencia. La investigación futura debe esclarecer qué técnicas fisioterápicas específicas son más adecuadas para la recuperación funcional tras ictus. El objetivo de esta tesis doctoral fue estudiar el efecto de un protocolo de intervención fisioterápica basado en criterios clínico-funcionales junto con técnicas específicas de estimulación de la planta del pie parético, disociación del movimiento y entrenamiento del equilibrio en la recuperación funcional de las personas mayores con hemiplejia tras ictus en las fases aguda…
The Economic Impact of the South-North Water Transfer Project in China: A Computable General Equilibrium Analysis
2006
Water resources are unevenly spread in China. Especially the basins of the Yellow, Hui and Hai rivers in the North are rather dry. To increase the supply of water in these basins, the South-to-North Water Transfer project (SNWT) was launched. Using a computable general equilibrium model this study estimates the impact of the project on the economy of China and the rest of the world. We contrast three alternative groups of scenarios. All are directly concerned with the South-to-North water transfer project to increase water supply. In the first group of scenarios additional supply implies productivity gains. We call it the “non-market” solution. The second group of scenarios is called “marke…