Search results for "Life cycle"
showing 10 items of 378 documents
Novel performance-based technique for predicting maintenance strategy of bitumen stabilised ballast
2018
Abstract Despite being the most used worldwide, railway ballasted tracks presents high maintenance cost related to ballast settlement and particle degradation. With the aim of reducing life cycle costs, bitumen stabilised ballast (BSB) has been recently proposed as a relatively cheap alternative maintenance solution to be applied to existing tracks. This study aims at assessing the potential advantages of this technology, defining a novel maintenance strategy of traditional ballasted track-beds. A protocol for the application of the BSB technology and its associated maintenance strategy is defined. To estimate minor and major maintenance operations of BSB scenario in comparison to tradition…
Life Cycle Assessment for Supporting Eco-Design: The Case Study of Sodium–Nickel Chloride Cells
2021
The European Union is moving towards a sustainable, decarbonized, and circular economy. It has identified seven key value chains in which to intervene, with the battery and vehicle value chain being one of them. Thus, actions and strategies for the sustainability of batteries need to be developed. Since Life Cycle Assessment (LCA) is a strategic tool for evaluating environmental sustainability, this paper investigates its application to two configurations of a sodium–nickel chloride cell (planar and tubular), focusing on the active material and the anode, with the purpose of identifying the configuration characterized by the lowest environmental impacts. The results, based on a “from cradle…
Life cycle assessment of storage systems: the case study of a sodium/nickel chloride battery
2014
This study assesses the energy and environmental impacts of sodium/nickel chloride batteries, one of the emerging battery technologies for energy storage and smart grids. The analysis was conducted using the Life Cycle Assessment methodology according to the standards of the ISO 14040 series. The study system was one sodium/nickel cell battery providing electric storage for a photovoltaic system, and the manufacturing, operation, and end-of-life steps were analysed. The results indicated that the operation step has the greatest energy impact (55-70% of the total), with the manufacturing step, particularly cell manufacturing, contributing the greatest environmental impact (>60% of the total)…
An integrated energy simulation and life cycle assessment to measure the operational and embodied energy of a Mediterranean net zero energy building
2022
Abstract Net Zero Energy Buildings can play a key role in reducing the energy use, greenhouse gas emissions and the use of natural resources associated to the built environment. It is widely recognized that in low energy building a shift in relevance may occur from the operational to the embodied impacts. However, building performance assessment focus mostly on the operational phase and on primary energy consumption. This study aims to assess the energy and environmental impacts of a residential net zero energy building expanding the analysis to the full life cycle and to a wide range of environmental impact categories. The methodological approach integrates a non-steady state building ener…
An Information Systems Design Product Theory for Software Project Estimation and Measurement Systems
2009
There is relatively little research on software Project Estimation and Measurement Systems (PEMS). Commercial PEMS vary in functionality and effective- ness. Their intended users thus do not know what to ex- pect from PEMS and how to evaluate them. This paper creates an information system design product theory for the class of PEMS that prescribes the meta-requirements, the meta-design, and applicable theories for all products within the class. Meta-requirements and the meta-design are derived from the project estimation and measurement literature, experiences obtained during more than ten years of empirical work in Finnish Software Measurement Association, and a commercially available PEMS.
Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in Drosophila melanogaster.
2020
Prevention of desiccation is a constant challenge for terrestrial organisms. Land insects have an extracellular coat, the cuticle, that plays a major role in protection against exaggerated water loss. Here, we report that the ABC transporter Oskyddad (Osy)—a human ABCA12 paralog—contributes to the waterproof barrier function of the cuticle in the fruit fly Drosophila melanogaster. We show that the reduction or elimination of Osy function provokes rapid desiccation. Osy is also involved in defining the inward barrier against xenobiotics penetration. Consistently, the amounts of cuticular hydrocarbons that are involved in cuticle impermeability decrease markedly when Osy activity is reduced. …
Novel cell culture systems for the hepatitis C virus.
2001
Infections with the hepatitis C virus (HCV) are a major cause of acute and chronic liver disease. The high prevalence of the virus, the insidious course of the disease and the poor prognosis for long-term persistent infection make this pathogen a serious medical and socioeconomical problem. The identification of the viral genome approximately 10 years ago rapidly led to the delineation of the genomic organization and the structural and biochemical characterization of several virus proteins. However, studies of the viral life cycle as well as the development of antiviral drugs have been difficult because of the lack of a robust and reliable cell culture system. Numerous attempts have been un…
A Bimolecular Multicelular complementation system for the detection of syncytium formation: A new methodology for the identification of entry inhibit…
2019
AbstractFusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so called viral fusion proteins. There are multiple assays to analyze the viral entry including those that focus on the cell-cell fusion induced by some viral proteins. These methods often rely on the identification of multinucleated cells (syncytium) as a result of cell membrane fusions. In this manuscript, we describe a novel methodology for the study of cell-cell fusion. Our approach, named Bimolecular Multicelular Complementation (BiMuC), provides an adjustable platform to investigate quali…
Spatio-temporal pattern of cells expressing the clock genes period and timeless and the lineages of period expressing neurons in the embryonic CNS of…
2010
The initial steps towards the generation of cell diversity in the central nervous system of the fruitfly Drosophila melanogaster take place during early phases of embryonic development when a stereotypic population of neural progenitor cells (neuroblasts and midline precursors) is formed in a precise spatial and temporal pattern, and subsequently expresses a particular sequence of genes. The clarification of the positional, temporal and molecular features of the individual progenitor cells in the nerve cord and brain as well as of their specific types of neuronal and/or glial progeny cells forms an essential basis to understand the mechanisms controlling their development. The present study…
An integrated approach based on Life Cycle Assessment and Thermoeconomics: Application to a water-cooled chiller for an air conditioning plant
2018
Abstract A large number of methods for energy systems analysis were developed in the last decades, aimed at acquiring an in-depth understanding of plant performances and enabling analysts to identify optimal design and operating conditions. In this work an integrated approach based on Life Cycle Assessment and Thermoeconomics is proposed as a method for assessing the exergo-environmental profile of energy systems. The procedure combines the capabilities of these two techniques, to account simultaneously for aspects related to thermodynamics of energy conversion processes and to the overall impacts along the plant life cycle related to other phases, i.e. from raw material extraction to the d…