Search results for "Ligo"

Azbestu saturošu atkritumu apsaimniekošana Latvijā, problēmas un iespējamie risinājumi: Brocēnu novada piemērs

2018

Lai gan kopš 2005. gada azbestu saturošus izstrādājumus Eiropas Savienībā ir aizliegts tirgot un izmantot to kaitīguma dēļ, tie vēl joprojām ir sastopami Latvijas iedzīvotāju mājokļos – siltumizolācijas materiālos, jumta segumos un pat bremžu klučos. Latvijā nav publicētu darbu par azbesta atkritumu apsaimniekošanu, tāpēc bakalaura darbā tika izzināts potenciālais azbestu saturošo atkritumu daudzums (8220 tonnas) Brocēnu novadā, noskaidrotas novadā dzīvojošo respondentu zināšanas par azbesta kaitīgumu, informētība par to, kā jārīkojas ar azbestu saturošiem atkritumiem, un alternatīvas, kā iedzīvotāji šo atkritumu veidu mēdz apsaimniekot. Iegūtie rezultāti tika analizēti attiecībā pret inter…

Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

2021

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds of genes. However, mis-splicing does not satisfactorily explain muscle atrophy and wasting, and several other contributing factors have been suggested, including hyperactivated autophagy leading to excessive catabolism. MicroRNA ( miR ) -7 has been demonstrated to be necessary and sufficient to repress the autophagy pathway in cell models of the disease, but the origin of its low levels in DM1 was…

Nanoliposomas de baicalina y berberina en el tratamiento de afecciones cutáneas

2020

Las enfermedades cutáneas afectan a un gran número de personas. Entre ellas destacan la psoriasis, una enfermedad crónica inflamatoria, y el vitíligo, caracterizada por la despigmentación gradual de la piel. Asimismo, la alopecia representa una de las patologías con mayor impacto sobre la calidad de vida de los pacientes. Las tres tienen en común la ausencia de un tratamiento eficaz. Una de las posibles estrategias terapéuticas que pueden contribuir a resolver este problema sería la administración por vía tópica, ya que presenta una serie de ventajas frente a otras vías. En la presente Tesis Doctoral se propone la administración por vía tópica de productos naturales como coadyuvantes en el …

Search for intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network

2019

Gravitational wave astronomy has been firmly established with the detection of gravitational waves from the merger of ten stellar mass binary black holes and a neutron star binary. This paper reports on the all-sky search for gravitational waves from intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network. The search uses three independent algorithms: two based on matched filtering of the data with waveform templates of gravitational wave signals from compact binaries, and a third, model-independent algorithm that employs no signal model for the incoming signal. No intermediate mass black hole binary event was detected in this sear…

All-sky search in early O3 LIGO data for continuous gravitational-wave signals from unknown neutron stars in binary systems

2021

Rapidly spinning neutron stars are promising sources of continuous gravitational waves. Detecting such a signal would allow probing of the physical properties of matter under extreme conditions. A significant fraction of the known pulsar population belongs to binary systems. Searching for unknown neutron stars in binary systems requires specialized algorithms to address unknown orbital frequency modulations. We present a search for continuous gravitational waves emitted by neutron stars in binary systems in early data from the third observing run of the Advanced LIGO and Advanced Virgo detectors using the semicoherent, GPU-accelerated, binaryskyhough pipeline. The search analyzes the most s…

Evolution of Cell Adhesion Systems: Evidence for Arg-Gly-Asp-Mediated Adhesion in the Protozoan Neoparamoeba aestuarina

1995

Developmental processes in multicellular organisms require structural elements, such as adhesion molecules, to stabilize cells at functional positions. In vertebrates, a series of extracellular matrix proteins, e.g. fibronectin and laminin, are involved in cell adhesion. These proteins contain Arg-Gly-Asp [RGD] at their binding sites. Here we show that at concentrations above 2 mM the peptide GRGDSPK, comprising the tripeptide RGD (Arg-Gly-Asp), prevents the adhesiveness of cells of the marine amoeba Neoparamoeba aestuarina. In addition, elevated levels of GRGDSPK cause cells to alter their shapes from those with digitiform subpseudopodia to rounded cells with small lobed pseudopodia. These…

Distribution of aquatic Oligochaeta in the Finnish Lake District

1980

SUMMARY. The distribution of oligochaetes was examined at sampling stations grouped into three types: (1), in eutrophic and dystrophic areas or in areas polluted by pulp-mill wastewaters; (2), slightly eutrophic stations; (3), ‘clean’ stations unaffected by sewage or other inputs. Limnodrilus hoffmeisteri and Potamothrix hammoniensis were practically the only species in group 1, and the same species accounted for two thirds of the total numbers in group 2, although Peloscolex ferox and some other species also occurred. At the cleanest stations the dominating species were P. ferox, Psammoryctides barbatus, Stylodrilus heringianus and Tubifex tubifex. A factor analysis showed that L. hoffmeis…

Induction of (2′−5′)oligoadenylate synthetase in the marine spongesSuberites domunculaandGeodia cydoniumby the bacterial endotoxin lipopolysaccharide

2002

Recent studies have shown that the Porifera, with the examples of the demosponges Suberites domuncula and Geodia cydonium, comprise a series of pathways found also in the immune system of Deuterostomia, such as vertebrates, but are absent in Protostomia, with insects or nematodes as examples. One pathway is the (2'-5')oligoadenylate synthetase [(2-5)A synthetase] system. In the present study we show that crude extracts from tissue of S. domuncula collected from the sea display a considerable amount of (2-5)A synthetase activity; 16% of the ATP substrate is converted to the (2-5)A product, while tissue from specimens which were kept for 6 months in an aquarium shows only 1% of conversion. As…

Self-assembly of monodisperse oligonucleotide-elastin block copolymers into stars and compound micelles.

2010

Pollination of four sympatric species ofAngelonia (Scrophulariaceae) by oil-collecting bees in NE. Brazil

1991

The manner whereby the oil-producing bisaccate flowers ofAngelonia (Scrophulariaceae) are pollinated by female oil-collecting bees is reported for the first time. Observations were made in the Caatinga formation of Pernambuco, NE. Brazil, on four synchronopatric species. These differ in sizes and structural details of the corolla, level of flower exposition, and habitat preferences. All legitimate visitors wereCentris spp. (Anthophoridae):Angelonia hirta was mainly pollinated byC. fuscata andA. pubescens byC. hyptidis; A. bisaccata andA. hookeriana shared an unidentified species. Several exomalopsine, tetrapediine and meliponid bees exploit the flowers less descriminately for oil or pollen,…