Search results for "Linear Models"
showing 10 items of 440 documents
Grey matter damage and overall cognitive impairment in primary progressive multiple sclerosis
2011
Objectives: To identify associations between cognitive impairment and imaging measures in a cross-sectional study of patients with primary progressive multiple sclerosis (PPMS). Methods: Neuropsychological tests were administered to 27 patients with PPMS and 31 controls. Patients underwent brain conventional magnetic resonance imaging (MRI) sequences, volumetric scans and magnetization transfer (MT) imaging; MT ratio (MTR) parameters, grey matter (GM) and normal-appearing white matter (NAWM) volumes, and WM T2 lesion load (T2LL) were obtained. In patients, multiple linear regression models identified the imaging measure associated with the abnormal cognitive tests independently from the ot…
Age-related satisfaction with complete dentures, desire for improvement and attitudes to implant treatment
1994
In the edentulous lower jaw implant stabilised dentures have proved clinically so successful that the indication for this treatment is now being discussed more often with geriatric patients. The aim of this study of edentate subjects was to determine the age-relation of the demand for denture improvement, the risks and feasibility of implant treatment. Sixty four complete denture wearers aged from 42 to 84 years took part in the study. A questionnaire was used to determine the subjective demand for denture improvement. For 33 subjects implants seemed possible. For these patients fear and scepticism concerning implant treatment were specified and quantified. Impaired general health was the m…
The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male inf…
2008
Objective: One byproduct resulting from free radical damage is the DNA hydroxylation also known as DNA oxidation. Our aim with this work was to determine the relevance of sperm DNA oxidation on embryo quality in oocyte donation cycles. Design: We prospectively studied pairs of oocyte donation cycles, i.e., the same oocyte donors, donating to two recipients, where the only difference between the two treatments was the use of a different sperm sample. Setting: University-affiliated private IVF setting. Patient(s): Infertile male partners from couples undergoing oocyte donation cycles (n=38): 76 semen aliquots analyzed before and after semen processing by swim up. Intervention(s): None. Main O…
Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study
2015
Background Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychotic patients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls. Methods We analyzed anatomic T-1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and contr…
TESTING THE EFFECT OF THE EPIDEMIOLOGIC PARADOX: BIRTH WEIGHT OF NEWBORNS OF IMMIGRANT AND NON-IMMIGRANT MOTHERS IN THE REGION OF VALENCIA, SPAIN
2013
SummaryThe epidemiological paradox and ‘healthy migrant effect’ refer to the favourable health outcomes in unprivileged groups under unfavourable socioeconomic conditions. Weight at birth is associated with the epidemiological paradox. However, differences in fertility structure (mainly mother's age and first maternity) might be the cause of the difference in weight at birth between children of immigrant and non-immigrant mothers. This paper aims to analyse the impact of the epidemiologic paradox by distinguishing between the factors related to fertility structure, in addition to other socio-cultural factors. The importance of fertility structure as the cause of weight-at-birth differences …
Impaired Cardiopulmonary Exercise Capacity in Patients With Hyperthyroidism
1996
Hyperthyroidism (H) has been implicated as a primary cause of decreased exercise tolerance. To our knowledge, analysis of respiratory gas exchange, an efficient noninvasive method in evaluating cardiopulmonary capacity, has not been performed in patients with H.Using cardiopulmonary exercise testing, 12 consecutive women with Graves' H were examined and controlled in euthyroidism (E). Eighteen women with E, in whom cardiac catheterization had ruled out heart disease, served as control subjects (C).The ventilatory anaerobic threshold was determined by means of the V-slope method. Ergometry was performed with patients in a semisupine position using a continuous ramp protocol of 20 W/min. Echo…
Blue-yellow deficiencies in young moderate smokers.
2021
Purpose To evaluate whether tobacco affects color vision in young moderate smokers. Methods Chromatic mechanisms of 13 moderate smokers (10–20 cigarettes/day and at least 5 years smoking) and 17 non-smokers in the 18–35 age range were assessed with the Farnsworth-Munsell 100-hue (FM100h) test and short wavelength automated perimetry (SWAP). Results FM100h Total Error Scores (TES) were higher for smokers, and although differences were not significant (p = 0.14), a linear model with principal component analysis was able to explain 95% of the variance in TES and red-green partial error scores, though not in blue-yellow partial error scores (p = 0.07), using the number of years as smokers and t…
Neural Network for Estimating Energy Expenditure in Paraplegics from Heart Rate
2014
The aim of the present study is to obtain models for estimating energy expenditure based on the heart rates of people with spinal cord injury without requiring individual calibration. A cohort of 20 persons with spinal cord injury performed a routine of 10 activities while their breath-by-breath oxygen consumption and heart rates were monitored. The minute-by-minute oxygen consumption collected from minute 4 to minute 7 was used as the dependent variable. A total of 7 features extracted from the heart rate signals were used as independent variables. 2 mathematical models were used to estimate the oxygen consumption using the heart rate: a multiple linear model and artificial neural networks…
Social factors associated with nitrogen dioxide (NO2) exposure during pregnancy: The INMA-Valencia project in Spain
2011
Numerous studies have focused on the effects of exposure to air pollution on health: however, certain subsets of the population tend to be more exposed to such pollutants depending on their social or demographic characteristics. In addition, exposure to toxicants during pregnancy may play a deleterious role in fetal development as fetuses are especially vulnerable to external insults. The present study was carried out within the framework of the INMA (Infancia y Medio Ambiente or Childhood and the Environment) multicenter cohort study with the objective of identifying the social, demographic, and lifestyle factors associated with nitrogen dioxide (NO2) exposure in the subjects in the cohort…
A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder
2012
Abstract Background β-Adrenoceptor agonists are effective in animal models of bladder dysfunction, and the human bladder primarily expresses the β3 receptor subtype. Objective To evaluate the efficacy and tolerability of the highly selective and potent β3-adrenoceptor agonist solabegron in a clinical proof-of-concept study in incontinent women with overactive bladder (OAB). Design, setting, and participants This was a randomized, double-blind trial in adult women with OAB (one or more 24-h incontinence episodes and eight or more average 24-h micturitions). Interventions Solabegron 50mg ( n =88), solabegron 125mg ( n =85), or placebo ( n =85)—all twice daily—were administered. Outcome measur…