Search results for "Link"

Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration

2015

Pantethine, a natural low-molecular-weight thiol, shows broad activity in a large range of essential cellular pathways. It has been long known as a hypolipidemic and hypocholesterolemic agent. We showed recently that it exerts a neuroprotective action in mouse models of cerebral malaria and Parkinson's disease through multiple mechanisms. In the present study we looked at its effects on membrane lipid rafts that serve as platforms for molecules engaged in cell activity, therefore providing a target against inappropriate cell response leading to chronic inflammation. We found that pantethine-treated cells showed a significant change in raft fatty acid composition and cholesterol content, wit…

2021

The CMS4 mesenchymal subtype of colorectal cancer (CRC) is associated with poor prognosis and resistance to treatment. The cellular prion protein PrPC is overexpressed in CMS4 tumors and controls the expression of a panel of CMS4-specific genes in CRC cell lines. Here, we sought to investigate PrPC downstream pathways that may underlie its role in CMS4 CRC. By combining gene set enrichment analyses and gain and loss of function approaches in CRC cell lines, we identify the integrin-linked kinase ILK as a proximal effector of PrPC that mediates its control on the CMS4 phenotype. We further leveraged three independent large CRC cohorts to assess correlations in gene expression pattern with pa…

2019

Mammalian fetuin-A and fetuin-B are abundant serum proteins with pleiotropic functions. Fetuin-B is a highly selective and potent inhibitor of metallopeptidases (MPs) of the astacin family, which includes ovastacin in mammals. By inhibiting ovastacin, fetuin-B is essential for female fertility. The crystal structure of fetuin-B was determined unbound and in complex with archetypal astacin, and it was found that the inhibitor has tandem cystatin-type modules (CY1 and CY2). They are connected by an exposed linker with a rigid, disulfide-linked `CPDCP-trunk', and are followed by a C-terminal region (CTR) with little regular secondary structure. The CPDCP-trunk and a hairpin of CY2 form a bipar…

Using a hazard-independent approach to understand road-network robustness to multiple disruption scenarios

2021

Abstract A range of predictable and unpredictable events can cause road perturbations, disrupting traffic flows and more generally the functioning of society. To manage this threat, stakeholders need to understand the potential impact of a multitude of predictable and unpredictable events. The present paper adopts a hazard-independent approach to assess the robustness (ability to maintain functionality despite disturbances) of the Sioux Falls network to all possible disruptions. This approach allows understanding the impact of a wide range of disruptive events, including random, localised, and targeted link failures. The paper also investigates the predictability of the link combinations wh…

Signaling Reduction in 5G eV2X Communications Based on Vehicle Grouping

2019

Groups of users, sometimes referred to as clusters, have been exploited in several works to enhance wireless communications. Leveraging on previous ideas, the main goal of this paper is to take advantage of vehicle grouping in order to reduce uplink signaling in fifth generation (5G) vehicular communications. Several schemes to reduce uplink signaling are proposed and particularized in two specific 5G uses cases: the reporting of Channel Busy Ratio (CBR), and the reporting of beam measurements in beam management procedures. The achieved signaling reduction is analytically evaluated in an example of urban scenario with high vehicle densities for different group sizes. The signaling load can …

Varieties of State Aid and Technological Development: Government Support to the Pulp and Paper Industry, the 1970s to the 1990s

2018

Countries promote the development of pulp and paper industry through industrial, technology and innovation policy measures. Direct interventions and regional and environmental policies, together with more general governmental measures on trade negotiations, taxation, labour policies, and infrastructure development (e.g. roads, energy) have also had an impact on shaping the geographical location of and investments in the pulp and paper industry. This chapter presents an historical overview of government support on pulp and paper industry in the Organisation for Economic Co-operation and Development (OECD) countries from roughly the 1970s to the 1990s. As the earlier literature suggests, in c…

Word derivational knowledge and writing proficiency: How do they link?

2016

Abstract Although word derivational (WD) knowledge, i.e., how new words are formed from existing words with help of derivational affixes, is considered important for learners of second or foreign languages (L2), there is still no clear answer as to what aspects comprise the construct of L2 English word derivational knowledge and how it develops. The present study adds to our knowledge on how the ability to derive English words develops among L2 English learners. More specifically, it sheds light on how word derivational knowledge relates to communicatively defined Common European Framework of Reference (CEFR) language proficiency levels regarding learners' writing skills. In the study, 117 …

1,2,3-Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3-Dipolar Cycloadditions

2014

1,3-Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of heterocyclic rings, with applications in different fields. In this review we focus on the synthesis of biologically active compounds possessing the 1,2,3-triazole core through 1,3-dipolar cycloaddition reactions. The 1,2,3-triazole skeleton can be present as a single disubstituted ring, as a linker between two molecules, or embedded in a polyheterocycle. The cycloaddition reactions are usually catalysed by copper or ruthenium. Domino reactions can be achieved through dipolarophile anion formation, generally followed by cyclisation. The variety of attainable heterocyclic structures gives an ill…

Kaukana Kainuussa, valtaväylän varrella : etnologinen tutkimus Kontiomäen rautatieläisyhteisön elinkaaresta 1950-1972

2004

FL Kimmo Lagerblomin etnologian väitöskirjan ”Kaukana Kainuussa, valtaväylän varrella. Etnologinen elinkaaritutkimus Kontiomäen rautatieläisyhteisöstä vuosina 1950-1973.” tarkastustilaisuus. Vastaväittäjänä professori Pekka Leimu (Turun yliopisto) ja kustoksena professori Bo Lönnqvist.Kimmo Lagerblomin tutkimus on ensimmäinen Suomessa tehty väitöskirja, jonka painopiste on rautatieläiskulttuurissa. Kontiomäen lisäksi tutkimuksessa tarkastellaan laajemminkin rautatien historiallista merkitystä sekä Suomessa että muualla. This study is located on Kontiomäki railtown; witch is a small village some 600 kilometres north from Helsinki. Kontiomäki is a typical railtown. The Finnish State Railway C…

Synchronizing the release rates of salicylate and indomethacin from degradable chitosan hydrogel and its optimization by definitive screening design.

2018

Abstract Three types of ionically crosslinked (with citric acid) chitosan discs were loaded with the highly water- soluble drug, sodium salicylate (SS) and the poorly water-soluble drug, indomethacin (Ind). In separate experiments the hydrated discs were immersed in a de-crosslinking solution comprising of different concentrations of calcium chloride, which induced a controlled erosion of the discs, a process which was optimized to synchronize the release rates of the two drugs over a predetermined period of time. The optimization was accomplished by manipulating six factors: chitosan MW, its amount in the formulation, the concentration of the crosslinker agent, the concentration of the de-…