Search results for "Lip"

Production and optimization of exocellular lipases produced by Proteus mirabilis

2016

Lipazy są wytwarzane przez rośliny, zwierzęta i mikroorganizmy, ale tylko te pochodzenia mikrobiologicznego są ważne dla przemysłu ze względu na zróżnicowane właściwości enzymatyczne i specyficzność substratową. Mimo że enzymy te są syntetyzowane przez wiele gatunków mikroorganizmów, to nadal poszukuje się nowych, środowiskowych szczepów zdolnych do syntezy zewnątrzkomórkowych lipaz. Celem przeprowadzonych badań była ocena aktywności lipolitycznej Proteus mirabilis w zależności od pH oraz temperatury. Aktywność lipolityczną analizowano w zakresie pH 4-9 oraz w temperaturach 5-60ºC. Do oznaczenia aktywności lipolitycznej posłużono się metodą miareczkową, a wyniki podano jako ilość uwolnionyc…

A novel putative interactor for the low density lipoprotein receptor cytoplasmic domain

2011

Familial hypercholesterolemia (FH) is a genetic disease mainly caused by mutations in the low density lipoprotein receptor (LDLLDLLDL-R) gene. However, FH-like phenotypes may also arise from mutations occurring in other genes, the products of which normally interact with the LDLLDLLDL receptor. Although several FH-associated proteins have been discovered, many FH-like phenotypes cannot be linked to mutations in already characterized genes, suggesting the existence of other genes still to be identified, the mutations of which may be directly linked to the FH disorder. In order to identify new putative LDLLDLLDLr interactors possibly involved in its internalization and/or sorting, the cytopla…

Variazioni delle sottofrazioni delle lipoproteine ricche in trigliceridi durante la dialisi in soggetti uremici

2001

Accumulation of remnant-like particles in normolipidemic men with premature coronary artery disease

2003

The Role of Fructose as a Cardiovascular Risk Factor: An Update

2022

There is increasing presence of fructose in food and drinks, and some evidence suggests that its higher consumption increases cardiovascular risk, although the mechanisms still remain not fully elucidated. Cardiovascular diseases (CVD) are still responsible for one-third of deaths worldwide, and therefore, their prevention should be assessed and managed comprehensively and not by the evaluation of individual risk factor components. Lifestyle risk factors for CVD include low degree of physical activity, high body mass index, alcohol consumption, smoking, and nutritional factors. Indeed, nutritional risk factors for CVD include unhealthy dietary behaviors, such as high intake of refined foods…

Should we routinely measure low-density and high-density lipoprotein subclasses?

2009

Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) plasma populations are composed of heterogeneous subfractions that are different in size, density and protein/lipid content. There is increasing evidence that small, dense LDL particles are strongly associated with higher cardiovascular disease risk. Similarly, several studies have investigated whether smaller HDL particles are more protective than their larger counterparts and more recent findings suggest that small, dense HDL has significantly higher atheroprotective activity than larger L HDL. Yet, certain impairments of the protein/lipid content in small, dense HDL may decrease its antiatherogenic capacity or even induce p…

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

2013

Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in t…

Lipo-Sarcoma Multifocale del Funicolo Spermatico: indicazioni al trattamento chirurgico e descrizione di un caso con follow-up a lungo termine.

2006

Poster per X Riunione S.R.S.-S.I.A.. Messina (Milazzo), 28-29 Aprile 2006

Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications

2019

In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in gene therapy has had a great impact in the medical field, holding enormous promise, becoming “the latest generation medicine” with the first ever siRNA-lipid based formulation approved by the United States Food and Drug Administration (FDA) for human use, and currently on the market under the trade name Onpattro™. The growth of such powerful biologic therapeutics has gone hand in hand with the progress in delivery systems technology, which is absolutely required to improve their safety and effectiveness. Lipid carrier systems, particularly liposomes, have been proven to be the most su…

Glycerosomes:investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances

2017

Glycerosomes were formulated using 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC), diclofenac sodium salt and 10, 20 or 30% glycerol in the water phase, while corresponding liposomes were prepared with the same amount of DMPC and diclofenac, without glycerol. The aim of the present work was to evaluate the effect of the used phospholipid on vesicle features and ability to favour diclofenac skin deposition by comparing these results with those found in previous works performed using hydrogenated soy phosphatidylcholine (P90H) and dipalmitoylphosphatidylcholine (DPPC). Liposomes and glycerosomes were multilamellar, liposomes being smaller (72±6nm). Interactions among glycerol, phospho…