Search results for "Lip"
showing 10 items of 8306 documents
Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis
2012
Monoclonal B Lymphocytosis (MBL) is defined as asymptomatic monoclonal B-cell expansion characterised by a CLL-phenotype, but with less than 5 x 10(9)/I circulating cells. Reactive oxygen species (ROS)-mediated cell damage plays a critical role in the initiation of carcinogenesis as well as in malignant transformation. The goal of this study was to perform an analysis of the oxidative stress statuses of patients affected by MBL and chronic lymphocytic leukaemia (CLL). We examined peripheral blood and urine specimens from 29 patients with MBL, 55 with CLL and 31 healthy subjects. There was a significant increase in the occurrence of the mutagenic base 8-oxo-2'-deoxiguanosine (8-oxo-dG) in th…
9-cis-Retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene
1997
The role of retinoic acids (RA) on liver fatty acid- binding protein (L-FABP) expression was investigated in the well differentiated FAO rat hepatoma cell line. 9-cis-Retinoic acid (9-ci's-RA) specifically enhanced L-FABP mRNA levels in a time- and dose-dependent manner. The higher induction was found 6 h after addition of 10 -6 M 9-CK-RA in the medium. RA also enhanced further both L-FABP mRNA levels and cytosolic L-FABP protein content induced by oleic acid. The retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR), which are known to be activated, respectively, by 9-c/s-RA and long chain fatty acid (LCFA), co-operated to bind specifically the peroxisome prol…
A subset of flavaglines inhibits KRAS nanoclustering and activation.
2020
The RAS oncogenes are frequently mutated in human cancers and among the three isoforms (KRAS, HRAS and NRAS), KRAS is the most frequently mutated oncogene. Here, we demonstrate that a subset of flavaglines, a class of natural anti-tumour drugs and chemical ligands of prohibitins, inhibit RAS GTP loading and oncogene activation in cells at nanomolar concentrations. Treatment with rocaglamide, the first discovered flavagline, inhibited the nanoclustering of KRAS, but not HRAS and NRAS, at specific phospholipid-enriched plasma membrane domains. We further demonstrate that plasma membrane-associated prohibitins directly interact with KRAS, phosphatidylserine and phosphatidic acid, and these int…
1986. Las elecciones generales de 22 de junio de 1986. "El cuarto año triunfal para Felipe González"
2014
El 12 de marzo de 1986 se celebraba el Referéndum OTAN. Semanas después Felipe González adelantaba las elecciones generales al 22 de junio de 1986, cinco meses antes de los cuatro años del fin de la legislatura. Contaba con dos bazas importantes a nivel internacional. La primera era que España había firmado el Acta de Adhesión de España a las Comunidades Europeas -hoy Unión Europea- el 12 de junio de 1985, ingresando el 1 de enero de 1986. Dos meses después, el 12 de marzo de 1986 convocó el referéndum sobre la permanencia de España en la OTAN, en el que el Sí que defendía el Gobierno socialista ganó con un 52,5% de votos a favor y un 39,85% de votos en contra. Tras el éxito del referéndum,…
Advanced Systems for Skin Delivery of Cyanocobalamin: A Model Molecule for > 1 kDa Drugs
2022
La optimización de la biodisponibilidad de los fármacos brinda una segunda oportunidad a los fármacos que, por diversas razones, no pueden ejercer un efecto terapéutico óptimo. La piel se ha utilizado como plataforma para administrar medicamentos desde la antigüedad y, en la actualidad, se sigue considerando como una de las principales alternativas a la vía oral. Sin embargo, como interfaz entre el organismo y el medio ambiente externo, la capa más externa de la piel (estrato córneo) impide la entrada de sustancias. Esta oposición es de gran importancia para las moléculas de gran tamaño, considerando 500 Da como el tamaño máximo para que una molécula difunda de forma natural a través de la …
Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and…
2006
Background— Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association. Methods and Results— We investigated the interaction between APOA5 gene variation and dietary fat in determining plasma fasting TGs, remnant-like particle (RLP) concentrations, and lipoprotein particle size in 1001 men and 1147 women who were Framingham Heart Study participants. Polymorphisms –1131T>C and 56C>G, representing 2 independent haplotypes, were analyzed. Significant gene–diet interactions between the –1131T>C polymorphism and polyunsaturated fatty acid (PUFA) intake were found (PG polymorphism. The –1131…
Video Viewing Patterns Using Different Teaching Treatments: A Case Study Using YouTube Analytics
2019
Aquest estudi explora els patrons de visualització de 17 vídeos en un context tradicional daprenentatge i en un context de classe invertida per 723 estudiants de negocis cursant un mòdul relacionat amb . Mentre recerques anteriors s?han centrat principalment en resultats (per exemple, satisfacció/resultats dels alumnes), en aquest estudi l?enfocament recau en com la natura de les interaccions del estudiants amb el vídeos por determinar-se mitjançant un anàlisi profund de les dades analítiques. Els nostres resultats mostren menys interacció amb els vídeos en el context de la classe invertida que en el de la classe tradicional. De la mateixa manera, mostren un ús més elevat dels vídeos com a …
Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies
2020
Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA an…
Gestión del agua subterránea de uso agrícola: Los retos de la sostenibilidad socio-ambiental y la equidad
2018
Sicilia, el "impuesto del millon" y el fin de la tregua de los doce años (1618-1621)
2015
The last years of the reign of Philip III and the beginning of that of Philip IV were characterized by an expansion of the fronts of conflict: from the Mediterranean, to the north- ern part of the Italian peninsula, the heart of Europe. The military engagement, especially on imperial territory and Flanders (since 1621), demanded an increase in the tax burden in all domains of the Monarchy. In Sicily, to encounter the demands of “socorros” from Madrid, it became necessary to revise and streamline the entire administrative apparatus / tax and iden- tify new taxations forms. This study aims to offer a reflection on the measures taken between 1618 and 1621 in order to rearrange the writing acco…