Search results for "Lip"

Mikä muuttui 20 vuoden aikana? : Pohdintaa ikääntyvän puoliso-omaishoitajan asemasta ja kotiin saatavasta tuesta

2022

publishedVersion Non peer reviewed

Sosiaali- ja terveydenhuollon ammattilaisetkaan eivät aina huomaa lähisuhdeväkivaltaa, ja siksi sen havaitsemiseen pitää panostaa

2022

Lähisuhteissa eli muun muassa pari- ja perhesuhteissa tapahtuva väkivalta on Suomessa hyvin yleistä. Noin joka kymmenes suomalainen eli noin 340 000 henkilöä elää parhaillaan väkivaltaisessa parisuhteessa ja lapsuudessaan lähisuhdeväkivaltaa on kokenut jopa 70 % aikuisväestöstä eli yli kaksi miljoonaa henkilöä. Lähisuhdeväkivalta voi olla henkistä, fyysistä tai seksuaalista. nonPeerReviewed

He kept us out of war? : yleisen mielipiteen vaikutus Woodrow Wilsonin päätöksiin Yhdysvaltain liittymisestä ensimmäiseen maailmansotaan

2003

Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics

2012

In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally analyzed by the occurrences of spikes and bursts both in time and space. Commonly accepted analysis tools employ burst detection algorithms based on predefined criteria. However, maturing neuronal networks, such as those originating from human embryonic stem cells (hESCs), exhibit highly variable network structure and time-varying dynamics. To explore the developing burst/spike activities of such networks, we propose a burst detection algorithm which utilizes the firing …

Språkpolicy vid svenskspråkiga daghem i Finland: tvåspråkiga barns handlingar och agens

2016

The aim of this article is to examine communicative actions of nine Swedish-Finnish bilingual children enrolled in Swedish-medium early childhood education and care in Finland. We discuss the interplay between declared monolingual language policy, and the ideology of supporting the language background of the bilingual child. As a result we found a dual practiced language policy. With the agency and actions of bilingual children we could identify both monolingual policy being practiced, but also a bilingual policy being constructed at the same time. Neither of the practiced dual policies seemed to be explicitly resisted either by the children or the pedagogical practitioners. The communicati…

Kohti yhteistä laatua : henkilökunnan, vanhempien ja lasten laatukäsitykset päiväkodin integroidussa erityisryhmässä

2000

Topics in calculus and geometry on metric spaces

2022

In this thesis we present an overview of some important known facts related to topology, geometry and calculus on metric spaces. We discuss the well known problem of the existence of a lipschitz equivalent metric to a given quasiultrametric, revisiting known results and counterexamples and providing some new theorems, in an unified approach. Also, in the general setting of a quasi-metric doubling space, suitable partition of unity lemmas allows us to obtain, in step two Carnot groups, the well known Whitney’s extension theorem for a given real function of class C^m defined on a closed subset of the whole space: this result relies on relevant properties of the symmetrized Taylor’s polynomial…

RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations

2020

Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustments include increased expression and phosphorylation of ATG2B as well as augmented formation of the ATG12-ATG5 conjugate. Moreover, ATG9A shows an enhanced phosphorylation at amino acid residues tyrosi…

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

2011

Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…

Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.

2005

Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…