Search results for "Lip"
showing 10 items of 8306 documents
Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia.
2021
Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid management experts gathered to discuss several open questions on BA characteristics and BArelated practical clinical issues. The panel permitted collection of its opinions in a ten Q&A format. Aim: The aim of this viewpoint is to discuss and answer several open questions on BA characteristics and BA-r…
Fosfolipīdu cietfāzes ekstrakcijas kolonnu izmantošana antibiotiku noteikšanā ar augsti efektīvā šķidruma hromatogrāfiju – tandēma maasspektrometriju
2015
Darbā tika izstrādāta paraugu sagatavošanas metodeantibiotiku atlieku noteikšanai dzīvnieku izcelsmes produktos, izmantojot fosfolipīdu atdalīšanas cietfāzes ekstrakcijas kolonnas. Efektīvai atlieku detektēšanai ar augsti efektīvo šķidruma hromatogrāfiju – tandēma masspektrometriju eksperimentālitika noteiktas katrai vielai raksturīgāsskenēšanas pārejas un to sadursmju enerģijas, optimizēti jonizācijas avota parametri, piemeklēta kustīgā fāze un hromatogrāfijas kolonna ar vislielāko selektivitāti un efektivitāti. Izstrādātās metodes piemērotība antibiotiku atlieku noteikšanai tika pārbaudīta validācijas gaitā.Izstrādātā metode tika pielietota antibiotiku atlieku noteikšanai piena, gaļas, ni…
Effectiveness and safety of lomitapide in a patient with familial chylomicronemia syndrome
2020
Background: Familial chylomicronemia syndrome (FCS) is characterized by severe fasting hypertriglyceridemia, abdominal pain, and recurrent acute pancreatitis. Available triglyceride-lowering drugs are insufficient to avoid pancreatitis. Therefore, there is a significant unmet medical need for effective triglyceride-lowering drugs for patients with FCS. Case report: We report the second case of a patient with FCS and recurrent pancreatitis treated with lomitapide. Lomitapide treatment resulted in a reduction of fasting TG levels from 2897 mg/dL (32.71 mmol/L) to an average of 954 mg/dL (10.77 mmol/L) on the 30 mg lomitapide equating to a 67% reduction from baseline. After 26 months of lomita…
Indefinite integrals involving the incomplete elliptic integrals of the first and second kinds
2016
ABSTRACTA substantial number of indefinite integrals are presented for the incomplete elliptic integrals of the first and second kinds. The number of new results presented is about three times the total number to be found in the current literature. These integrals were obtained with a Lagrangian method based on the differential equations which these functions obey. All results have been checked numerically with Mathematica. Similar results for the incomplete elliptic integral of the third kind will be presented separately.
Indefinite integrals involving the incomplete elliptic integral of the third kind
2016
ABSTRACTA substantial number of new indefinite integrals involving the incomplete elliptic integral of the third kind are presented, together with a few integrals for the other two kinds of incomplete elliptic integral. These have been derived using a Lagrangian method which is based on the differential equations which these functions satisfy. Techniques for obtaining new integrals are discussed, together with transformations of the governing differential equations. Integrals involving products combining elliptic integrals of different kinds are also presented.
Automorphisms of hyperelliptic GAG-codes
2009
Abstract We determine the n –automorphism group of generalized algebraic-geometry codes associated with rational, elliptic and hyperelliptic function fields. Such group is, up to isomorphism, a subgroup of the automorphism group of the underlying function field.
Analysis of emerging and related pollutants in aquatic biota
2020
Water bodies cover approximately 70 % of the earth s surface, making them ecosystems with a high environmental value and the habitat for numerous species of flora and fauna. Emerging pollutants (EPs) are ubiquitous anthropogenic compounds of environmental concern that can be found at different concentration levels in matrices such as sediment, water and aquatic biota. In addition, EPs can be bioaccumulated and biomagnified, inducing adverse effects on biota, and posing a risk to humans when contaminated biota is consumed. Unlike abiotic matrices, the occurrence of EPs in aquatic biota has not been widely studied. This is probably because their complexity, due to the presence of lipids, prot…
Polypyrrole films functionalized with pendant titanocene dichloride complexes: Ellipsometric study of the electropolymerization process
2007
Electrochemical and ellipsometric methods have been used to study the electropolymerization process of a functionalized monomer, Tc3Py (in which pyrrole is covalently bonded with titanocene dichloride complex) on platinum electrode from a dilute monomer solution in acetonitrile. The deposition has been performed in the potentiodynamic regime. A new method for the acquisition and treatment of ellipsometric data has been proposed which allowed us to analyze the evolution of the film properties at each potential. The model of a single uniform layer was unable to describe the ellipsometric experimental observations with the necessary precision. A proper fitting of the data has been achieved con…
Micellar liquid chromatography for prediction of drug transport.
2000
Abstract The vast majority of well absorbed drugs are transported passively across the cell membranes. Physicochemical descriptors of drug molecules that are believed to influence transcellular transport are routinely used to predict drug absorption by means of complex mathematical models. In this paper, a new in vitro method, based on the retention data in micellar liquid chromatography (MLC), is validated for the prediction of passive drug absorption. The retention of a heterogeneous drugs set in MLC using Brij 35 as surfactant in the mobile phase is compared with the retention data reported in literature obtained in red cell membrane lipid liposomes, human red cell membranes vesicles (ve…
Digestion and absorption rates of [3H]-oleic acid and [14C]-triolein do not differ in rats fed heated (-) and (+) gossypol cottonseed and soybean flo…
1998
This study was conducted to compare in vivo the acute effects of heated (+) and (-) gossypol cottonseed flours with those of soybean flour on lipid digestion and absorption in growing rats. Rats were fed by gastric intubation mixed [ 3 H]-oleic acid and [ 14 C]-triolein with heated flours or without flour (control). Lipid digestion and absorption were determined for 6 h after meal intubation. Both radioactivities recovered in gastrointestinal tract were significantly higher in rats fed (+) gossypol cottonseed flour than in all other groups. The majority of both recovered radioactivities was found in stomach contents, then in stomach wall and finally in intestinal wall. The distribution of b…