Search results for "Lipide"
showing 10 items of 532 documents
Therapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2)
2011
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a calcium-independent phospholipase A2 that circulates in plasma in association with lipoprotein particles, whereas in atherosclerotic plaques it is co-localized with macrophages. Lp-PLA2 generates two proinflammatory mediators, lysophosphatidylcholine and oxidized nonesterified fatty acids, which play a role in the development of atherosclerotic lesions and formation of a necrotic core, leading to more vulnerable plaques. Epidemiologic studies demonstrate that increased circulating levels of Lp-PLA2 predict an increased risk of myocardial infarction, stroke and cardiovascular mortality. Furthermore, histologic examination of diseased hum…
La diabetes mellitus y el riesgo cardiovascular. ¿Es necesario el tratamiento integral de la diabetes mellitus tipo 2 y los factores de riesgo cardio…
2010
ResumenLas enfermedades cardiovasculares (CV) son la primera causa de muerte en la población española, tanto en personas diabéticas como no diabéticas. En la diabetes, la enfermedad CV es entre 2 y 4 veces más frecuente, más precoz y más agresiva. Con las medidas actuales se puede llegar a una prevención del ∼50% de la enfermedad CV. Los factores de riesgo CV en la diabetes son la hipertensión arterial (HTA), la dislipemia, el tabaquismo, la obesidad y el sedentarismo. Más del 80% de pacientes con diabetes tipo 2 presenta HTA y dislipemia, y aproximadamente un 15% sigue fumando. Pero menos de un 10% tiene todos estos factores controlados. Aunque la dislipemia es el factor más condicionante …
Participation des facteurs nutritionnels et environnementaux au vieillissement de la rétine et aux rétinopathies liées à l’âge
2012
Aging is defined by all the physiological processes that alter the structure and functions of the body. With advanced age, aging of the human retina can evolve into pathological forms, agerelated macular degeneration (AMD) or diabetic retinopathy (DR). The mechanisms involved in the transition from normal aging to a pathologic state are poorly understood. Oxidative stress and advanced glycation end-products are promoting factors for aging of the retina. Meanwhile, epidemiological studies suggest that a diet rich in long-chain omega-3 polyunsaturated fatty acids (LC-PUFA) such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), potentially protects against the development of AMD a…
Tratamiento hipolipemiante en los pacientes con enfermedad cardiovascular de riesgo muy elevado. Documento de consenso SEC sobre las indicaciones de …
2021
Different primary and secondary prevention studies have documented that a greater degree of reduction in low-density lipoprotein cholesterol (LDL-C) levels is associated with a greater decrease in cardiovascular event rates. PCSK9 inhibitors achieve important, rapid and sustained decreases in LDL-C. New clinical practice guidelines for the management of dyslipidemia establish reduced target levels of LDL-C. These goals are hardly achievable with a statin-only treatment, even in combination with ezetimibe. The addition of PCSK9 inhibitors can play a determining role in achieving these recommendations. However, it is important to identify the patient subgroups that can most benefit from this …
Use of Combination Statin and Bile Acid Sequestrant Therapy to Treat Dyslipidemia
2015
Lipid management guidelines promulgated around the world continue to emphasize the need to reduce serum levels of low-density lipoprotein cholesterol (LDL-C) in order to reduce risk for acute cardiovascular events in both the primary and secondary prevention settings [1–3]. There is growing consensus that when it comes to LDL-C management, lower is better with no apparent lower limit that is discernible from current evidence, i.e., there is greater and greater benefit as LDL-C decreases with no apparent loss in safety [4–8]. Dyslipidemia and coronary artery disease (CAD) are widely prevalent throughout the world. Considerable effort continues to be focused on expanding the appropriate use o…
Le Dislipidemie Genetiche. Il Progetto LIPIGEN
2011
Le Dislipidemie genetiche rappresentano un gruppo di patologie dell’Adulto e pediatriche che interessano nel nostro paese un numero considerevole di individui. Alcune di esse come le Ipercolesterolemie determinano un elevatissimo rischio cardiovascolare. Altre si associano a presentazioni cliniche polimorfe, specie in età pediatrica. Una proporzione rilevante di pazienti non viene diagnosticato e per la stragrande maggioranza di soggetti affetti da una di queste forme la diagnosi genetico-molecolare non è sempre disponibile. Allo scopo di risolvere tali criticità, la SISA si è fatta promotore del progetto LIPIGEN, un network strutturato per la gestione clinica e di laboratorio delle Dislipi…
IL PROGETTO LIPIGEN: UN AGGIORNAMENTO
2012
NEXT GENERATION SEQUENCIN: A NEW METHODOLOGICAL APPROACH FOR THE MOLECULAR DIAGNOSIS OF GENETIC DYSLIPIDEMIAS
2014
La dislipidemia nei lavoratori a turni
2011
Perceptions of justice influencing community acceptance of spent nuclear fuel disposal : A case study in two Finnish nuclear communities
2019
Final disposal of spent nuclear fuel (SNF) from nuclear power plants (NPPs) is an ethical issue with implications within and across generations. We address this issue from the perspective of nuclear communities that host nuclear waste disposal sites. These are primarily the communities that face injustice due to the potential radiological risks. A resident survey (n = 454) was conducted in two Finnish nuclear communities, i.e. Eurajoki and Pyhäjoki, that are being considered as alternative sites for a second repository for SNF. The nuclear waste management (NWM) company Posiva is already building a repository in Eurajoki, the first in Finland. These communities are in different stages of th…