Search results for "Lipoplex"
showing 3 items of 3 documents
A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for potent melanoma immunothera…
2017
A shared tumor-antigen RNA-lipoplex vaccine with/without anti-PD1 in patients with checkpoint-inhibition experienced melanoma.
2020
3136 Background: Cancer vaccines are considered unsuitable for patients with advanced tumours and have not been clinically successful. Methods: Lipo-MERIT is an ongoing phase 1/2 trial (NCT02410733) with melanoma FixVac, a liposomal RNA vaccine targeting four non-mutant shared tumour-associated antigens (TAAs) (MAGE-A3, NY-ESO-1, tyrosinase, TPTE). Patients with stage IIIB-C and IV melanoma are eligible. The trial comprises 7 dose escalation and 3 dose expansion cohorts, the latter with FixVac alone or combined with anti-PD1. Eight doses of FixVac are administered i.v. weekly/bi-weekly followed by optional continued monthly treatment. This abstract summarizes the findings of an exploratory…
Desarrollo de competencias profesionales en biomedicina utilizando el aprendizaje basado en proyectos
2019
[EN] Professional competences in the field of experimental sciences are acquired through the practice of professional practice. In the university environment, the knowledge, skills and abilities in the different undergraduate subjects are taught in a parceled manner. Our 45 students biotechnology studies in Catholic University of Valencia, during the internship repeat protolocos and follow a recipe to perform an experiment that exemplifies the fundamental contents of the subject being taught. The aboradaje of this work is based on project-based learning. The student has to elaborate a biotechnological project from beginning to end. The project is based on the construction of a non-viral vec…